“Women who still have a uterus need to take a progestogen (progesterone or a similar product) along with the estrogen”.1

Umbrella
What may the Hormone Therapy and Estrogen Plus Progestogen Therapy Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Combination Estrogen and Progestin Medicines
  • Combination HT/HRT
  • Combination Hormone Replacement/Hormone Therapy
  • Combined Hormonal Therapy
  • Combined Hormone Replacement Therapy
  • Estrogen Alone
  • Estrogen Plus Progestogen
  • Estrogen With Progestogen Therapy
  • Estrogen and Progestin (Hormone Replacement Therapy)
  • Estrogen-Progestogen Therapy (EPT)
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Oestrogen and Progesterone Therapy

Progesterone

What is progesterone?

DotS the definition of progesterone may vary. The Australasian Menopause Society’s (AMS) definition is:

“Progesterone is the natural hormone found in a woman’s body that helps prepare the endometrium (lining of the uterus) for implantation of a fertilized egg”.2

Progestogen

What is progestogen?

DotS the definition of progestogen may vary. The (Australian) Jean Hailes for Women’s Health’s definition is:

“‘Progestogens’ is the name used to refer to both the natural form of progesterone and the synthetic form, ‘progestin’”.3

Progestin

What is progestin?

DotS the definition of progestin may vary. The AMS’s definition is:

“Progestin is a synthetic hormone which has the actions of progesterone”.4

Uterus

Hormone Therapy and Estrogen Plus Progestogen TherapyWho can choose to use estrogen plus progestogen hormone therapy (HT)?

One of the major points of agreement in the joint statement 15 Top Medical Organizations Agree On Hormone Therapy: 10 Years Have Passed Since Women’s Health Initiative Raised Questions dated 09 July 2012, is:

  • “Women who still have a uterus need to take a progestogen (progesterone or a similar product) along with the estrogen to prevent cancer of the uterus. Women who have had their uterus removed can take estrogen alone”.5

In Combined Menopausal Hormone Therapy (HRT) the AMS also note:

“In a woman with an intact uterus, unopposed oestrogen therapy increases the risk of endometrial hyperplasia and cancer. Therefore, women who have not had a hysterectomy should take a progestogen as well to provide endometrial protection”.6

In Menopause Management: Menopausal Hormone Therapy (MHT) – Types of MHT The JH explain:

“In women who still have their uterus, oestrogen alone can overstimulate the cells lining the uterus, causing an increased risk of endometrial cancer (cancer of the uterus). To remove the risk of overstimulation, women who have not had a hysterectomy need to take progesterone, or a synthetic form known as ‘progestin’, together with the oestrogen”.7

Health Care Provider

If I choose to use estrogen plus progestogen (EPT) what are my risks?

Different women who choose to use EPT can have different risks. It may therefore be in your best interest to also choose to talk to your health care provider about this.

One of the points of consensus about menopausal hormone therapy (MHT) in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.8

In Menopause FAQs: Hormone Therapy – Q. What is hormone therapy? the North American Menopause Society also note:

“A. …You should discuss your individual risks and preferences with your healthcare team to determine whether hormone therapy or alternatives, including FDA-approved nonhormonal therapies, are right for you”.9

What is FDA?

FDA can be an abbreviation for the (United States) Food and Drug Administration.

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy and Estrogen Plus Progestogen Therapy?

In Health Topics A-Z you may find:

Links

Where may I find Links related to Hormone Therapy and Estrogen Plus Progestogen Therapy?

Your Country may have Links similar to:

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. 15 Top Medical Organizations Agree on Hormone Therapy Use: 10 Years Have Passed Since Women’s Health Initiative Raised Questions. 09 July 2012:3. North American Menopause Society, the American Society for Reproductive Medicine and the Endocrine Society https://www.menopause.org/docs/default-document-library/pr12solidarity.pdf?sfvrsn=2 Accessed: 06 July 2020
  2. Glossary of Terms: Progesterone. Content Updated: January 2016. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/381-glossary-of-terms Accessed: 06 July 2020
  3. Menopause Management: Menopausal Hormone Therapy (MHT) – Types of MHT: Oestrogen and Progesterone Therapy.  Last Updated: 07 April 2020 | Last Reviewed: 17 December 2017. Jean for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management/ Accessed: 06 July 2020
  4. Glossary of Terms: Progestin. Content Updated: January 2016. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/381-glossary-of-terms Accessed: 06 July 2020
  5. 15 Top Medical Organizations Agree on Hormone Therapy Use: 10 Years Have Passed Since Women’s Health Initiative Raised Questions. 09 July 2012:3. North American Menopause Society, the American Society for Reproductive Medicine and the Endocrine Society https://www.menopause.org/docs/default-document-library/pr12solidarity.pdf?sfvrsn=2 Accessed: 06 July 2020
  6. Combined Menopausal Hormone Therapy (HRT). Content Updated 12 September 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/267-combined-menopausal-hormone-therapy-mht Accessed: 06 July 2020
  7. Menopause Management: Menopausal Hormone Therapy (MHT) – Types of MHT: Oestrogen and Progesterone Therapy. Last Updated: 07 April 2020 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management/ Accessed: 06 July 2020
  8. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/manage/images/pdf/ba6379e868044bec13015ac2b84f2753.pdf Accessed: 06 July 2020
  9. Menopause FAQs: Hormone Therapy – Q. What is hormone therapy? North American Menopause Society https://www.menopause.org/for-women/menopause-faqs-hormone-therapy-for-menopause-symptoms Accessed: 06 July 2020
Topic Last Updated: 06 July 2020 – Topic Last Reviewed: 06 July 2020
image_pdf