Hormone Therapy and Estrogen Therapy

“If you do not have a uterus,
you can take estrogen alone,
without a progestogen”.1

Umbrella
What may the Hormone Therapy and Estrogen Therapy Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Estrogen Alone
  • Estrogen Therapy (ET)
  • Estrogen-Alone HRT/MHT
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Oestrogen-Only HRT
  • Oestrogen-Only Therapy/Oestrogen Only Therapy
  • Systemic ET

No UterusHormone Therapy and Estrogen Therapy

Who may choose to use estrogen therapy (ET)?

On page two in Deciding About Hormone Therapy Use: Estrogen Alone or Estrogen Plus Progestogen, published July 2022, the North American Menopause Society (NAMS) note:

“If you do not have a uterus, you can take estrogen alone, without a progestogen”.2

On page one in HRT: Which HRT? Oestrogen Alone, published November 2021, the (British) Women’s Health Concern elaborate on:

“The core ingredient of all forms of HRT is oestrogen. Oestrogen relieves hot flushes and the other menopausal symptoms and maintains bone strength. This is suitable for women who have had a total hysterectomy, where the whole womb including its neck (cervix) has been removed. Oestrogen alone can be taken as a daily tablet, a weekly or twice weekly patch, a daily gel or an implant. Varying doses of oestrogen are available”.3

Formulations and Options

What are some ET formulations and options?

In The 2023 Practitioner’s Toolkit for Managing Menopause: Management – MHT Formulations and Options: Estrogen Therapy, published online 30 October 2023, the authors elaborate on:

“Estrogen can be used systemically as oral conjugated equine estrogen, estradiol valerate, estrone sulfate or micronized estradiol; transdermal estradiol (patches, gels, spray); a vaginal estradiol ring; and implanted estradiol pellets (mostly not regulator-approved). Vaginal pessaries and creams are used to treat urogenital symptoms”.4

Venous Thromboembolic Disease

What is the association between venous thromboembolic disease (VTE) and ET?

In The 2023 Practitioner’s Toolkit for Managing Menopause: Management – Considerations for All Women At Menopause: Menopausal Hormone Therapy the authors include:

  • “Oral estrogen is associated with an increased risk of venous thromboembolic disease (VTE), although the absolute risk is small for women aged <60 years. The risk is lower/not at all with transdermal estradiol, which is preferred for women at increased risk of VTE (i.e. smokers, obese women and diabetic women)”.5

Health Care Provider

If I choose to use ET what are my risks?

Different women who choose to use ET can have different risks. It may therefore be in your best interest to choose to talk to your health care provider about this.

If I choose to use estrogen plus progestogen (EPT) what are my risks?

Different women who choose to use EPT can have different risks. It may therefore be in your best interest to also choose to talk to your health care provider about this.

On page two in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause first published online 10 June 2022, one of the recommendations is:

  • “The decision whether to take HRT, the dose and duration of its use should be made on an individualised basis after discussing the benefits and risks with each patient. This should be considered in the context of the overall benefits obtained from using HRT including symptom control and improving quality of life as well as considering the bone and cardiovascular benefits associated with HRT use”.6

On page one in Deciding About Hormone Therapy Use: Estrogen Alone or Estrogen Plus Progestogen, the NAM explain:

“Every woman is different, and you will decide about whether to use HT based on the severity of your symptoms, your personal and family health history, and your own beliefs about menopause treatments. Your healthcare professional will be able to help you with your decision”.7

Health Topics A-Z

Where may I find Health Topics A-Z related to Hormone Therapy and Estrogen Therapy?

