“The Women’s Health Initiative (WHI) is a long-term national health study that has focused on strategies for preventing the major causes of death, disability, and…”.1

Date

What can it be important to be clear about with hormone therapy (HT) information?

I think it can be important to be clear about the date of all information including the date of HT information, because this information may have been updated.

Symptoms or Chronic Conditions

What can it also be important to be clear about with HT information?

I think it can also be important to be clear about whether HT information is about the use of HT for the management of menopausal symptoms such as hot flushes, night sweats and vaginal dryness; or for the prevention of chronic conditions such as cardiovascular disease, cancer and osteoporosis.

Background

What is the (United States) Women’s Health Initiative (WHI)?

In About WHI the WHI elaborate on:

“The Women’s Health Initiative (WHI) is a long-term national health study that has focused on strategies for preventing the major causes of death, disability, and frailty in older women, specifically heart disease, cancer, and osteoporotic fractures”.2

Original WHI Study

In the original WHI study, what were the three parts?

In Women’s Health Initiative (WHI): What Is the Goal of the WHI? the (United States) National Heart, Lung, and Blood Institute (NHLBI) explain:

“The original WHI study had three parts—a clinical trial, an observational study, and a community prevention study—and completed data collection in 2005”.3

Hormone Therapy Trials

What were the WHI’s hormone therapy trials?

In About WHI the WHI elaborate on:

  • Women’s Health Initiative“Hormone Therapy Trials (HT): This component examined the effects of combined hormones or estrogen alone on the prevention of heart disease and osteoporotic fractures, and associated risk for breast cancer. Women participating in this component took hormone pills or a placebo (inactive pill) until the Estrogen plus Progestin and Estrogen Alone trials were stopped early in July 2002 and March 2004, respectively. All HT participants continued to be followed without intervention until close-out”.4

Expectations

What did the WHI’s researchers expect to find in their two studies in the hormone trial?

On page one in the NAMS Journal Menopause Reflects on the WHI Ten Years Later the North American Menopause Society explain:

“Researchers expected to find that hormones prevented chronic conditions of aging in women, including heart disease. Instead, they found that hormones produced a mix of risks and benefits”.5

Health Care Provider

What if I choose to use menopausal hormone therapy (MHT)?

If you choose to use MHT, it may be in your best interest to also choose to talk to your health care provider about this.

One of the points of consensus in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section A: Benefit/Risk Profile of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

Women’s Health Initiative

  • “MHT, including tibolone and the combination of conjugated equine estrogens and bazedoxifene (CE/BZA), is the most effective treatment for vasomotor symptoms (VMS) associated with menopause at any age, but benefits are more likely to outweigh risks if initiated for symptomatic women before the age of 60 years or within 10 years after menopause”.6

Health Topics A-Z

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Links

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Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. About WHI. Women’s Health Initiative https://www.whi.org/about/SitePages/About%20WHI.aspx Accessed: 03 May 2020
  2. About WHI. Women’s Health Initiative https://www.whi.org/about/SitePages/About%20WHI.aspx Accessed: 03 May 2020
  3. Women’s Health Initiative (WHI): What Is the Goal of the WHI? National Heart, Lung, and Blood Institute https://www.nhlbi.nih.gov/science/womens-health-initiative-whi Accessed: 03 May 2020
  4. About WHI. Women’s Health Initiative https://www.whi.org/about/SitePages/About%20WHI.aspx Accessed: 03 May 2020
  5. NAMS Journal Menopause Reflects on the WHI Ten Years Later. 29 May 2012:1. North American Menopause Society https://www.menopause.org/docs/default-document-library/pr12whi.pdf?sfvrsn=2 Accessed: 03 May 2020
  6. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section A: Benefit/Risk Profile of MHT. Climacteric, 2016;19:4:313 https://www.imsociety.org/manage/images/pdf/ba6379e868044bec13015ac2b84f2753.pdf Accessed: 03 May 2020
Topic Last Updated: 03 May 2020 – Topic Last Reviewed: 03 May 2020
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