Hormone Therapy Risks

“The risks of HT differ for different women, depending on type, dose, duration of use, route of administration, timing of initiation, and whether a progestogen is needed”.1

Umbrella
What may the Hormone Therapy Risks Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT) Risks
  • Hormone Therapy (HT) Risks
  • Menopausal Hormone Therapy (MHT) Risks

Date

What can it be important to be clear about with hormone therapy (HT) risks information?

I think it can be important to be clear about the date of all information including the date of HT risks information, because this information may have been updated.

Symptoms or Chronic Conditions

What can it also be important to be clear about with HT risks information?

I think it can also be important to be clear about whether HT risks information is about the use of HT for the management of menopausal symptoms such as hot flushes, night sweats and vaginal dryness or for the prevention of chronic conditions such as cardiovascular disease, cancer and osteoporosis.

Estrogen Plus Progestogen and Estrogen Therapy

Can the risks of HT differ for Estrogen Plus Progestogen (EPT) and Estrogen Therapy (ET)?

Yes.

Uterus or No UterusHormone Therapy Risks

Can the risks of differ for women who have a uterus and women who do not a uterus?

Yes.

Different Differences

What are some other HT risks differences?

On page one in the NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use the North American Menopause Society (NAMS) elaborate on:

  • “The risks of HT differ for different women, depending on type, dose, duration of use, route of administration, timing of initiation, and whether a progestogen is needed. Treatment should be individualized using the best available evidence to maximize benefits and minimize risks, with periodic reevaluation for the benefits and risks of HT continuation”.2

Risk and Benefits

Are HT risks small and usually outweighed by the benefits?

In Hormone Replacement Therapy (HRT): Risks the (United Kingdom) NHS (National Health Service) note:

“Many studies on HRT that have been published over the past 15 years highlight the potential risks. As a result, some women and doctors have been reluctant to use HRT.

But more recent evidence says that the risks of HRT are small and are usually outweighed by the benefits”.3

NICE Guidelines

What did the (British) National Institute for Health and Care Excellence’s (NICE) guidelines note about the benefits and risks of hormone replacement therapy (HRT)?

In Menopause: Diagnosis and Management – Information for the Public: Benefits and Risks of HRT the NICE explain and elaborate on:

“NICE looked at the risks of the following conditions in women taking HRT compared with women of menopausal age in the general population. Your GP should explain that the risks of the conditions described below vary from one woman to another and depend on many risk factors. In cases where HRT is said to increase risk this usually means a very small increase in most women.

  • Blood Clots (Venous Thromboembolism)…
  • Heart Disease and Stroke (Cardiovascular Disease)…
  • Breast Cancer…
  • Type 2 Diabetes…
  • Osteoporosis…
  • Loss of Muscle Strength…
  • Dementia…”.4

Revised Global Consensus Statement

What is one of the points of consensus about menopausal hormone therapy (MHT) and risk?

One of the points of consensus in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section A: Benefit/Risk Profile of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “MHT, including tibolone and the combination of conjugated equine estrogens and bazedoxifene (CE/BZA), is the most effective treatment for vasomotor symptoms (VMS) associated with menopause at any age, but benefits are more likely to outweigh risks if initiated for symptomatic women before the age of 60 years or within 10 years after menopause”.5


What are vasomotor symptoms?

The International Menopause Society explain:

“Hot flushes and night sweats are also referred to as Vasomotor Symptoms (VMS)”.6

Before Age 60

Before age 60, can age and time since menopause matter?

On page one in the NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use the NAMS note:

  • “For women aged younger than 60 years or who are within 10 years of menopause onset and have no contraindications, the benefit-risk ratio appears favorable for treatment of bothersome hot flashes and for those at elevated risk of bone loss or fracture. Longer duration may be more favorable for estrogen-alone therapy than for estrogen-progestogen therapy, based on the Women’s Health Initiative randomized, controlled trials”.7

On page one in Deciding About Hormone Therapy Use: Potential Risks published in June 2017, the NAMS also explain:

“As with all medications, HT is associated with some potential risks. For healthy women aged younger than 60 years with bothersome hot flashes who are within 10 years of menopause, the benefits of HT generally outweigh the risks. Hormone therapy might slightly increase your risk of stroke or blood clots in the legs or lungs (especially if taken in pill form)”.8

After Age 60

After age 60, can age and time since menopause matter?

