Hormone Therapy and SERMs

“Raloxifene (marketed as Evista), a mixed estrogen activator (agonist) and blocker (antagonist), acts as an activator in bone and as a blocker in the uterus and…”.1

Umbrella
What may the Hormone Therapy and SERMs Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Oestrogen Agonist/Antagonists
  • Selective Estrogen Receptor Modulators (SERMs)

Definition

What is SERMs?

DotS the definition of SERMs may vary. The Australasian Menopause Society’s (AMS) definition is:

“SERMs is “shorthand” for a class of drug called selective oestrogen receptor modulators”.2

Treatment

What can SERMs be used to treat?

In SERMs – Their Role In Menopause Management the AMS explain:

“They are a versatile group of drugs that can be used to treat/ prevent a number of conditions such as osteoporosis, infertility and hormone responsive cancers. Within the SERM class, different compounds have differing agonist or antagonist effects at the oestrogen receptor in different tissues, therefore they are “selective””.3

Raloxifene

What is Raloxifene?

On page two in SERMs FAQs – Q: I Have Low Bone Mineral Density. Is There A SERM That Can Help? the North American Menopause Society (NAMS) elaborate on:

“A: Raloxifene (marketed as Evista), a mixed estrogen activator (agonist) and blocker (antagonist), acts as an activator in bone and as a blocker in the uterus and breast. It is FDA approved to prevent and treat osteoporosis and to reduce the risk of invasive breast cancer in women who have osteoporosis or who are at high risk of breast cancer. Its benefits include slowing the process of bone loss and rebuilding (called bone turnover), increasing bone density, and reducing the risk of vertebral fractures caused by osteoporosis”.4

What is FDA?

FDA can be an abbreviation for the (United States) Food and Drug Administration.

SERMs FAQs

Is there a SERMs FAQs (Frequently Asked Questions)?

In What Selective Estrogen Receptor Modulators (SERMs) Can Do for You: Frequently Asked Questions About SERMs you can “get answers to the 12-most frequently asked questions about SERMs” in SERMs FAQs.

Health Care Provider

What if I choose to use SERMs?

If you choose to use SERMs, it may be in your best interest to also choose to talk to your health care provider about this.

On page two in SERMS FAQs: Q: So What Is the Bottom Line? the NAMS explain:

Hormone Therapy and SERMs

“A: Talk to your clinician about whether a SERM might be right for you if you are experiencing hot flashes and have a history of breast cancer, have been told you have low bone density, want to avoid bleeding or change in breast density but need relief from hot flashes, or sex is painful for you. Write your questions and all your symptoms down before your visit to discuss with your clinician. There is help out there”.5

One of the points of consensus about menopausal hormone therapy (MHT) in the Revised Global Consensus Statement on Menopausal Hormone Therapy – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.6

What is VTE?

VTE can be an abbreviation for Venous Thromboembolism.

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy and SERMs?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

Where may I find Links related to Hormone Therapy and SERMs?

Your Country may have Links similar to:

Links

This Links List to third party websites is neither comprehensive nor exhaustive. Inclusion on this Links List does not imply endorsement or recommendation. Non-inclusion on this Links List does not imply non-endorsement or non-recommendation. Third party websites are not under the control of Meno Martha International Menopause Directory. Third party websites may contain explicit medical images and/or sexual references. Please read Meno Martha International Menopause Directory’s Links Policy before proceeding to a Link. Please contact Webmaster if you experience a problem with a Link.

