“Transdermal routes of administration
and lower doses of hormone therapy
may decrease risk of venous thromboembolism and stroke”.1
Umbrella
What may the Hormone Therapy and Blood Clots Umbrella include?
Depending on the Source (DotS) this Umbrella may include:
- Blood Clots
- Deep Vein Thrombosis (DVT)
- Hormone Replacement Therapy (HRT)
- Hormone Therapy (HT)
- Menopausal Hormone Therapy (MHT)
- Venous Thromboembolism (VTE)
- Venous Thrombosis
Blood Clot Risk
What is the association between hormone therapy (HT) and blood clot risk?
On page one in Deciding About Hormone Therapy Use: Potential Risks, published July 2022, the North American Menopause Society (NAMS) note:
In Menopause: Diagnosis and Management – Information for the Public: Benefits and Risks of HRT – Blood Clots (Venous Thromboembolism) the (British) National Institute for Health and Care Excellence (NICE) guidelines note:
If you are already at higher risk of blood clots (for example, you are obese) and you are considering HRT, you may be offered patches or gel rather than tablets.
If you have a strong family history of blood clots or if there’s another reason why you are at high risk of blood clots, you may be referred to a haematologist (a doctor who specialises in blood conditions) before considering HRT”.3
Transdermal
What is the association between transdermal administration of estradial and blood clots?
On page one in The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement, published 07 July 2022, the NAMS note:
On page three in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause, first published online 10 June 2022, one of the recommendations is:
- “Transdermal administration of estradiol is unlikely to increase the risk of venous thrombosis or stroke above that in non-users and is associated with a lower risk compared with oral administration of estradiol. The transdermal route should therefore be considered as the first choice route of estradiol administration in women with related risk factors”.5
Health Care Provider
If I choose to use HT, what is my risk of blood clots?
Different women who choose to use HT can have different risks of blood clots. It may therefore be in your best interest to also choose to talk to your health care provider about this.
On page one in Deciding About Hormone Therapy Use the NAMS elaborate on :
Health Topics A-Z
Where may I find Health Topics related to Hormone Therapy and Blood Clots?
In Health Topics A-Z you may find:
Links
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Sources
Where may I find the Sources quoted?
You may find the Sources quoted at:
Sources
- The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement. 07 July 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/press-release/ht-position-statement-release.pdf Accessed: 12 February 2023
- Deciding About Hormone Therapy Use: Potential Risks. 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 12 February 2023
- Menopause Diagnosis and Management: Information for the Public – Benefits and Risks of HRT: Blood Clots (Venous Thrombolembolism). Published Date: 12 November 2015. Last Updated: 05 December 2019. National Institute for Health and Care Excellence https://www.nice.org.uk/guidance/ng23/ifp/chapter/Benefits-and-risks-of-HRT Accessed: 12 February 2023
- The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement. 07 July 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/press-release/ht-position-statement-release.pdf Accessed: 12 February 2023
- Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 10 June 2022:3-4. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 12 February 2023
- Deciding About Hormone Therapy Use. 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 12 February 2023