“The Women’s Health Initiative (WHI) is a long-term national health study that has focused on strategies for preventing the major causes of death, disability, and…”.1

Date

What can it be important to be clear about with hormone therapy (HT) information?

I think it can be important to be clear about the date of all information including the date of HT information, because this information may have been updated.

Symptoms or Chronic Conditions

What can it also be important to be clear about with HT information?

I think it can also be important to be clear about whether HT information is about the use of HT for the management of menopausal symptoms such as hot flushes, night sweats and vaginal dryness; or for the prevention of chronic conditions such as cardiovascular disease, cancer and osteoporosis.

Background

What is the (United States) Women’s Health Initiative (WHI)?

In About WHI the WHI elaborate on:

“The Women’s Health Initiative (WHI) is a long-term national health study that has focused on strategies for preventing the major causes of death, disability, and frailty in older women, specifically heart disease, cancer, and osteoporotic fractures”.2

Original WHI Study

In the original WHI study, what were the three parts?

In Women’s Health Initiative (WHI): What Is the Goal of the WHI? the (United States) National Heart, Lung, and Blood Institute (NHLBI) explain:

“The original WHI study had three parts—a clinical trial, an observational study, and a community prevention study—and completed data collection in 2005”.3

Hormone Therapy Trials

What were the WHI’s hormone therapy trials?

In About WHI the WHI elaborate on:

  • Women’s Health Initiative“Hormone Therapy Trials (HT): This component examined the effects of combined hormones or estrogen alone on the prevention of heart disease and osteoporotic fractures, and associated risk for breast cancer. Women participating in this component took hormone pills or a placebo (inactive pill) until the Estrogen plus Progestin and Estrogen Alone trials were stopped early in July 2002 and March 2004, respectively. All HT participants continued to be followed without intervention until close-out”.4

Expectations

What did the WHI’s researchers expect to find in their two studies in the hormone trial?

On page one in the NAMS Journal Menopause Reflects on the WHI Ten Years Later the North American Menopause Society explain:

“Researchers expected to find that hormones prevented chronic conditions of aging in women, including heart disease. Instead, they found that hormones produced a mix of risks and benefits”.5

Health Care Provider

What if I choose to use menopausal hormone therapy (MHT)?

If you choose to use MHT, it may be in your best interest to also choose to talk to your health care provider about this.

One of the points of consensus in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section A: Benefit/Risk Profile of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

Women’s Health Initiative

  • “MHT, including tibolone and the combination of conjugated equine estrogens and bazedoxifene (CE/BZA), is the most effective treatment for vasomotor symptoms (VMS) associated with menopause at any age, but benefits are more likely to outweigh risks if initiated for symptomatic women before the age of 60 years or within 10 years after menopause”.6

Health Topics A-Z

Where may I find Health Topics related to the Women’s Health Initiative?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

Where may I find Links related to Women’s Health Initiative?

Your Country may have Links similar to:

