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Hormone Therapy, Heart Disease and Stroke

October 23, 2025
Health Topics

Hormone Therapy, Heart Disease and Stroke

“Some studies suggest that HT might be good for your heart if you start before age 60 or within 10 years of menopause. However, if you start HT further from menopause…”.1

Umbrella

What may the Hormone Therapy, Heart Disease and Stroke Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Cardiovascular Disease
  • Coronary Heart Disease
  • Heart Disease
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Ischemic Heart Disease
  • Menopausal Hormone Therapy (MHT)
  • Stroke

Cardiovascular Diseases

What are cardiovascular diseases (CVDs)?

DotS the definition of CVDs may vary. The World Health Organization’s definition is:

“CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease, rheumatic heart disease and other conditions. More than four out of five CVD deaths are due to heart attacks and strokes, and one third of these deaths occur prematurely in people under 70 years of age”.2

TypeHormone Therapy, Heart Disease and StrokeHormone Therapy, Heart Disease and Stroke

What can it be important to be clear about with hormone therapy (HT), heart disease and stroke information?

It can be important to be clear about the type of HT – Estrogen Plus Progestogen HT or Estrogen Therapy.

Younger Than Age 60 or Not

What can it also be important to be clear about with HT, heart disease and stroke information?

It can also be important to be clear about whether HT, heart disease and stroke information is about women “younger than age 60 years or within 10 years of menopause”.

Younger Than Age 60

For women younger than age 60 or within 10 years of menopause, what is the association between HT and heart disease and stroke?

On page one in Deciding About Hormone Therapy: Potential Risks, published February 2025, the Menopause Society (formerly the North American Menopause Society) explain:

“As with all medications, HT is associated with some potential risks. For healthy women with bothersome hot flashes aged younger than 60 years or within 10 years of menopause, the benefits of HT generally outweigh the risks. Hormone therapy might slightly increase your risk of stroke or blood clots in the legs or lungs (especially if taken in pill form)”.3

After Age 60

For women after age 60 or further than 10 years from menopause, what is the association between HT, heart disease and stroke?

On page one in Deciding About Hormone Therapy: Potential Risks, the Menopause Society also include:

“Some studies suggest that HT might be good for your heart if you start before age 60 or within 10 years of menopause. However, if you start HT further from menopause or after age 60, HT might slightly increase your risk of heart disease. Although there are risks associated with taking HT, they are not common, and most go away after you stop treatment”.4

The Women’s Health Initiative Randomized Trials and Clinical Practice

What do the Women’s Health Initiative Randomized Trials and Clinical Practice: A Review, note about HT for postmenopausal women to prevent cardiovascular disease or other chronic diseases?

In the Conclusions and Relevance in The Women’s Health Initiative Randomized Trials and Clinical Practice: A Review – Abstract, published 01 May 2024, the authors note:

“For postmenopausal women, the WHI randomized clinical trials do not support menopausal hormone therapy to prevent cardiovascular disease or other chronic diseases. Menopausal hormone therapy is appropriate to treat bothersome vasomotor symptoms among women in early menopause, without contraindications, who are interested in taking hormone therapy”.5

Is there a video explaining these Conclusions and Relevance?

Your Country may have a video similar to:

  • The Women’s Health Initiative Trials: Clinical Messages [17 July 2024]

U.S. Preventative Services Task Force

In 2022, what did the (United States) U.S. Preventative Services Task Force (USPSTF) note in their final recommendations about the use of HT for the primary prevention of chronic conditions in postmenopausal persons?

In Hormone Therapy In Postmenopausal Persons: Primary Prevention of Chronic Conditions, published 01 November 2022, the USPSTF’s recommendations include:


Hormone Therapy, Heart Disease and Stroke“Postmenopausal persons
The USPSTF recommends against the use of combined estrogen and progestin for the primary prevention of chronic conditions in postmenopausal persons”.6

In Hormone Therapy In Postmenopausal Persons: Primary Prevention of Chronic Conditions, published 01 November 2022, the USPSTF’s recommendations also include:

“Postmenopausal persons who have had a hysterectomy
The USPSTF recommends against the use of estrogen alone for the primary prevention of chronic conditions in postmenopausal persons who have had a hysterectomy”.7

Health Care Provider

What if I choose to use HT and would like to lower my risk of heart disease and/or stroke?

If you would like to choose to use HT and lower your risk of heart disease and/or stroke, it may be in your best interest to also choose to talk to your health care provider about this. Together you can discuss your options and if required, agree on who may be the most appropriate health care provider to help you.

Health Topics A-Z

Where may I find Health Topics A-Z related to Hormone Therapy, Heart Disease and Stroke?

