Hormone Therapy and Ovarian Cancer

Hormone Therapy and Ovarian Cancer

“Deciding to use MHT is a personal choice and should
involve discussions about the benefits and risks with
a healthcare professional who knows your health history”.1

Umbrella

What may the Hormone Therapy and Ovarian Cancer Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Cancer of the Ovary
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Replacement Therapy (MHT)
  • Ovarian Cancer

Ovarian Cancer Risk

Does hormone therapy (HT) increase the risk of ovarian cancer?

In Symptoms & Risks: What Are the Risk Factors for Ovarian Cancer? the World Ovarian Cancer Coalition explain:

“Hormone Replacement –
Your risk may be higher if you have taken hormone replacement”.2

Ovarian Cancer

Combined HRT

Does combined hormone replacement therapy (HRT) increase the risk of ovarian cancer?

In Menopausal Hormone Replacement Therapy and Cancer Risk: Types of Hormone Treatments for Menopause and Their Risks – Estrogen-Progestin Therapy (EPT) and Cancer Risk: Ovarian Cancer, last revised 22 January 2026 the American Cancer Society (ACS) note:

“EPT is linked to a small increase in ovarian cancer risk, especially while it is being taken. Overall, the risk remains low and drops after EPT is stopped”.3

Oestrogen-Only HRT

Does oestrogen-only HRT increase the risk of ovarian cancer?

In Menopausal Hormone Replacement Therapy and Cancer Risk: Types of Hormone Treatments for Menopause and Their Risks – Estrogen Therapy and Cancer Risk: Ovarian Cancer  the ACS also note:

“EPT is linked to a small increase in ovarian cancer risk, especially while it is being taken. Overall, the risk remains low and drops after EPT is stopped”.4

Health Care Provider

If I choose to use hormone therapy (HT) what is my risk of ovarian cancer?

Different women who choose to use HT can have different risks of ovarian cancer. It may therefore be in your best interest to also choose to ask your health care provider about this.

On page one in Deciding About Hormone Therapy Use, published February 2025, the Menopause Society (formerly the North American Menopause Society) explain:

“Every woman is different, and you will decide about whether to use HT based on the severity of your symptoms, your personal and family health history, and your own beliefs about menopause treatments. Your healthcare professional will be able to help you with your decision”.5

Hormone Therapy and Ovarian Cancer On page three of Menopause and Menopause Hormone Therapy: 1. Who Is MHT For? Women With Existing Medical Conditions the International Menopause Society’s (IMS) Leaflet for Women for World Menopause Day 2024, the IMS include:

“Women with certain medical histories such as breast cancer and blood clots should talk to their healthcare professional about whether MHT is safe for them. Deciding to use MHT is a personal choice and should involve discussions about the benefits and risks with a healthcare professional who knows your health history”.6

Health Topics A-Z

Where may I find Health Topics A-Z related to Hormone Therapy and Ovarian Cancer?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

Where may I find Links related to Hormone Therapy and Ovarian Cancer?

Your Country may have Links similar to:

