Hormone Therapy and SERMs

“Raloxifene (marketed as Evista), a mixed estrogen activator (agonist) and blocker (antagonist), acts as an activator in bone and as a blocker in the uterus and…”.1

Umbrella
What may the Hormone Therapy and SERMs Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Oestrogen Agonist/Antagonists
  • Selective Estrogen Receptor Modulators (SERMs)

Definition

What is SERMs?

DotS the definition of SERMs may vary. The Australasian Menopause Society’s (AMS) definition is:

“SERMs is “shorthand” for a class of drug called selective oestrogen receptor modulators”.2

Treatment

What can SERMs be used to treat?

In SERMs – Their Role In Menopause Management the AMS explain:

“They are a versatile group of drugs that can be used to treat/ prevent a number of conditions such as osteoporosis, infertility and hormone responsive cancers. Within the SERM class, different compounds have differing agonist or antagonist effects at the oestrogen receptor in different tissues, therefore they are “selective””.3

Raloxifene

What is Raloxifene?

On page two in SERMs FAQs – Q: I Have Low Bone Mineral Density. Is There A SERM That Can Help? the North American Menopause Society (NAMS) elaborate on:

“A: Raloxifene (marketed as Evista), a mixed estrogen activator (agonist) and blocker (antagonist), acts as an activator in bone and as a blocker in the uterus and breast. It is FDA approved to prevent and treat osteoporosis and to reduce the risk of invasive breast cancer in women who have osteoporosis or who are at high risk of breast cancer. Its benefits include slowing the process of bone loss and rebuilding (called bone turnover), increasing bone density, and reducing the risk of vertebral fractures caused by osteoporosis”.4

What is FDA?

FDA can be an abbreviation for the (United States) Food and Drug Administration.

SERMs FAQs

Is there a SERMs FAQs (Frequently Asked Questions)?

In What Selective Estrogen Receptor Modulators (SERMs) Can Do for You: Frequently Asked Questions About SERMs you can “get answers to the 12-most frequently asked questions about SERMs” in SERMs FAQs.

Health Care Provider

What if I choose to use SERMs?

If you choose to use SERMs, it may be in your best interest to also choose to talk to your health care provider about this.

On page two in SERMS FAQs: Q: So What Is the Bottom Line? the NAMS explain:

Hormone Therapy and SERMs

“A: Talk to your clinician about whether a SERM might be right for you if you are experiencing hot flashes and have a history of breast cancer, have been told you have low bone density, want to avoid bleeding or change in breast density but need relief from hot flashes, or sex is painful for you. Write your questions and all your symptoms down before your visit to discuss with your clinician. There is help out there”.5

One of the points of consensus about menopausal hormone therapy (MHT) in the Revised Global Consensus Statement on Menopausal Hormone Therapy – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.6

What is VTE?

VTE can be an abbreviation for Venous Thromboembolism.

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy and SERMs?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

Where may I find Links related to Hormone Therapy and SERMs?

Your Country may have Links similar to:

Links

This Links List to third party websites is neither comprehensive nor exhaustive. Inclusion on this Links List does not imply endorsement or recommendation. Non-inclusion on this Links List does not imply non-endorsement or non-recommendation. Third party websites are not under the control of Meno Martha International Menopause Directory. Third party websites may contain explicit medical images and/or sexual references. Please read Meno Martha International Menopause Directory’s Links Policy before proceeding to a Link. Please contact Webmaster if you experience a problem with a Link.