In Health Topics A-Z on you may find:

Health Topics A-Z

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New or Updated

  1. 8 Myths and Truths About Menopausal Hot Flashes
  2. Askearlymenopause.org [Ask EM] [+ Video: What Is Early Menopause?]
  3. BMS & WHC’s 2020 Recommendations on Hormone Replacement Therapy In Menopausal Women
  4. BMS TV: Bioidentical Hormones
  5. BMS TV: Coronary Heart Disease (CHD)
  6. BMS TV: HRT and Bleeding
  7. BMS TV: HRT and Breast Cancer: Overall Risks and Benefits
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  10. Bioidentical Hormone Therapy
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  12. Compounded Bioidentical Hormone Therapy [Video]
  13. Deciding About Hormone Therapy Use
  14. Dr Louise Newson: The Truth About the Menopause & HRT
  15. Endometrial Safety of Low-Dose Vaginal Estrogens
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  17. Estrogen Dependent Cancers
  18. Estrogen Therapy and Breast Cancer In Randomized Clinical Trials: A Narrative Review
  19. Estrogen: What It Does and 5 Benefits
  20. FAQs: Hormone Therapy for Menopause
  21. Guidance on Menopausal Hormone Therapy [Video]
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  24. HRT – Types, Doses and Regimens
  25. HRT: Benefits and Risks
  26. Hormone Replacement Therapy
  27. Hormone Replacement Therapy (HRT)
  28. Hormone Replacement Therapy (HRT): Benefits and Risks of Hormone Replacement Therapy (HRT)
  29. Hormone Replacement Therapy (HRT): Oestrogen Tablets, Patches, Gel and Spray
  30. Hormone Replacement Therapy (HRT): Side Effects of Hormone Replacement Therapy (HRT)
  31. Hormone Replacement Therapy (HRT): Types of Hormone Replacement Therapy (HRT)
  32. Hormone Replacement Therapy (HRT): Vaginal Oestrogen: About Vaginal Oestrogen
  33. Hormone Replacement Therapy (HRT): Vaginal Oestrogen: Common Questions About Vaginal Oestrogen
  34. Hormone Replacement Therapy (HRT): Vaginal Oestrogen: Side Effects of Vaginal Estrogen
  35. Hormone Therapy: Four Things A Mayo Clinic Women’s Health Specialist Wants You To Know [+ Video]
  36. Hormone Therapy: Is It Right for You?
  37. Hot Flashes
  38. Hot Flashes
  39. How To Find Relief for Hot Flashes At Night
  40. Hot Flashes: What Can I Do? [+ Video]
  41. I Forgot To Ask the Doctor – E9: The Menopause: Can Every Woman That Wants It Have HRT?
  42. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause
  43. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – Hormone Replacement Therapy (HRT) [+ Video: Is HRT Bad for You?] [Other Languages and Formats]
  44. Management of Perimenopausal and Menopausal Symptoms
  45. Mayo Clinic Minute: Help With Hot Flashes Due To Menopause [+ Video Courtesy: Mayo Clinic News Network]
  46. Mayo Clinic Minute: Lifestyle Changes To Manage Menopause Symptoms [+ Video]
  47. Menopausal Hormone Therapy
  48. Menopausal Hormone Therapy and Breast Cancer Risk
  49. Menopausal Hormone Therapy and Venous Thromboembolism
  50. Menopausal Hormone Therapy and Women’s Health: An Umbrella Review
  51. Menopausal Hormone Therapy, Heart Disease and Stroke
  52. Menopause
  53. Menopause
  54. Menopause
  55. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  56. Menopause Hormone Therapy: Does It Cause Vaginal Bleeding?
  57. Menopause Management Options: Menopausal Hormone Therapy (MHT)
  58. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Medication Tracker
    Hormone Therapy and Estrogen Therapy
  59. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
  60. Menopause Patient Information [Videos] 2. Talking To Your GP About Menopause
  61. Menopause Patient Information [Videos] 3. The Risks & Benefits of HRT
  62. Menopause Patient Information [Videos] 4. The Different Types of HRT
  63. Menopause Preparedness Toolkit Video Series: Treating Vasomotor Symptoms of Menopause
  64. Menopause Preparedness Toolkit: A Woman’s Empowerment Guide
  65. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  66. Menopause Treatments: What Works, What Doesn’t
  67. Menopause and HRT
  68. Menopause, Perimenopause, Hormone Therapy and Other Treatments With Madelyn Butler, MD [Podcast]
  69. Menopause: Diagnosis & Treatment
  70. Mymenoplan.org [My Menoplan, United States]
  71. Navigating Menopause: Expert Insights and Solutions | Dr Susan Davis | The Proof Podcast EP 245
  72. Navigating Menopause: Honest Answers To All Your Questions [+ Video: What To Expect in Menopause]
  73. Nonhormone Treatments for Hot Flashes and Night Sweats
  74. Oestrogen Tablets, Patches, Gel and Spray
  75. Randomized Trials of Estrogen-Alone and Breast Cancer Incidence: A Meta-Analysis
  76. Risks and Benefits of MHT
  77. The 2023 Practitioner’s Toolkit for Managing Menopause
  78. The Truth About Menopause Supplements | Dr Sarah Berry
  79. Therapy for the Effects of Menopause
  80. Tips To Help Manage Menopause Symptoms
  81. Types of Hormone Therapy
  82. Vaginal Dryness
  83. Vaginal Oestrogen
  84. Video Series-2022: Hormone Therapy: Understanding the Risks and Benefits
  85. Video Series-2022: Perimenopause, Signs, Symptoms, and Solutions
  86. Video Series-2023: NAMS 2023 Nonhormone Therapies Position Statement for Bothersome Menopause Symptoms
  87. Video Series-2023: New FDA-Approved Nonhormone Option for the Treatment of Hot Flashes
  88. Video Series-2024: Preparing for Your Menopause Health Care Visit
  89. Video: Leslie Cho, MD, Discusses CV Risks, Benefits of Menopausal Hormone Therapy
  90. Videos and Podcasts: Videos – Interviews: A Simple Approach To Menopause: The Menopause Quick Six (www.MQ6.ca)
  91. Videos and Podcasts: Videos – Interviews: The Women’s Health Initiative – What Can We Believe?
  92. Webinars: Previous – Non-Pharmacological Interventions For VMS
  93. Webinars: Previous – Perimenopausal Contraception [21 May 2024]
  94. What Are the Benefits and Risks of HRT?
  95. What Does Estrogen Do?
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  97. Why Didn’t Anyone Tell Me This? Episode 3: Dr Annice Mukherjee: Your Essential Menopause Toolkit