Links

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New or Updated

  1. ACOG Explains: Managing Menopause Symptoms [American College of Obstetricians and Gynecologists]
  2. ASCO: Conjugated Equine Estrogen May Increase Risk for Ovarian Cancer
  3. Askearlymenopause.org [Ask Early Menopause]
  4. Bioidentical Hormones: Are They Safer?
  5. Cognitive Behaviour Therapy (CBT) for Menopausal Symptoms
  6. Consumer Video and Podcast Series: 2024 Consumer Videos and Podcasts – Preparing for Your Menopause Health Care Visit
  7. Consumer Video and Podcast Series: 2025 Consumer Videos and Podcasts – Abnormal Uterine Bleeding—When To See A Clinician
  8. Deciding About Hormone Therapy
  9. Deciding About Hormone Therapy Use
  10. Does Hormone Replacement Therapy (HRT) Increase the Risk of Cancer?
  11. Does Hormone Replacement Therapy (HRT) Increase the Risk of Cancer? Does Combined HRT Increase the Risk of Cancer? Ovarian Cancer
  12. Does Hormone Replacement Therapy (HRT) Increase the Risk of Cancer? Does Oestrogen-Only HRT Increase the Risk of Cancer? Ovarian Cancer
  13. EMAS On-Demand Webinars [European Menopause and Andropause Society] [Multiply Languages]: FDA Decision on MHT Warnings – A Live EMAS Roundtable
  14. February Is Ovarian Cancer Awareness Month [Australia]
    Hormone Therapy and Ovarian Cancer
  15. Find A Member [Australasian Menopause Society i.e. Australia and New Zealand]
  16. Find A Menopause Practitioner [United States and Other]
  17. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  18. Foundationforwomenscancer.org [Foundation for Women’s Cancer, United States]
  19. HRT Questions Answered
  20. HRT and Ovarian Cancer: Is There A Link?
  21. HRT – Types, Doses and Regimens
  22. Handling Hot Flushes and Night Sweats| Dr Louise Newson
  23. ‘Healthy Menopause’: The European Menopause and Andropause Society (EMAS) 2026 Framework for Precision, Digital, and Interdisciplinary Midlife Health
  24. Hormone Replacement Therapy (HRT)
  25. Hormone Replacement Therapy (HRT): A Summary
  26. Hormone Replacement Therapy (HRT): Alternatives To Hormone Replacement Therapy (HRT)
  27. Hormone Replacement Therapy (HRT): Benefits and Risks
  28. Hormone Replacement Therapy (HRT): Types of Hormone Replacement Therapy (HRT)
  29. Hormone Therapy: Is It Right for You?
  30. Hot Flashes
  31. How To Find Relief for Hot Flashes At Night
  32. International Menopause Society (IMS) Recommendations and Key Messages on Women’s Midlife Health and Menopause
  33. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause
  34. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – Hormone Replacement Therapy (HRT) [+ Video: Is HRT Bad for You?] [Other Languages and Formats]
  35. Mayo Clinic Q&A: Get the Facts on Ovarian Cancer
  36. Menopausal Hormone Replacement Therapy and Cancer Risk
  37. Menopausal Hormone Therapy
  38. Menopausal Hormone Use and Ovarian Cancer Risk: Individual Participant Meta-Analysis of 52 Epidemiological Studies
  39. Menopause
  40. Menopausal Symptom Treatments
  41. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
    Hormone Therapy and Ovarian Cancer
  42. Menopause Treatment
  43. Menopause, Perimenopause, Hormone Therapy and Other Treatments With Madelyn Butler, MD [Podcast]
  44. Menopause: Identification and Management [NICE Guideline]
  45. Menopause: Identification and Management [NICE Guideline]
    Hormone Therapy
  46. Menopause: Menopause – Hormone Treatments
  47. Navigating Menopause: Honest Answers To All Your Questions [+ Video: What To Expect in Menopause]
  48. OCCAM Office of Cancer Complementary and Alternative Medicine [National Cancer Institute, United States]
  49. Online Events [International Menopause Society]: IMS Partnership Symposia Series – What’s Hot? Options for Treatment of Hot Flushes 2025
  50. Online Events [International Menopause Society]: Past Webinars – 2026: New IMS Recommendations – Midlife Body Changes
  51. Ovarian Cancer
  52. Ovarian Cancer
  53. Ovarian Cancer
    Hormone Therapy and Ovarian Cancer
  54. Ovarian Cancer
  55. Ovarian Cancer Risk Factors
  56. Ovarian Cancer Risk and Causes of Ovarian Cancer
  57. Ovarian Cancer/Primary Peritoneal
  58. Ovarian Cancer: Essential Facts You Need To Know – Mayo Clinic Health System [Video] [30 August 2024]
  59. Ovarian Cancer: Reducing Risk of Ovarian Cancer
  60. Risks and Causes
  61. Symptoms & Risks – What Are the Risk Factors for Ovarian Cancer?
    Ovarian Cancer
  62. Testing & Detection
    Hormone Therapy and Ovarian Cancer
  63. The Risk of Ovarian Cancer In Hormone Replacement Therapy Users: A Systematic Review and Meta-Analysis
  64. Tips for Tracking Your Bleeding
  65. Types of Hormone Therapy
  66. Use of Menopausal Hormone Therapy and Ovarian Cancer Risk In A French Cohort Study
  67. What Is Ovarian Cancer?
  68. World GO Day [World Gynecologic Oncology Day, 20 September]
    Hormone Therapy and Ovarian Cancer
  69. World Menopause Day 2024: Leaflet for Women – Menopause and Menopause Hormone Therapy [Multiply Languages]
  70. World Ovarian Cancer Day [08 May 2026]
    Hormone Therapy and Ovarian Cancer

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Menopause and Menopause Hormone Therapy: 1. Who Is MHT For? Women With Existing Medical Conditions. 2024:3. International Menopause Society https://www.imsociety.org/wp-content/uploads/2024/10/2024-WMD-Leaflet_English.pdf Accessed: 19 August 2026
  2. Symptoms & Risks: What Are the Risk Factors for Ovarian Cancer? World Ovarian Cancer Coalition https://worldovariancancercoalition.org/about-ovarian-cancer/symptoms-risk-factors/ovarian-cancer-symptoms/ Accessed: 19 August 2026
  3. Menopausal Hormone Replacement Therapy and Cancer Risk: Types of Hormone Treatments for Menopause and Their Risks – Estrogen-Progestin Therapy (EPT) and Cancer Risk: Ovarian Cancer. Last Revised: 22 January 2026. American Cancer Society https://www.cancer.org/cancer/risk-prevention/medical-treatments/menopausal-hormone-replacement-therapy-and-cancer-risk.html Accessed: 19 August 2026
  4. Menopausal Hormone Replacement Therapy and Cancer Risk: Types of Hormone Treatments for Menopause and Their Risks – Estrogen Therapy and Cancer Risk: Ovarian Cancer. Last Revised: 22 January 2026. American Cancer Society https://www.cancer.org/cancer/risk-prevention/medical-treatments/menopausal-hormone-replacement-therapy-and-cancer-risk.html Accessed: 19 August 2026
  5. Deciding About Hormone Therapy Use. 2025:1. Menopause Society https://menopause.org/wp-content/uploads/default-document-library/MenoNote-Deciding-About-HT-2025.pdf Accessed: 19 August 2026
  6. Menopause and Menopause Hormone Therapy: 1. Who Is MHT For? Women With Existing Medical Conditions. 2024:3. International Menopause Society https://www.imsociety.org/wp-content/uploads/2024/10/2024-WMD-Leaflet_English.pdf Accessed: 19 August 2026
Topic Last Updated: 19 August 2026 – Topic Last Reviewed: 19 August 2026

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