  1. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 6. Myth – Complementary Medicines and Therapies Are As Effective As MHT and Safer
  2. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 7. Myth – Compounded Bioidentical Hormone Therapy Is Safer Than Conventional MHT
  3. BMS & WHC’s 2020 Recommendations on Hormone Replacement Therapy In Menopausal Women
  4. Bioidentical Custom Compounded Hormone Therapy
  5. Bioidentical Hormone Therapy
  6. Bioidentical Hormones Explained – A British Menopause Society Video
  7. Bioidentical Hormones: Are They Safer?
  8. Breastcancer.org [United States]
  9. Combined Menopausal Hormone Therapy (MHT)
  10. Complementary Medicine Options for Menopausal Symptoms
  11. Complementary and Alternative Therapies Explained – A British Menopause Society Video
  12. Deciding About Hormone Therapy Use
  13. Does Osteoporosis Run In Your Family?
  14. Evista
  15. Evista
  16. HRT
  17. HRT and Alternatives
  18. HRT: Benefits and Risks
  19. Hormone Help Desk: ET, EPT, and More
  20. Hormone Replacement Therapy
  21. Hormone Replacement Therapy (HRT) Explained – A British Menopause Society Video
  22. Hormone Replacement Therapy (HRT): Risks
  23. Hormone Therapy: Is It Right for You?
  24. Index To Drug-Specific Information [United States]
  25. International Osteoporosis Foundation: About Osteoporosis
  26. Lifestyle and Behaviour Changes for Menopausal Symptoms
  27. Lifestyle and Behavioural Modifications for Menopausal Symptoms
  28. Menopause
  29. Menopause
  30. Menopause
  31. Menopause
  32. Menopause & Herbs
  33. Menopause Explained – A British Menopause Society Video
  34. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  35. Menopause FAQs: Your Health After Menopause
  36. Menopause Management: Hormone Replacement Therapy (HRT)
  37. Menopause Treatment
  38. Menopause and Your Health
  39. Menopause: Diagnosis & Treatment
  40. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  41. Menopause: How Will It Affect My Health? [Multiply Languages] [Multiply Languages] [Video]
  42. Menopause: Is Menopausal Hormone Therapy (HRT) Safe? [Multiply Languages] [Video]
  43. Menopause: Medicines To Help You
  44. Menopause: Menopause – Hormone Treatments
  45. Menopause: Non-Hormonal Treatment & Relief for Hot Flashes
  46. Menopause: Non-Hormonal Treatment Options [Multiply Languages] [Video]
  47. Menopause: What Are the Symptoms? [Multiply Languages] [Video]
  48. Menopause: What Is Menopausal Hormone Therapy (HRT)? [Multiply Languages] [Video]
  49. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use
  50. National Center for Complementary and Integrative Health: Know the Science: How Medications and Supplements Can Interact
  51. National Center for Complementary and Integrative Health: Menopausal Symptoms: In Depth
  52. National Osteoporosis Month [May, United States]
  53. Natural Therapies & Supplements
  54. Non-Hormonal Treatment Options for Menopausal Symptoms
  55. NonHormonal Management of Menopause-Associated Vasomotor Symptoms: 2015 Position Statement of the North American Menopause Society
  56. NonHormonal Treatments for Menopausal Symptoms
  57. Oestrogen Only Menopausal Hormone Therapy
  58. Osteoporosis
  59. Osteoporosis Treatment
  60. Osteoporosis: Bone Health Following the Menopause
  61. Raloxifene
  62. Raloxifene (Oral Route)
  63. Revised Global Consensus Statement on Menopausal Hormone Therapy
  64. Risks and Benefits of MHT
  65. SERMs FAQs
  66. SERMs – Their Role In Menopause Management
  67. The Beneficial and Adverse Effects of Raloxifene In Menopausal Women: A Mini Review
  68. The Menopause: Hormone Replacement Therapy (HRT) [+ Video: Is HRT Bad for You?]
  69. Video Series-2021: What Women Need to Know About Hormone Therapies
  70. Videos and Podcasts: World Menopause Day 2021 – Interviews: Bone Health
  71. Videos and Podcasts: World Menopause Day 2021 – Interviews: Bone Health What Why and How
  72. Webinars: Previous – 2021 Vision: Practical Steps To Optimize Your Benefit-Risk. Discussions for A New Decade
  73. Webinars: Previous – Breast Cancer
  74. Webinars: Previous – Update on Bone Health
  75. What Is Osteoporosis and What Causes It? [+ Video: What Is Osteoporosis]
  76. What Selective Estrogen Receptor Modulators (SERMs) Can Do for You: Discussion About SERMs With the Experts [Video]
  77. World Menopause Day: Patient Information Leaflet: Update on Bone Health [Multiply Languages] Hormone Therapy and SERMs

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. SERMs – Their Role In Menopause Management. Content Updated May 2017. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/971-serms-their-role-in-menopause-management Accessed: 02 January 2022
  2. SERMs – Their Role In Menopause Management. Content Updated May 2017. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/971-serms-their-role-in-menopause-management Accessed: 02 January 2022
  3. SERMs – Their Role In Menopause Management. Content Updated May 2017. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/971-serms-their-role-in-menopause-management Accessed: 02 January 2022
  4. SERMs FAQs – Q: I Have Low Bone Mineral Density. Is There A SERM That Can Help? Page 2. North American Menopause Society https://www.menopause.org/docs/default-source/for-women/serms-faqs.pdf Accessed: 02 January 2022
  5. SERMs FAQs – Q: So What Is the Bottom Line? Page 3. North American Menopause Society https://www.menopause.org/docs/default-source/for-women/serms-faqs.pdf Accessed: 02 January 2022
  6. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/wp-content/uploads/2020/08/global-consensus-hrt-2016-06.pdf Accessed: 02 January 2022

Topic Last Updated: 02 January 2022 – Topic Last Reviewed: 02 January 2022
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