Sources

Where may I find the Sources quoted above?

You may find the Sources at:

Sources

  1. Deciding About Hormone Therapy Use: Estrogen Alone or Estrogen Plus Progestogen. 2022:2. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 31 March 2024
  2. Deciding About Hormone Therapy Use: Estrogen Alone or Estrogen Plus Progestogen. 2022:2. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 31 March 2024
  3. HRT: Which HRT? Oestrogen Alone. November 2021: 1. Women’s Health Concern https://www.womens-health-concern.org/wp-content/uploads/2022/12/09-WHC-FACTSHEET-HRT-NOV2022-B.pdf Accessed: 31 March 2024
  4. Davis, S. R., Taylor, S., Hemachandra, C., Magraith, K., Ebeling, P. R., Jane, F., and Islam, R. M. The 2023 Practitioner’s Toolkit for Managing Menopause: Management – MHT Formulations and Options: Estrogen Therapy. Published Online: 30 October 2023 https://www.tandfonline.com/doi/full/10.1080/13697137.2023.2258783 Accessed: 31 March 2024
  5. Davis, S. R., Taylor, S., Hemachandra, C., Magraith, K., Ebeling, P. R., Jane, F., and Islam, R. M. The 2023 Practitioner’s Toolkit for Managing Menopause: Management – Considerations for All Women At Menopause: Menopausal Hormone Therapy. Published Online: 30 October 2023 https://www.tandfonline.com/doi/full/10.1080/13697137.2023.2258783 Accessed: 31 March 2024
  6. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 10 June 2022:3-4. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 31 March 2024
  7. Deciding About Hormone Therapy Use: Estrogen Alone or Estrogen Plus Progestogen. 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 31 March 2024
Topic Last Updated: 01 June 2024 – Topic Last Reviewed: 31 March 2024

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