  1. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 6. Myth – Complementary Medicines and Therapies Are As Effective As MHT and Safer
  2. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 7. Myth – Compounded Bioidentical Hormone Therapy Is Safer Than Conventional MHT
  3. BMS & WHC’s 2020 Recommendations on Hormone Replacement Therapy In Menopausal Women
  4. Bioidentical Custom Compounded Hormone Therapy
  5. Bioidentical Hormone Therapy
  6. Bioidentical Hormones Explained – A British Menopause Society Video
  7. Bioidentical Hormones: Are They Safer?
  8. Breastcancer.org [United States]
  9. Combined Menopausal Hormone Therapy (MHT)
  10. Complementary Medicine Options for Menopausal Symptoms
  11. Complementary and Alternative Therapies Explained – A British Menopause Society Video
  12. Deciding About Hormone Therapy Use
  13. Does Osteoporosis Run In Your Family?
  14. Evista
  15. Evista
  16. HRT
  17. HRT and Alternatives
  18. HRT: Benefits and Risks
  19. Hormone Help Desk: ET, EPT, and More
  20. Hormone Replacement Therapy
  21. Hormone Replacement Therapy (HRT) Explained – A British Menopause Society Video
  22. Hormone Replacement Therapy (HRT): Risks
  23. Hormone Therapy: Is It Right for You?
  24. Index To Drug-Specific Information [United States]
  25. Information About Menopause [Multiply Languages] [Videos]
  26. International Osteoporosis Foundation: Osteoporosis
  27. Lifestyle and Behaviour Changes for Menopausal Symptoms
  28. Lifestyle and Behavioural Modifications for Menopausal Symptoms
  29. Menopause
  30. Menopause
  31. Menopause
  32. Menopause
  33. Menopause & Herbs
  34. Menopause Explained – A British Menopause Society Video
  35. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  36. Menopause FAQs: Your Health After Menopause
  37. Menopause Management: Hormone Replacement Therapy (HRT)
  38. Menopause Treatment
  39. Menopause and Your Health
  40. Menopause – How Will It Affect My Health? [Multiply Languages] [Multiply Languages] [Video]
  41. Menopause – Is Menopausal Hormone Therapy (HRT) Safe? [Multiply Languages] [Video]
  42. Menopause – Non-Hormonal Treatment Options [Multiply Languages] [Video]
  43. Menopause – What Are the Symptoms? [Multiply Languages] [Video]
  44. Menopause – What Is Menopausal Hormone Therapy (HRT)? [Multiply Languages] [Video]
  45. Menopause: Diagnosis & Treatment
  46. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  47. Menopause: Hormone Replacement Therapy (HRT) [Video Interview Stories]
  48. Menopause: Medicines To Help You
  49. Menopause: Menopause – Hormone Treatments
  50. Menopause: Non-HRT and Lifestyle Options [Video Interview Stories]
  51. Menopause: Non-Hormonal Treatment & Relief for Hot Flashes
  52. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use
  53. National Center for Complementary and Integrative Health: Know the Science: How Medications and Supplements Can Interact
  54. National Center for Complementary and Integrative Health: Menopausal Symptoms: In Depth
  55. National Osteoporosis Month [May, United States]
  56. Natural Therapies & Supplements
  57. Non-Hormonal Treatment Options for Menopausal Symptoms
  58. NonHormonal Management of Menopause-Associated Vasomotor Symptoms: 2015 Position Statement of the North American Menopause Society
  59. NonHormonal Treatments for Menopausal Symptoms
  60. Oestrogen Only Menopausal Hormone Therapy
  61. Osteoporosis
  62. Osteoporosis Treatment
  63. Osteoporosis: Bone Health Following the Menopause
  64. Raloxifene
  65. Raloxifene (Oral Route)
  66. Revised Global Consensus Statement on Menopausal Hormone Therapy
  67. Risks and Benefits of MHT
  68. SERMs FAQs
  69. SERMs – Their Role In Menopause Management
  70. The Beneficial and Adverse Effects of Raloxifene In Menopausal Women: A Mini Review
  71. Video Series-2019 – Bone Density Facts
  72. Video Series-2020 – Bone Health What You Need To Know
  73. Video Series-2021 – What Women Need To Know About Hormone Therapies
  74. Webinars: Other Webinars – Understanding Bone Densitometry
  75. Webinars: Symposia – 2021 Vision: Practical Steps To Optimize Your Benefit-Risk. Discussions for A New Decade
  76. What Is Osteoporosis and What Causes It? [+ Video: What Is Osteoporosis]
  77. What Selective Estrogen Receptor Modulators (SERMs) Can Do for You: Discussion About SERMs With the Experts [Video]

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. SERMs – Their Role In Menopause Management. Content Updated May 2017. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/971-serms-their-role-in-menopause-management Accessed: 18 July 2021
  2. SERMs – Their Role In Menopause Management. Content Updated May 2017. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/971-serms-their-role-in-menopause-management Accessed: 18 July 2021
  3. SERMs – Their Role In Menopause Management. Content Updated May 2017. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/971-serms-their-role-in-menopause-management Accessed: 18 July 2021
  4. SERMs FAQs – Q: I Have Low Bone Mineral Density. Is There A SERM That Can Help? Page 2. North American Menopause Society https://www.menopause.org/docs/default-source/for-women/serms-faqs.pdf Accessed: 18 July 2021
  5. SERMs FAQs – Q: So What Is the Bottom Line? Page 3. North American Menopause Society https://www.menopause.org/docs/default-source/for-women/serms-faqs.pdf Accessed: 18 July 2021
  6. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/wp-content/uploads/2020/08/global-consensus-hrt-2016-06.pdf Accessed: 18 July 2021

Topic Last Updated: 18 July 2021 – Topic Last Reviewed: 18 July 2021
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