On page one in the NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use the NAMS note:

Hormone Therapy Risks

  • “For women who initiate HT more than 10 or 20 years from menopause onset or when aged 60 years or older, the benefit -risk ratio appears less favorable than for younger women because of greater absolute risks of coronary heart disease, stroke, venous thromboembolism, and dementia”.9

On page one in Deciding About Hormone Therapy Use: Potential Risks the NAMS also explain:

“If started in women aged older than 65 years, HT might increase the risk of dementia. If you have a uterus and take estrogen with progestogen, there is no increased risk of cancer of the uterus. Hormone therapy (combined estrogen and progestogen) might slightly increase your risk of breast cancer if used for more than 4 to 5 years. Using estrogen alone (for women without a uterus) does not increase breast cancer risk at 7 years but may increase risk if used for a longer time”.10

At Risk

What are some contraindications to taking HT?

In Menopause Management: Menopausal Hormone Therapy (MHT) – Contraindications To Taking MHT the (Australian) Jean Hailes for Women’s Health (JH) elaborate on these and more contraindications:

  • “Current, past or suspected breast cancer
  • Known or suspected oestrogen-dependent cancer, such as breast and uterine cancers
  • Undiagnosed vaginal bleeding
  • Untreated uterine lining thickening, which could develop into cancer
  • Current thrombosis or DVT (deep vein thrombosis), but a past history would require further investigation to establish if MHT is safe
  • Thrombophilia (a group of conditions that lead to an increased risk of thrombosis)…”.11

Do Not Take

Which women should not take HT?

In Menopause: Medicines To Help You the (United States) Food and Drug Administration elaborate on:

“Do not take hormone therapy if you:

  • Have problems with vaginal bleeding
  • Have or have had certain cancers such as breast cancer or uterine cancer
  • Have or have had a blood clot, stroke or heart attack
  • Have a bleeding disorder
  • Have liver disease
  • Have allergic reactions to hormone medicine”.12

Health Care Provider

If I choose to take HT, how may I find out what my risks are?

If you choose to take HT, it may be in your best interest to also choose to ask your health care provider about this.

One of the points of consensus in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT is:

Hormone Therapy Risks

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.13

What is VTE?

VTE can be an abbreviation for Venous Thromboembolism.

In Hormone Replacement Therapy (HRT): Risks the NHS elaborate on:

“When deciding whether to have hormone replacement therapy (HRT), it’s important to understand the risks.

It’s also important to consider HRT as only 1 of a range of options to improve menopausal and postmenopausal health and wellbeing”.14

On page one in Deciding About Hormone Use the NAMS explain:

“Every woman is different—and you must make a decision about whether to use HT based on the severity of your symptoms, your personal and family health history, and your own beliefs about menopause treatments. Your healthcare provider will be able to help you with your decision”.15

In Menopause Management: Menopausal Hormone Therapy (MHT) – Should You Take MHT? the JH include:

  • “Jean Hailes recommends each woman discusses her decision about taking MHT with her doctor regularly and whenever there are any concerns”.16

In Menopause: Diagnosis & Treatment – Treatment: Hormone Therapy the (United States) Mayo Clinic note:

“Before deciding on any form of treatment, talk with your doctor about your options and the risks and benefits involved with each. Review your options yearly, as your needs and treatment options may change”.17

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy Risks?

In Health Topics A-Z may find:

