“Because estrogen stimulates the lining of the uterus, women with a uterus need to take an additional hormone, progestogen, to protect the uterus”.1

Umbrella
What may the Hormone Therapy and Estrogen Plus Progestogen Therapy Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Combination Estrogen and Progestin Medicines
  • Combination HT/HRT
  • Combination Hormone Replacement/Hormone Therapy
  • Combined Hormonal Therapy
  • Combined Hormone Replacement Therapy
  • Estrogen Plus Progestogen
  • Estrogen With Progestogen Therapy
  • Estrogen and Progestin (Hormone Replacement Therapy)
  • Estrogen-Progestogen Therapy (EPT)
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Oestrogen and Progesterone Therapy

Hormone Therapy

What is hormone therapy (HT) or menopausal hormone therapy (MHT) ?

DotS the definition of HT or MHT may vary. In Menopause Management Options: Menopausal Hormone Therapy (MHT) – What Is MHT? the (Australian) Jean Hailes for Women’s Health’s definition is:

“MHT is the medical replacement of female hormones oestrogen and progesterone, and sometimes testosterone”.2

Progesterone

What is progesterone?

DotS the definition of progesterone may vary. In Glossary of Terms the Australasian Menopause Society’s (AMS) definition is:

“Progesterone is the ovarian hormone produced by the corpus luteum which prepares the endometrium for implantation of the fertilized egg”.3

Progestogen

What is progestogen?

DotS the definition of progestogen may vary. The AMS’s definition is:

“Progestogen is a hormone which can be natural or synthetic but has a similar effect on a woman’s body as progesterone”.4

Progestin

What is progestin?

DotS the definition of progestin may vary. The AMS’s definition is:

“Progestin is a synthetic hormone which has the actions of progesterone”.5

UterusHormone Therapy and Estrogen Plus Progestogen Therapy

Who can choose to use estrogen plus progestogen hormone therapy (HT)?

On page one in Deciding About Hormone Therapy Use, published July 2022, the North American Menopause Society elaborate on:

“ Hormone therapy involves taking estrogen in doses high enough to raise the level of estrogen in your blood in order to treat hot flashes and other symptoms. Because estrogen stimulates the lining of the uterus, women with a uterus need to take an additional hormone, progestogen, to protect the uterus”.6

In Menopause Management Options: Menopausal Hormone Therapy (MHT) – Types of MHT the JH explain:

“If you haven’t had a hysterectomy, oestrogen and progesterone are used together, as progesterone reduces the risk of endometrial cancer (cancer of the uterus).

Other combinations of oestrogen and progestogen (including progesterone and other progesterone-like hormones) may also be recommended”.7

Health Care Provider

If I choose to use estrogen plus progestogen (EPT) what are my risks?

Different women who choose to use EPT can have different risks. It may therefore be in your best interest to also choose to talk to your health care provider about this.

On page two in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause first published 10 June 2022, one of the recommendations is:

  • “The decision whether to take HRT, the dose and duration of its use should be made on an individualised basis after discussing the benefits and risks with each patient. This should be considered in the context of the overall benefits obtained from using HRT including symptom control and improving quality of life as well as considering the bone and cardiovascular benefits associated with HRT use”.8

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy and Estrogen Plus Progestogen Therapy?

In Health Topics A-Z you may find:

Links

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Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Deciding About Hormone Therapy Use. 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 17 September 2022
  2. Menopause Management Options: Menopausal Hormone Therapy (MHT) – What Is MHT? Last Updated: 08 September 2022 | Last Reviewed: 19 August 2022. Jean Hailes for Women’s Health https://www.jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 17 September 2022
  3. Glossary of Terms: Progesterone. Content Updated: February 2022. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/381-glossary-of-terms Accessed: 17 September 2022
  4. Glossary of Terms: Progestogen. Content Updated: February 2022. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/381-glossary-of-terms Accessed: 17 September 2022
  5. Glossary of Terms: Progestin. Content Updated: February 2022. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/381-glossary-of-terms Accessed: 17 September 2022
  6. Deciding About Hormone Therapy Use. 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 17 September 2022
  7. Menopause Management Options: Menopausal Hormone Therapy (MHT) – Types of MHT: Oestrogen and  Progesterone Therapy. Last Updated: 08 September 2022 | Last Reviewed: 19 August 2022. Jean Hailes for Women’s Health https://www.jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 17 September 2022
  8. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First published 10 June 2022:3-4. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 17 September 2022
Topic Last Updated: 17 September 2022 – Topic Last Reviewed: 17 September 2022

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