Hormone Therapy and Estrogen Plus Progestogen Therapy

Hormone Therapy and Estrogen Plus Progestogen Therapy

“Because estrogen stimulates the lining of the uterus, women with a uterus need to take an additional hormone, progestogen, or a tissue-selective estrogen complex…”.1

Umbrella

What may the Hormone Therapy and Estrogen Plus Progestogen Therapy Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Combination Estrogen and Progestin Medicines
  • Combination HT/HRT
  • Combination Hormone Replacement/Hormone Therapy
  • Combined Hormonal Therapy
  • Combined Hormone Replacement Therapy
  • Estrogen Plus Progestogen
  • Estrogen With Progestogen Therapy
  • Estrogen and Progestin (Hormone Replacement Therapy)
  • Estrogen-Progestogen Therapy (EPT)
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Oestrogen and Progesterone Therapy

Hormone Therapy

What is hormone therapy (HT) or menopausal hormone therapy (MHT)?

In Glossary of Terms: Menopausal Hormone Therapy (MHT) Hormone Replacement Therapy (HRT)/ Hormone Therapy (HT), dated April 2026, the Australasian Menopause Society’s (AMS) definition is:

“MHT also known as hormone replacement therapy (HRT) or hormone therapy (HT) refers to hormones prescribed to help oestrogen deficiency. This is most commonly prescribed for women around the time of menopause to relieve menopausal symptoms and to prevent osteoporosis. Women with other causes of oestrogen deficiency (such as pituitary gland problems) may also be prescribed hormone therapy”.2

Progesterone

What is progesterone?

DotS the definition of progesterone may vary. The AMS’s definition is:

“Progesterone
Progesterone is the natural hormone found in a woman’s body that helps prepare the endometrium (lining of the uterus) for the fertilized egg”.3

Progestogen

What is progestogen?

DotS the definition of progestogen may vary. The AMS’s definition is:

“Progestogen
Progestogen is a hormone which can be natural or synthetic, but has a similar effect on a woman’s body as progesterone. Progestin is a synthetic hormone which has the actions of progesterone”.4

UterusHormone Therapy and Estrogen Plus Progestogen Therapy

Who can choose to use estrogen plus progestogen hormone therapy (HT)?

In Treatments for Menopause: Menopausal Hormone Therapy (MHT) – Types of MHT the (Australian) Jean Hailes for Women’s Health (JH) explain:

“If you still have a uterus, oestrogen and progesterone are used together. Progesterone reduces the risk of endometrial cancer (cancer of the uterus)”.5

On page one in Deciding About Hormone Therapy Use, published February 2025, the Menopause Society (formerly the North American Menopause Society) also note:

“Hormone therapy involves taking estrogen in doses high enough to raise the level of estrogen in your blood in order to treat hot flashes and other symptoms. Because estrogen stimulates the lining of the uterus, women with a uterus need to take an additional hormone, progestogen, or a tissue-selective estrogen complex (TSEC) to protect the uterus”.6/

Health Care Provider

What if I choose to use estrogen plus progestogen (EPT)?

In Treatments for Menopause: Menopausal Hormone Therapy (MHT) JH explain:

“When using MHT, your doctor will probably suggest you:

  • “Start low” (start with a low dose)
  • “Go slow” (take some time to let the medicine work before increasing the dose)
  • “Review often” (review your dose with your doctor once each year)”.7

Health Topics A-Z

Where may I find Health Topics A-Z related to Hormone Therapy and Estrogen Plus Progestogen Therapy?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