In Health Topics A-Z you may find:

Health Topics A-Z

  • Cardiovascular Disease
  • Heart Disease and Women
  • Hormone Therapy
  • Hormone Therapy 2022 Update for Chronic Conditions
  • Hormone Therapy Alternatives
  • Hormone Therapy Benefits and Risks
  • Hormone Therapy Risks
  • Hormone Therapy Videos
  • Menopause and Cardiovascular Disease
  • Stroke

Links

Where may I find Links related to Hormone Therapy, Heart Disease and Stroke?

Your Country may have Links similar to:

Links

This Links List to third party websites is neither comprehensive nor exhaustive. Inclusion on this Links List does not imply endorsement or recommendation. Non-inclusion on this Links List does not imply non-endorsement or non-recommendation. Third party websites are not under the control of Meno Martha International Menopause Directory. Third party websites may contain explicit medical images and/or sexual references. Please read Meno Martha International Menopause Directory’s Links Policy before proceeding to a Link. Please contact Webmaster if you experience a problem with a Link.

New or Updated
  • Can You Take Hormone Replacement Therapy If You Have Heart Disease? [28 February 2025]
  • From Cardiovascular Protection To Cardiovascular Risk: The Metamorphosis of Menopausal Hormone Therapy [03 June 2024]
  • Menopause and Cardiovascular Disease and Using HRT To Treat Menopause Symptoms [07 March 2025]
  • Videos & Podcasts: Videos – Menopause and Hormone Therapy: Current Perspectives and Controversies [18 October 2024]
  • Webinars: Previous – Recommendations on Cardiovascular Risk Assessment [19 November 2024]
  • World Menopause Day 2024: Leaflet for Women – Menopause and Menopause Hormone Therapy [Multiply Languages]
    Hormone Therapy and Heart Disease

  1. Askearlymenopause.org [Ask EM] [+ Video: What Is Early Menopause?]
  2. BMS TV: Coronary Heart Disease (CHD)
  3. BMS TV: Hormone Replacement Therapy (HRT)
  4. Bioidentical Hormones: Are They Safer?
  5. Can You Take Hormone Replacement Therapy If You Have Heart Disease?
  6. Cardiovascular Diseases
  7. Consumer Video and Podcast Series: 2023 Consumer Videos and Podcasts – Menopause and Heart Disease
  8. Consumer Video and Podcast Series: 2023 Consumer Videos and Podcasts – Premature and Early Menopause
  9. Consumer Video and Podcast Series: 2024 Consumer Videos and Podcasts – Preparing for Your Menopause Health Care Visit
  10. DVT (Deep Vein Thrombosis)
  11. Deciding About Hormone Therapy
  12. Deciding About Hormone Therapy Use
  13. Family History
  14. From Cardiovascular Protection To Cardiovascular Risk: The Metamorphosis of Menopausal Hormone Therapy
  15. Find A Menopause Practitioner [United States and Other]
  16. Find A Practitioner [Australasian Menopause Society i.e. Australia and New Zealand]
  17. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  18. Goredforwomen.org [Go Red for Women]
  19. HRT – Types, Doses and Regimens
  20. HRT: Benefits and Risks
  21. Hormone Replacement Therapy
  22. Hormone Replacement Therapy (HRT)
  23. Hormone Replacement Therapy (HRT): Alternatives To Hormone Replacement Therapy (HRT)
  24. Hormone Replacement Therapy (HRT): Benefits and Risks of Hormone Replacement Therapy (HRT)
  25. Hormone Replacement Therapy (HRT): Types of Hormone Replacement Therapy (HRT)
  26. Hormone Therapy
  27. Hormone Therapy In Postmenopausal Persons: Primary Prevention of Chronic Conditions
  28. Hormone Therapy: Is It Right for You?
  29. Hot Flashes
  30. Hot Flashes
  31. Hot Flushes, Night Sweats, Brain Fog? Here’s What We Know About Phytoestrogens for Menopausal Symptoms
  32. How To Find Relief for Hot Flashes At Night
  33. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause
  34. Know Your Numbers
  35. Know Your Numbers: What Is Your Heart Rate?
  36. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – After the Menopause [Other Languages and Formats]
  37. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – Hormone Replacement Therapy (HRT) [+ Video] [Other Languages and Formats]
  38. Life’s Essential 8
  39. Lots of Women Try Herbs Like Black Cohosh for Menopausal Symptoms Like Hot Flushes – But Does It Work?
  40. Mayo Clinic Minute: Help With Hot Flashes Due To Menopause [+ Video]
  41. Mayo Clinic Minute: Menopause and the Heart Connection [+ Video Courtesy: Mayo Clinic News Network]
  42. Menopausal Hormone Therapy
  43. Menopausal Hormone Therapy and Venous Thromboembolism
  44. Menopausal Hormone Therapy, Heart Disease and Stroke
  45. Menopause
  46. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Stages of Menopause: Postmenopause
  47. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  48. Menopause Treatment
  49. Menopause and Cardiovascular Risk
  50. Menopause and HRT: Fact and Fiction
  51. Menopause and Heart Disease
  52. Menopause and Heart Disease: Does Hormone Replacement Therapy (HRT) Affect Your Risk of Heart and Circulatory Disease?
  53. Menopause and Your Health
  54. Mymenoplan.org [My Menoplan, United States]
  55. National Center for Complementary and Integrative Health: Cardiovascular Disease
  56. National Center for Complementary and Integrative Health: Chelation for Coronary Heart Disease: What You Need To Know
  57. National Center for Complementary and Integrative Health: Herbs At A Glance
  58. National Center for Complementary and Integrative Health: How Safe Is This Product or Practice?
  59. Navigating Menopause: Expert Insights and Solutions | Dr Susan Davis | The Proof Podcast EP 245
  60. Numbers You Should Know for Your Heart: What To Ask Your Doctor
  61. Postmenopause
  62. Q&A: Health Changes During Menopause Associated With Increased Cardiovascular Risk
  63. Risks and Benefits of MHT
  64. The Benefits and Risks of Menopause Hormone Therapy for the Cardiovascular System In Postmenopausal Women: A Systematic Review and Meta-Analysis
  65. The Women’s Health Initiative Randomized Trials and Clinical Practice: A Review
  66. The Women’s Health Initiative Trials: Clinical Messages
  67. Videos & Podcasts: Videos – Cardiovascular Disease In Women
  68. Videos and Podcasts: Videos – Interviews: Heart Disease, Risk Factors of Developing Heart Disease, and Can I Take Hormones?
  69. Videos and Podcasts: Videos – Interviews: Prevention of Chronic Diseases In Women: Where Does MHT Fit In?
  70. Webinars: Previous – Cardiovascular Disease
  71. Webinars: Previous – Hormones and Stroke: An Update on Treatment and Risk
  72. Webinars: Previous – Primary Prevention of Cardiovascular Disease With MHT – Where Are We Now?
  73. ‘What’s Normal Has Changed’: Navigating Menopausal Hormone Therapy As CVD Risk Grows
  74. Women & CVD
    Cardiovascular Disease
  75. World Heart Day [29 September]
  76. World Menopause Day
  77. World Menopause Day 2023: Patient Information Leaflet – Cardiovascular Disease: What Women Need To Know [Multiply Languages]
  78. World Menopause Day 2024: Leaflet for Women – Menopause and Menopause Hormone Therapy [Multiply Languages]
  79. Hormone Therapy, Heart Disease and StrokeWorld Menopause Day 2024: Poster for Women – The 5 Ws of Menopause Hormone Therapy (MHT)