Health Topics A-Z

Links

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Links

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  1. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT)
  2. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 6. Myth – Complementary Medicines and Therapies Are As Effective As MHT and Safer
  3. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 7. Myth – Compounded Bioidentical Hormone Therapy Is Safer Than Conventional MHT
  4. A Fresh Perspective on A Recurring Challenge Benefit-Risk Discussion Intnerational Menopause Society Webinar
  5. BMS, IMS, EMAS, RCOG and AMS Joint Statement on Menopausal Hormone Therapy and Breast Cancer Risk In Response To EMA Pharmacovigilance Risk Assessment Committee Recommendations In May 2020 [17 January 2021]
  6. Bioidentical Hormone Therapy
  7. Bioidentical Hormones Explained – A British Menopause Society Video
  8. Bioidentical Hormones: Are They Safer?
  9. Combined Menopausal Hormone Therapy (MHT)
  10. Complementary Medicine Options for Menopausal Symptoms
  11. Complementary and Alternative Therapies Explained – A British Menopause Society Video
  12. Compounded Bioidentical Hormone Therapy [Video]
  13. Deciding About Hormone Therapy
  14. Deciding About Hormone Therapy Use
  15. Decidir Sobre La Hormonoterapia
  16. Early Menopause: Experiences and Perspectives of Women and Health Practitioners – Women’s Profiles
  17. Estrogen & Hormones
  18. Estrogen & Hormones: Postmenopausal Hormone Replacement Therapy
  19. Family History
  20. HRT
  21. HRT Benefits and Risks
  22. HRT and Breast Cancer: Overall Risks and Benefits Explained – A British Menopause Society Video
  23. HRT and the Risk of Breast Cancer Explained – A British Menopause Society Video
  24. HRT: Summary
  25. HRT: The History
  26. Hormone Replacement Therapy
  27. Hormone Replacement Therapy (HRT)
  28. Hormone Replacement Therapy (HRT) Explained – A British Menopause Society Video
  29. Hormone Replacement Therapy (HRT): Overview – Risks and Side Effects of HRT
  30. Hormone Replacement Therapy (HRT): Overview – Who Can Take HRT
  31. Hormone Replacement Therapy (HRT): Risks
  32. Hormone Replacement Therapy (HRT): Types
  33. Hormone Replacement Therapy Safe, Despite Rare Blood Clot Risks From Tablets
  34. Hormone Therapy: Is It Right for You?
  35. Index To Drug-Specific Information [United States]
  36. Information About Menopause [Multiply Languages] [Videos]
  37. MHT and Breast Cancer Risk
  38. Making Choices At Menopause
  39. Making Sense of Menopausal Hormone Therapy Means Understanding the Benefits As Well As the Risks
  40. Menopause
  41. Menopause
  42. Menopause
  43. Menopause
  44. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  45. Menopause Hormone Therapy and Your Heart
  46. Menopause Hormone Therapy and Your Heart: How To Limit the Risks
  47. Menopause Hormone Therapy: Does It Cause Vaginal Bleeding?
  48. Menopause Hormone Therapy: Follow-Up Appointments?
  49. Menopause Hormone Therapy: Who Shouldn’t Take It?
  50. Menopause Management: Menopausal Hormone Therapy (MHT) – Benefits & Risks of HRT
  51. Menopause Management: Menopausal Hormone Therapy (MHT) – What Are the Risks of HRT?
  52. Menopause Matters
  53. Menopause Symptoms and Relief
  54. Menopause Treatment
  55. Menopause – Is Menopausal Hormone Therapy (HRT) Safe? [Multiply Languages] [Video]
  56. Menopause: Diagnosis & Treatment
  57. Menopause: Diagnosis and Management – Information for the Public: Benefits and Risks of HRT [NICE Guideline]
  58. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  59. Menopause: Medicines To Help You
  60. Menopause: Menopause – Hormone Treatments
  61. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use
  62. National Center for Complementary and Integrative Health: How Safe Is This Product or Practice?
  63. National Center for Complementary and Integrative Health: Know the Science: How Medications and Supplements Can Interact
  64. National Center for Complementary and Integrative Health: Menopausal Symptoms In Depth
  65. Oestrogen Only Menopausal Hormone Therapy
  66. Practical Prescribing Explained – A British Menopause Society Video
  67. Recent Review Confirms Safety of Low Dose Vaginal Estrogen: July 2019
  68. Resequedad Vaginal
  69. Revised Global Consensus Statement on Menopausal Hormone Therapy
  70. Risks and Benefits of MHT/HRT
  71. Sex and Menopause: Treatment for Symptoms
  72. The North American Menopause Society Statement on Continuing Use of Systemic Hormone Therapy After Age 65
  73. Tipos de Hormonoterapia
  74. Types of Hormone Therapy
  75. Understanding Health Risks: Improve Your Chances for Good Health
  76. Urogenital Atrophy Explained – A British Menopause Society Video
  77. Urogenital Problems
  78. Vaginal Dryness
  79. Vaginal Dryness
  80. Vaginal Dryness Alternative Treatments
  81. Venous Thrombosis/Thromboembolism Risk and Menopausal Treatments
  82. Video Series-2018 – Tailoring Estrogen Therapy for Maximum Cardiovascular Health
  83. Video Series-2019 – What Is New In Hormone Therapy?
  84. Video Series-2020 – TSECs—A New Treatment for Hot Flashes and Night Sweats
  85. Video Series-2020 – What You Need To Know About Bioidentical Hormone Therapy
  86. Video Series-2021 – What Women Need To Know About Hormone Therapies
  87. What Is MHT and Is It Safe? Vietnamese: What Is Menopausal Hormone Therapy (MHT) and Is It Safe?
  88. What Is Menopausal Hormone Therapy (MHT) and Is It Safe?
  89. Women Can Breathe Sigh of Relief When Using Vaginal Estrogen To Treat Menopause Symptoms

