Hormone Therapy and Estrogen Plus Progestogen Therapy

Hormone Therapy and Estrogen Plus Progestogen Therapy

“Because estrogen stimulates the lining of the uterus, women with a uterus need to take an additional hormone, progestogen, or a tissue-selective estrogen complex…”.1

Umbrella

What may the Hormone Therapy and Estrogen Plus Progestogen Therapy Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Combination Estrogen and Progestin Medicines
  • Combination HT/HRT
  • Combination Hormone Replacement/Hormone Therapy
  • Combined Hormonal Therapy
  • Combined Hormone Replacement Therapy
  • Estrogen Plus Progestogen
  • Estrogen With Progestogen Therapy
  • Estrogen and Progestin (Hormone Replacement Therapy)
  • Estrogen-Progestogen Therapy (EPT)
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Oestrogen and Progesterone Therapy

Hormone Therapy

What is hormone therapy (HT) or menopausal hormone therapy (MHT) ?

DotS the definition of HT or MHT may vary. In Treatments for Menopause: Menopausal Hormone Therapy (MHT) – How Does MHT Work? the (Australian) Jean Hailes for Women’s Health’s definition is:

“Menopausal symptoms are caused by lowered levels of certain hormones. MHT is the medical replacement of female hormones oestrogen and progesterone, and sometimes testosterone”.2

Progesterone

What is progesterone?

DotS the definition of progesterone may vary. In Glossary of Terms the Australasian Menopause Society’s (AMS) definition is:

“Progesterone is the ovarian hormone produced by the corpus luteum which prepares the endometrium for implantation of the fertilized egg”.3

Progestogen

What is progestogen?

DotS the definition of progestogen may vary. The AMS’s definition is:

“Progestogen is a hormone which can be natural or synthetic but has a similar effect on a woman’s body as progesterone”.4

Progestin

What is progestin?

DotS the definition of progestin may vary. The AMS’s definition is:

“Progestin is a synthetic hormone which has the actions of progesterone”.5

UterusHormone Therapy and Estrogen Plus Progestogen Therapy

Who can choose to use estrogen plus progestogen hormone therapy (HT)?

On page one in Deciding About Hormone Therapy Use, published February 2025, the Menopause Society (formerly the North American Menopause Society) elaborate on:

“Hormone therapy involves taking estrogen in doses high enough to raise the level of estrogen in your blood in order to treat hot flashes and other symptoms. Because estrogen stimulates the lining of the uterus, women with a uterus need to take an additional hormone, progestogen, or a tissue-selective estrogen complex (TSEC) to protect the uterus”.6

In Treatments for Menopause: Menopausal Hormone Therapy (MHT) – Types of MHT: Oestrogen and Progesterone Therapy the JH explain:

“If you haven’t had a hysterectomy, oestrogen and progesterone are used together, as progesterone reduces the risk of endometrial cancer (cancer of the uterus).

Depending on your situation, your doctor may recommend other combinations of oestrogen and progestogen (including progesterone and other progesterone-like hormones)”.7

Health Care Provider

If I choose to use estrogen plus progestogen (EPT) what are my risks?

Different women who choose to use EPT can have different risks. It may therefore be in your best interest to also choose to talk to your health care provider about this.

On page two in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause first published online 10 June 2022, one of the recommendations is:

  • “The decision whether to take HRT, the dose and duration of its use should be made on an individualised basis after discussing the benefits and risks with each patient. This should be considered in the context of the overall benefits obtained from using HRT including symptom control and improving quality of life as well as considering the bone and cardiovascular benefits associated with HRT use”.8

Health Topics A-Z

Where may I find Health Topics A-Z related to Hormone Therapy and Estrogen Plus Progestogen Therapy?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

