Hormone Therapy and Blood Clots

Hormone Therapy and Blood Clots

“Transdermal routes of administration and lower doses
of hormone therapy may decrease risk
of venous thromboembolism and stroke”.1

Umbrella

What may the Hormone Therapy and Blood Clots Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Blood Clots
  • Deep Vein Thrombosis (DVT)
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Venous Thromboembolism (VTE)
  • Venous Thrombosis

Blood Clot Risk

Hormone Therapy and Blood ClotsWhat is the association between hormone therapy (HT) and blood clot risk?

On page four of Menopause and Menopause Hormone Therapy: 4. Why Is MHT Important? What Are the Risks? the International Menopause Society’s (IMS) Leaflet for Women for World Menopause Day 2024, the IMS elaborate on:

“While MHT offers many benefits, there are some small risks:…

  • …Blood clots: This risk is higher with certain forms of MHT, like tablets”.2

Transdermal

What is the association between transdermal administration of estradial and blood clots?

On page one in The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement, published 07 July 2022, the North American Menopause Society (NAMS) (now the Menopause Society) note:

“Transdermal routes of administration and lower doses of hormone therapy may decrease risk of venous thromboembolism and stroke”.3

On page three in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause, first published online 10 June 2022, one of the recommendations is:

  • “Transdermal administration of estradiol is unlikely to increase the risk of venous thrombosis or stroke above that in non-users and is associated with a lower risk compared with oral administration of estradiol. The transdermal route should therefore be considered as the first choice route of estradiol administration in women with related risk factors”.4

Health Care Provider

If I choose to use HT, what is my risk of blood clots?

On page three of Menopause and Menopause Hormone Therapy: 1. Who Is MHT For? Women With Existing Medical Conditions the IMS explain:

“Women with certain medical histories such as breast cancer and blood clots should talk to their healthcare professional about whether MHT is safe for them. Deciding to use MHT is a personal choice and should involve discussions about the benefits and risks with a healthcare professional who knows your health history”.5

Health Topics A-Z

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In Health Topics A-Z you may find:

Health Topics A-Z

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New or Updated

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  2. BMS TV: Coronary Heart Disease (CHD)
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  7. Consumer Video and Podcast Series: 2024 Consumer Videos and Podcasts – Preparing for Your Menopause Healthcare Visit
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  9. Deciding About Hormone Therapy Use
  10. Deep Vein Thrombosis
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  12. Don’t Ignore These 8 Blood Clot Warning Signs
  13. FAQs: Hormone Therapy for Menopause
  14. FAQs: Preventing Deep Vein Thrombosis
  15. FDA Grand Rounds: FDA Menopausal Hormone Therapy (MHT) Labeling: Historical Context & Recent Changes
  16. Find A Menopause Practitioner [United States and Other]
  17. Find A Practitioner [Australasian Menopause Society i.e. Australia and New Zealand]
  18. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  19. Guidance on Menopausal Hormone Therapy [Video]
  20. HRT Questions Answered
  21. HRT – Types, Doses and Regimens
  22. Hormone Replacement Therapy (HRT): Benefits and Risks
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  26. Hormone Replacement Therapy (HRT): Benefits and Risks
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  28. Hormone Therapy and Thrombosis: What Clinicians May Miss?
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  30. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause
  31. Know Thrombosis
  32. Know Your Blood Clot Risk. Perimenopause, Menopause & Hormone Therapy
  33. Mayo Clinic Minute: Menopause and the Heart Connection [+ Video Courtesy: Mayo Clinic News Network]
  34. Mayo Clinic Minute: Signs of Coronary Artery Disease, How To Reduce Your Risk [+ Video]
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  43. Menopause: Identification and Management [NICE Guideline]
  44. Menopause: Identification and Management [NICE Guideline]Hormone Therapy and Blood Clots
  45. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
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  47. National Center for Complementary and Integrative Health: Herbs At A Glance
  48. National Center for Complementary and Integrative Health: How Safe Is This Product or Practice?
  49. Natural Therapies
  50. Navigating Menopause Care Resource Guide
    Hormone Therapy and Blood Clots
  51. Nonhormone Treatments for Hot Flashes and Night Sweats
  52. Online Events International Menopause Society]: IMS Partnership Symposia Series – Evaluating High-Risk Patients In Menopause At Risk of Cardiovascular Disease (CVD)
  53. Online Events [International Menopause Society]: Past Webinars – 2026: New IMS Recommendations: Evidence-Based Management of Vasomotor Symptoms
  54. Resources: Fact Sheets [Multiply Languages]
  55. Risks and Benefits of MHT
  56. Statin Use and the Risk of Venous Thromboembolism In Women Taking Hormone Therapy
  57. The Basics of Blood Clots: What You Need To Know
  58. The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement
  59. The Women’s Health Initiative Trials: Clinical Messages
  60. Types of Hormone Therapy
  61. Venous Thromboembolism (Blood Clots)
  62. Videos & Podcasts: Videos – Cardiovascular Disease In Women
  63. Videos and Podcasts: Videos – Heart Disease, Risk Factors of Developing Heart Disease, and Can I Take Hormones?
  64. What To Avoid When Taking A Blood Thinner
  65. World Thrombosis Day [13 October]

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement. 07 July 2022:1. North American Menopause Society https://menopause.org/wp-content/uploads/press-release/ht-position-statement-release.pdf Accessed: 15 May 2026
  2. Menopause and Menopause Hormone Therapy: 4. Why Is MHT Important? What Are the Risks? 2024:7. International Menopause Society https://www.imsociety.org/wp-content/uploads/2024/10/2024-WMD-Leaflet_English.pdf Accessed: 15 May 2026
  3. The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement. 07 July 2022:1. North American Menopause Society https://menopause.org/wp-content/uploads/press-release/ht-position-statement-release.pdf Accessed: 15 May 2026
  4. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 10 June 2022:3-4. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 15 May 2026
  5. Menopause and Menopause Hormone Therapy: 1. Who Is MHT For? Women With Existing Medical Conditions. 2024:3. International Menopause Society https://www.imsociety.org/wp-content/uploads/2024/10/2024-WMD-Leaflet_English.pdf Accessed: 15 May 2026
Topic Last Updated: 15 October 2026 – Topic Last Reviewed: 15 May 2026

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