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Deciding About Hormone Therapy Use: Potential Risks. 2025:1. Menopause Society https://menopause.org/wp-content/uploads/default-document-library/MenoNote-Deciding-About-HT-2025.pdf Accessed: 23 October 2025
  2. Cardiovascular Diseases. World Health Organization https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1 Accessed: 23 October 2025
  3. Deciding About Hormone Therapy Use: Potential Risks. 2025:1. Menopause Society https://menopause.org/wp-content/uploads/default-document-library/MenoNote-Deciding-About-HT-2025.pdf Accessed: 23 October 2025
  4. Deciding About Hormone Therapy Use: Potential Risks. 2025:1. Menopause Society https://menopause.org/wp-content/uploads/default-document-library/MenoNote-Deciding-About-HT-2025.pdf Accessed: 23 October 2025
  5. Manson, JA. E., Crandall, C. J., Rossouw, J. E., et al. The Women’s Health Initiative Randomized Trials and Clinical Practice: A Review – Abstract: Conclusions and Relevance. 01 May 2024 https://jamanetwork.com/journals/jama/article-abstract/2818206 Accessed: 23 October 2025
  6. Hormone Therapy In Postmenopausal Persons: Primary Prevention of Chronic Conditions. 01 November 2022. U.S. Preventative Services Task Force https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/menopausal-hormone-therapy-preventive-medication Accessed: 23 October 2025
  7. Hormone Therapy In Postmenopausal Persons: Primary Prevention of Chronic Conditions. 01 November 2022. U.S. Preventative Services Task Force https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/menopausal-hormone-therapy-preventive-medication Accessed: 23 October 2025
Topic Last Updated: 23 October 2025 – Topic Last Reviewed: 23 October 2025

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October 23, 2025/by MWD
Tags: Hormone Therapy, Hormone Therapy Alternatives, Hormone Therapy Benefits and Risks, Menopause and Cardiovascular Disease, Stroke Prevention
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