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New or Updated

  1. ACOG Explains: Managing Menopause Symptoms [American College of Obstetricians and Gynecologists]
  2. All About Progesterone | Dr Louise Newson
  3. Askearlymenopause.org [Ask EM] [+ Video: What Is Early Menopause?]
  4. BMS TV: Progestogens
  5. Bioidentical Hormones: Are They Safer?
  6. Can HRT Stop Your Periods? [Video]
  7. Consumer Video and Podcast Series: 2023 Consumer Videos and Podcasts – Lifestyle Modification and Prevention of Breast Cancer
  8. Consumer Video and Podcast Series: 2024 Consumer Videos and Podcasts – Preparing for Your Menopause Health Care Visit
  9. Deciding About Hormone Therapy
  10. Deciding About Hormone Therapy Use
  11. EMAS On-Demand Webinars [European Menopause and Andropause Society] [Multiply Languages]: Benefits of Oral Combined MHT for Estrogen Deficiency Symptoms Treatment [Multiply Languages]
  12. Estradiol Skin Patches
  13. Find A Menopause Practitioner [United States and Other]
  14. Find A Practitioner [Australasian Menopause Society i.e. Australia and New Zealand]
  15. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  16. Glossary of Terms
  17. HRT Questions Answered
  18. HRT – Types, Doses and Regimens
  19. HRT: Benefits and Risks
  20. HRT: How To Find the Right Dose & Type | Dr Louise Newson
  21. Handling Hot Flushes and Night Sweats| Dr Louise Newson
  22. Hormone Replacement Therapy (HRT)
  23. Hormone Replacement Therapy (HRT): Benefits and Risks of Hormone Replacement Therapy (HRT)
  24. Hormone Replacement Therapy (HRT): Continuous Combined Hormone Replacement Therapy (HRT) Tablets, Capsules and Patches
  25. Hormone Replacement Therapy (HRT): Continuous Combined Hormone Replacement Therapy (HRT) Tablets, Capsules and Patches – Side Effects of Continuous Combined HRT
  26. Hormone Replacement Therapy (HRT): Oestrogen Tablets, Patches, Gel and Spray
  27. Hormone Replacement Therapy (HRT): Sequential Combined Hormone Replacement Therapy (HRT) Tablets and Patches
  28. Hormone Replacement Therapy (HRT): Sequential Combined Hormone Replacement Therapy (HRT) Tablets and Patches – Side Effects of Sequential Hormone Replacement Therapy (HRT)
  29. Hormone Replacement Therapy (HRT): Types of Hormone Replacement Therapy (HRT)
  30. Hormone Replacement Therapy (HRT): Utrogestan (Micronised Progesterone)
  31. Hormone Replacement Therapy (HRT): Utrogestan (Microsecond Progesterone) – Side Effects of Utrogestan
  32. Hormone Therapy: Is It Right for You?
  33. Hot Flashes
  34. Hot Flashes
  35. Hot Flashes: What Can I Do? [+ Video: What Are the Signs and Symptoms of Menopause?]
  36. International Menopause Society (IMS) Recommendations and Key Messages on Women’s Midlife Health and Menopause
  37. Menopause
  38. Menopause
  39. Menopause
    Black Women’s Menopause
  40. Menopause Definitions
  41. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
  42. Menopause Map: Downloadable Resources – Stages of Menopause: Medication Tracker
    Hormone Therapy and Estrogen Plus Progestogen Therapy
  43. Menopause Symptoms and Relief
  44. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  45. Menopause Treatment
  46. Menopause Treatments: What Works, What Doesn’t
  47. Menopause What Are the Symptoms?
  48. Menopause: Diagnosis & Treatment
  49. Menopause: Identification and Management [NICE Guideline]
  50. Menopause: Identification and Management [NICE Guideline]Hormone Therapy
  51. Navigating Menopause: Honest Answers To All Your Questions [+ Video: What To Expect In Menopause]
  52. Navigating Menopause Care Resource Guide
    Hormone Therapy
  53. Online Events [International Menopause Society]: IMS Partnership Symposia Series – What’s Hot? Options for Treatment of Hot Flushes 2025
  54. Practical HRT Tips | Dr Louise Newson
  55. Progesterone Intolerance | Dr Louise Newson
  56. Progestin Sensitivity / Progesterone Intolerance
  57. Slynd As Endometrial Protection [16 April 2025]
  58. The 2023 Practitioner’s Toolkit for Managing Menopause
  59. Slynd As Endometrial Protection
  60. Treatments for Menopause
  61. Understanding Hormone Therapy for Menopausal Symptoms
  62. Updated 2024 NICE Menopause Guidance Summary
  63. Video: Hormone Therapy Protects Bone, Heart, Brain Health During Menopause
  64. Video & Podcast Library: Videos – World Menopause Day 2024: Menopause and Hormone Therapy: Current Perspectives and Controversies
  65. Videos & Podcasts: Videos – Menopause and Hormone Therapy: Current Perspectives and Controversies
  66. What Are the Benefits and Risks of HRT?
  67. World Menopause Day 2024: Leaflet for Women – Menopause and Menopause Hormone Therapy [Multiply Languages]
    Hormone Therapy and Estrogen Plus Progestogen Therapy
  68. World Menopause Day 2024: Poster for Women – The 5 Ws of Menopause Hormone Therapy (MHT)
    Hormone Therapy and Estrogen Plus Progestogen Therapy
  69. World Menopause Day 2024: The IMS White Paper: Menopause and MHT In 2024: Addressing the Key Controversies [Multiply Languages]

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Deciding About Hormone Therapy Use. 2025:1. Menopause Society https://menopause.org/wp-content/uploads/default-document-library/MenoNote-Deciding-About-HT-2025.pdf Accessed: 17 February 2026
  2. Treatments for Menopause: Menopausal Hormone Therapy (MHT) – How Does MHT Work? Last Updated: 13 May 2025 | Last Reviewed: 22 April 2025. Jean Hailes for Women’s Health https://www.jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 17 February 2026
  3. Glossary of Terms: Progesterone. 15 February 2022. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/381-glossary-of-terms Accessed: 17 February 2026
  4. Glossary of Terms: Progestogen. 15 February 2022. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/381-glossary-of-terms Accessed: 17 February 2026
  5. Glossary of Terms: Progestin. 15 February 2022. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/381-glossary-of-terms Accessed: 17 February 2026
  6. Deciding About Hormone Therapy Use. 2025:1. Menopause Society https://menopause.org/wp-content/uploads/default-document-library/MenoNote-Deciding-About-HT-2025.pdf Accessed: 17 February 2026
  7. Treatments for Menopause: Menopausal Hormone Therapy (MHT) – Types of MHT: Oestrogen and Progesterone Therapy. Last Updated: 13 May 2025 | Last Reviewed: 22 April 2025. Jean Hailes for Women’s Health https://www.jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 17 February 2026
  8. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 10 June 2022:3-4. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 17 February 2026
Topic Last Updated: 17 February 2026 – Topic Last Reviewed: 17 February 2026

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