Links

This Links List to third party websites is neither comprehensive nor exhaustive. Inclusion on this Links List does not imply endorsement or recommendation. Non-inclusion on this Links List does not imply non-endorsement or non-recommendation. Third party websites are not under the control of Meno Martha International Menopause Directory. Third party websites may contain explicit medical images and/or sexual references. Please read Meno Martha International Menopause Directory’s Links Policy before proceeding to a Link. Please contact Webmaster if you experience a problem with a Link.
  1. 15 Top Medical Organizations Agree on Hormone Therapy Use: 10 Years Have Passed Since Women’s Health Initiative Raised Questions
  2. 2016 IMS Recommendations on Women’s Midlife Health and Menopause Hormone Therapy
  3. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 2. Myth – Breast Cancer Is the Most Common Cause of Death In Postmenopausal Women
  4. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 3. Misunderstanding – One-Quarter of Women Who Take MHT Get Breast Cancer
  5. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 4. Misunderstanding – MHT Increases the Risk of Heart Disease
  6. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 6. Myth – Complementary Medicines and Therapies Are As Effective As MHT and Safer
  7. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 7. Myth – Compounded Bioidentical Hormone Therapy Is Safer Than Conventional MHT
  8. A Decade After the Women’s Health Initiative–the Experts Do Agree
  9. Bioidentical Hormones Explained – A British Menopause Society Video
  10. Bioidentical Hormones: Are They Safer?
  11. Combined Menopausal Hormone Therapy (MHT)
  12. Complementary Medicine Options for Menopausal Symptoms
  13. Complementary and Alternative Therapies Explained – A British Menopause Society Video
  14. Coronary Heart Disease (CHD) Explained – A British Menopause Society Video
  15. Deciding About Hormone Therapy
  16. Deciding About Hormone Therapy Use
  17. Decidir Sobre La Hormonoterapia
  18. Estrogen & Hormones: Postmenopausal Hormone Replacement Therapy
  19. Fact Sheets and Downloads: Additional Downloadable Resources – Vaginal Estrogen Therapy
  20. Facts About Heart Disease In Women
  21. Goredforwomen.org [Go Red for Women]
  22. HRT and Breast Cancer: Overall Risks and Benefits Explained – A British Menopause Society Video
  23. HRT and the Risk of Breast Cancer Explained – A British Menopause Society Video
  24. HRT: Summary
  25. HRT: The History – HRT Timeline
  26. Hormone Help Desk: ET, EPT, and More
  27. Hormone Replacement Therapy (HRT)
  28. Hormone Replacement Therapy (HRT) Explained – A British Menopause Society Video
  29. Hormone Replacement Therapy (HRT): Risks
  30. Hormone Replacement Therapy (HRT): Types
  31. Hormone Replacement Therapy Safe, Despite Rare Blood Clot Risks From Tablets
  32. Hormone Therapy In Postmenopausal Women: Primary Prevention of Chronic Conditions
  33. Hormone Therapy Trials (HT)
  34. Hormone Therapy: Is It Right for You?
  35. Hormones After Age 65 Are OK for Some Women
  36. Hot Flashes: Manage Without Medication?
  37. Hot Flashes: What Can I Do?
  38. Hot Stuff: What’s New About Hot Flashes?
  39. Index To Drug-Specific Information [United States]
  40. Information About Menopause [Multiply Languages] [Videos]
  41. Ischemic Heart Disease: What Should Women Know?
  42. Know Your Numbers? They Could Just Save Your Life
  43. Know Your Risk
  44. MHT and Breast Cancer Risk
  45. Making Sense of Menopausal Hormone Therapy Means Understanding the Benefits As Well As the Risks
  46. Menopausal Hormone Therapy and Cancer
  47. Menopause
  48. Menopause
  49. Menopause
  50. Menopause Explained – A British Menopause Society Video
  51. Menopause FAQs: Expert Answers To Frequently Asked Questions About Menopause
  52. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  53. Menopause FAQs: Hormone Therapy for Menopause Symptoms – Q. Who should not use hormone therapy?
  54. Menopause Hormone Therapy: Who Shouldn’t Take It?
  55. Menopause Management: Menopause Hormone Therapy (MHT) – Benefits & Risks of MHT
  56. Menopause Management: Menopause Hormone Therapy (MHT) – What Are the Risks of MHT?
  57. Menopause Matters
  58. Menopause Symptoms and Relief
  59. Menopause Treatment
  60. Menopause – Is Menopausal Hormone Therapy (HRT) Safe? [Multiply Languages] [Video]
  61. Menopause – What Is Menopausal Hormone Therapy (HRT)? [Multiply Languages] [Video]
  62. Menopause: Diagnosis & Treatment
  63. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  64. Menopause: Medicines To Help You
  65. Menopause: Menopause – Hormone Treatments
  66. Misinterpretation of WHI Results Decreased Use of Hormones, Even In Women Not At Risk [Women’s Health Initiative]
  67. NAMS Journal Menopause Reflects on the WHI 10 Years Later
  68. National Center for Complementary and Integrative Health: How Safe Is This Product or Practice?
  69. Non-Hormonal Treatment Options for Menopausal Symptoms
  70. NonHormonal Treatments for Menopausal Symptoms
  71. Office of Dietary Supplements: Calcium
  72. Office of Dietary Supplements: Vitamin D
  73. Oestrogen Only Menopausal Hormone Therapy
  74. Osteoporosis Explained – A British Menopause Society Video
  75. Practical Prescribing Explained – A British Menopause Society Video
  76. Psychosocial Stress and Bone Loss Among Postmenopausal Women: Results From the Women’s Health Initiative
  77. Revised Global Consensus Statement on Menopausal Hormone Therapy
  78. Risks and Benefits of MHT/HRT
  79. Sorry Folks, We Were Wrong At the Time
  80. The Evidence Base for HRT: What Can We Believe?
  81. The Women’s Health Initiative
  82. The Women’s Health Initiative Study and Hormone Therapy – What Have We Learned 10 Years On?
  83. Tibolone As Menopausal Hormone Therapy
  84. Tipos de Hormonoterapia
  85. Types of Hormone Therapy
  86. Urogenital Atrophy Explained – A British Menopause Society Video
  87. Urogenital Problems
  88. Vaginal Dryness
  89. Video Series-2018 – Risks and Benefits of Long Term Hormone Therapy
  90. Video Series-2018 – Tailoring Estrogen Therapy for Maximum Cardiovascular Health
  91. Video Series-2019 – Hormone Therapy–What Are We Doing In 2019?
  92. Video Series-2019 – What Is New In Hormone Therapy?
  93. Video Series-2020 – Bone Health What You Need To Know
  94. Video Series-2020 – What Women Need To Know About Heart Disease
  95. Women’s Health Initiative WHI Randomised Study Long Term Follow Up Results – December 2019: HRT and Breast Cancer
  96. What Is Menopausal Hormone Therapy (MHT) and Is It Safe?
  97. Women’s Health Initiative
  98. Women’s Health Initiative (WHI)
  99. Women’s Health Initiative Reaffirms Use of Short-Term Hormone Replacement Therapy for Younger Women
  100. Women’s Wellness: Treating Hot Flashes and Night Sweats Without Hormones [+ Video]

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. About WHI. Women’s Health Initiative https://www.whi.org/about/SitePages/About%20WHI.aspx Accessed: 03 May 2020
  2. About WHI. Women’s Health Initiative https://www.whi.org/about/SitePages/About%20WHI.aspx Accessed: 03 May 2020
  3. Women’s Health Initiative (WHI): What Is the Goal of the WHI? National Heart, Lung, and Blood Institute https://www.nhlbi.nih.gov/science/womens-health-initiative-whi Accessed: 03 May 2020
  4. About WHI. Women’s Health Initiative https://www.whi.org/about/SitePages/About%20WHI.aspx Accessed: 03 May 2020
  5. NAMS Journal Menopause Reflects on the WHI Ten Years Later. 29 May 2012:1. North American Menopause Society https://www.menopause.org/docs/default-document-library/pr12whi.pdf?sfvrsn=2 Accessed: 03 May 2020
  6. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section A: Benefit/Risk Profile of MHT. Climacteric, 2016;19:4:313 https://www.imsociety.org/manage/images/pdf/ba6379e868044bec13015ac2b84f2753.pdf Accessed: 03 May 2020
Topic Last Updated: 03 May 2020 – Topic Last Reviewed: 03 May 2020
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