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use. 20 June 2017:1. North American Menopause Society https://www.menopause.org/docs/default-source/default-document-library/ht-press-release-061917.pdf Accessed: 18 January 2021
  2. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use. 20 June 2017:1. North American Menopause Society https://www.menopause.org/docs/default-source/default-document-library/ht-press-release-061917.pdf Accessed: 18 January 2021
  3. Hormone Replacement Therapy (HRT): Risks. Page Last Reviewed: 09 September 2019. NHS (National Health Service) https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/risks/ Accessed: 18 January 2021
  4. Menopause: Diagnosis and Management – Information for the Public: Benefits and Risks of HRT. Published Date: 12 November 2015. Last Updated: 05 December 2020. National Institute for Health and Care Excellence https://www.nice.org.uk/guidance/ng23/ifp/chapter/Benefits-and-risks-of-HRT Accessed: 18 January 2021
  5. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section A: Benefit/Risk Profile of MHT. Climacteric, 2016;19:4:313 https://www.imsociety.org/manage/images/pdf/ba6379e868044bec13015ac2b84f2753.pdf Accessed: 18 January 2021
  6. Hot Flushes and Night Sweats – Background Information: What Are Hot Flushes and Night Sweats? October 2011:1. International Menopause Society https://www.imsociety.org/downloads/world_menopause_day_2011/wmd_media_backgrounder.pdf Accessed: 18 January 2021
  7. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use. 20 June 2017:1. North American Menopause Society https://www.menopause.org/docs/default-source/default-document-library/ht-press-release-061917.pdf Accessed: 18 January 2021
  8. Deciding About Hormone Therapy Use: Potential Risks. 2017:1. North American Menopause Society https://www.menopause.org/docs/default-source/for-women/menonote-deciding-about-ht-2017.pdf Accessed: 18 January 2021
  9. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use. 20 June 2017:1. North American Menopause Society https://www.menopause.org/docs/default-source/default-document-library/ht-press-release-061917.pdf Accessed: 18 January 2021
  10. Deciding About Hormone Therapy Use: Potential Risks. 2017:1. North American Menopause Society https://www.menopause.org/docs/default-source/for-women/menonote-deciding-about-ht-2017.pdf Accessed: 18 January 2021
  11. Menopause Management: Menopausal Hormone Therapy (MHT): Contraindications To Taking MHT. Last Updated: 07 December 2020 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management/ Accessed: 18 January 2021
  12. Menopause: Medicines To Help You. Content Current As of: 22 August 2019. Food and Drug Administration https://www.fda.gov/ForConsumers/ByAudience/ForWomen/ucm118627.htm Accessed: 18 January 2021
  13. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/manage/images/pdf/ba6379e868044bec13015ac2b84f2753.pdf Accessed: 18 January 2021
  14. Hormone Replacement Therapy (HRT): Risks. Page Last Reviewed: 09 September 2019. NHS (National Health Service) https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/risks/ Accessed: 18 January 2021
  15. Deciding About Hormone Therapy Use. 2017:1. North American Menopause Society https://www.menopause.org/docs/default-source/for-women/menonote-deciding-about-ht-2017.pdf Accessed: 18 January 2021
  16. Menopause Management: Menopausal Hormone Therapy (MHT): Should You Take MHT? Last Updated: 30 July 2020 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management/ Accessed: 18 January 2021
  17. Menopause: Diagnosis & Treatment – Treatment: Hormone Therapy. 14 October 2020. Mayo Clinic https://www.mayoclinic.org/diseases-conditions/menopause/diagnosis-treatment/drc-20353401 Accessed: 18 January 2021

Topic Last Updated: 18 January 2021 – Topic Last Reviewed: 18 January 2021
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