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New or Updated

  1. All About Progesterone | Dr Louise Newson
  2. Askearlymenopause.org [Ask EM] [+ Video: What Is Early Menopause?]
  3. BMS TV: Progestogens
  4. Bioidentical Hormones: Are They Safer?
  5. Can HRT Stop Your Periods?
  6. Consumer Video and Podcast Series: 2023 Consumer Videos and Podcasts – Lifestyle Modification and Prevention of Breast Cancer
  7. Consumer Video and Podcast Series: 2024 Consumer Videos and Podcasts – Preparing for Your Menopause Health Care Visit
  8. Deciding About Hormone Therapy
  9. Deciding About Hormone Therapy Use
  10. EMAS On-Demand Webinars [European Menopause and Andropause Society] [Multiply Languages]: Benefits of Oral Combined MHT for Estrogen Deficiency Symptoms Treatment [Multiply Languages]
  11. Find A Menopause Practitioner [United States and Other]
  12. Find A Practitioner [Australasian Menopause Society i.e. Australia and New Zealand]
  13. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  14. Finding the Right Hormone Treatments (HRT): Types, Doses and What Works
  15. Glossary of Terms
  16. HRT Questions Answered
  17. HRT – Types, Doses and Regimens
  18. HRT: How To Find the Right Dose & Type | Dr Louise Newson
  19. Handling Hot Flushes and Night Sweats| Dr Louise Newson
  20. Hormone Replacement Therapy (HRT)
  21. Hormone Replacement Therapy (HRT): Benefits and Risks
  22. Hormone Replacement Therapy (HRT): Benefits and Risks of Hormone Replacement Therapy (HRT)
  23. Hormone Replacement Therapy (HRT): Continuous Combined Hormone Replacement Therapy (HRT) Tablets, Capsules and Patches
  24. Hormone Replacement Therapy (HRT): Continuous Combined Hormone Replacement Therapy (HRT) Tablets, Capsules and Patches – Side Effects of Continuous Combined HRT
  25. Hormone Replacement Therapy (HRT): Oestrogen Tablets, Patches, Gel and Spray
  26. Hormone Replacement Therapy (HRT): Sequential Combined Hormone Replacement Therapy (HRT) Tablets and Patches
  27. Hormone Replacement Therapy (HRT): Sequential Combined Hormone Replacement Therapy (HRT) Tablets and Patches – Side Effects of Sequential Hormone Replacement Therapy (HRT)
  28. Hormone Replacement Therapy (HRT): Types of Hormone Replacement Therapy (HRT)
  29. Hormone Replacement Therapy (HRT): Utrogestan (Micronised Progesterone)
  30. Hormone Replacement Therapy (HRT): Utrogestan (Microsecond Progesterone) – Side Effects of Utrogestan
  31. Hormone Therapy: Is It Right for You?
  32. Hot Flashes
  33. Hot Flashes
  34. International Menopause Society (IMS) Recommendations and Key Messages on Women’s Midlife Health and Menopause
  35. Menopause
  36. Menopause
  37. Menopause
    Black Women’s Menopause
  38. Menopause Definitions
  39. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
  40. Menopause Map: Downloadable Resources – Stages of Menopause: Medication Tracker
    Hormone Therapy and Estrogen Plus Progestogen Therapy
  41. Menopause Symptoms and Relief
  42. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  43. Menopause Treatment
  44. Menopause What Are the Symptoms?
  45. Menopause: Diagnosis & Treatment
  46. Menopause: Identification and Management [NICE Guideline]
  47. Menopause: Identification and Management [NICE Guideline]Hormone Therapy
  48. Navigating Menopause Care Resource Guide
    Hormone Therapy
  49. Online Events [International Menopause Society]: IMS Partnership Symposia Series – What’s Hot? Options for Treatment of Hot Flushes 2025
  50. Online Events [International Menopause Society]: Past Webinars – 2026: New IMS Recommendations: Evidence-Based Management of Vasomotor Symptoms
  51. Online Events [International Menopause Society]: Past Webinars – 2026: New IMS Recommendations – Midlife Body Changes
  52. Practical HRT Tips | Dr Louise Newson
  53. Progesterone Intolerance | Dr Louise Newson
  54. Progestin Sensitivity / Progesterone Intolerance
  55. Slynd As Endometrial Protection
  56. The 2023 Practitioner’s Toolkit for Managing Menopause
  57. The Hormone Confusion That’s Affecting Millions of Women – Sara Hover
  58. Treatments for Menopause
  59. Understanding Hormone Therapy for Menopausal Symptoms
  60. Updated 2024 NICE Menopause Guidance Summary
  61. Video: Hormone Therapy Protects Bone, Heart, Brain Health During Menopause
  62. Videos & Podcasts: Videos – Menopause and Hormone Therapy: Current Perspectives and Controversies
  63. What Are the Benefits and Risks of HRT? [Videos]
  64. World Menopause Day 2024: Leaflet for Women – Menopause and Menopause Hormone Therapy [Multiply Languages]Hormone Therapy and Estrogen Plus Progestogen Therapy
  65. World Menopause Day 2024: The IMS White Paper: Menopause and MHT In 2024: Addressing the Key Controversies [Multiply Languages]

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Deciding About Hormone Therapy Use. 2025:1. Menopause Society https://menopause.org/wp-content/uploads/default-document-library/MenoNote-Deciding-About-HT-2025.pdf Accessed: 10 July 2026
  2. Glossary of Terms: Menopausal Hormone Therapy (MHT) Hormone Replacement Therapy (HRT)/ Hormone Therapy (HT). 22 April 2026. Australasian Menopause Society’s https://hub.menopause.org.au/Play?pId=b474d931-428c-4cf7-a80a-74ff4287b33d Accessed: 10 July 2026
  3. Glossary of Terms: Progesterone. 22 April 2026. Australasian Menopause Society https://hub.menopause.org.au/Play?pId=b474d931-428c-4cf7-a80a-74ff4287b33d Accessed: 10 July 2026
  4. Glossary of Terms: Progesterone. 22 April 2026. Australasian Menopause Society https://hub.menopause.org.au/Play?pId=b474d931-428c-4cf7-a80a-74ff4287b33d Accessed: 10 July 2026
  5. Treatments for Menopause: Menopausal Hormone Therapy (MHT) – Types of MHT. Jean Hailes for Women’s Health https://www.jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 10 July 2026
  6. Deciding About Hormone Therapy Use. 2025:1. Menopause Society https://menopause.org/wp-content/uploads/default-document-library/MenoNote-Deciding-About-HT-2025.pdf Accessed: 10 July 2026
  7. Treatments for Menopause: Menopausal Hormone Therapy (MHT). Jean Hailes for Women’s Health https://www.jeanhailes.org.au/health-topics/menopause/treatments-for-menopause/ Accessed: 10 July 2026
Topic Last Updated: 21 July 2026 – Topic Last Reviewed: 10 July 2026

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