“Current or ever HRT use
is partly correlated with
the decreased incidence of lung cancer in women”.1

Umbrella
What may the Hormone Therapy and Lung Cancer Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Cancer of the Lung
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Lung Cancer
  • Menopausal Hormone Therapy (MHT)

Incidence

Is there an association between menopausal hormone therapy (MHT) and the incidence of lung cancer in women?

In The Association Between Different Hormone Replacement Therapy Use and the Incidence of Lung Cancer: A Systematic Review and Meta-Analysis, published 28 February 2022, the authors note:

Hormone Therapy and Lung CancerConclusions: Current or ever HRT use is partly correlated with the decreased incidence of lung cancer in women. Concerns about the incidence of lung cancer can be reduced when perimenopausal and postmenopausal women use current HRT to reduce menopausal symptoms. Meanwhile, given the roles of hormone receptors and relevant genes single nucleotide polymorphism (SNPs) among females, HRT use should be cautiously administered and individualized”.2

In The Influence of Hormone Replacement Therapy on Lung Cancer Incidence and Mortality, published 05 November 2019, the authors note:

Conclusions: These data represent among the largest prospective cohorts suggesting HRT use may have a protective effect on the development of NSCLC among women; the physiological basis of this effect merits further study; however, the results may influence discussion surrounding HRT use in women”.3

Health Care Provider

If I choose to use HT what is my risk of lung cancer?

Different women who choose to use HT can have different risks of lung cancer. It may therefore be in your best interest to also choose to talk to your health care provider about this

In The 2022 Hormone Therapy Position Statement of The North American Menopause Society, published July 2022, the North American Menopause Society elaborate on:

“Hormone therapy remains the most effective treatment for vasomotor symptoms (VMS) and the genitourinary syndrome of menopause and has been shown to prevent bone loss and fracture. The risks of hormone therapy differ depending on type, dose, duration of use, route of administration, timing of initiation, and whether a progestogen is used. Treatment should be individualized using the best available evidence to maximize benefits and minimize risks, with periodic reevaluation of the benefits and risks of continuing therapy”.4

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Sources

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Sources

  1. Wen, H., Lin, X., Dun, D. The Association Between Different Hormone Replacement Therapy Use and the Incidence of Lung Cancer: A Systematic Review and Meta-Analysis: Conclusions. 28 February 2022 https://jtd.amegroups.com/article/view/61565/html Accessed: 20 February 2023
  2. Wen, H., Lin, X., Dun, D. The Association Between Different Hormone Replacement Therapy Use and the Incidence of Lung Cancer: A Systematic Review and Meta-Analysis: Conclusions. 28 February 2022 https://jtd.amegroups.com/article/view/61565/html Accessed: 20 February 2023
  3. Titan, A. L., He, H. Lui, N., Liou, D., Berry, M., Shrager, J. B., Backhus, L. M. The Influence of Hormone Replacement Therapy on Lung Cancer Incidence and Mortality: Conclusions. 05 November 2019https://www.jtcvs.org/article/S0022-5223(19)32348-7/fulltext Accessed: 20 February 2023
  4. The 2022 Hormone Therapy Position Statement of The North American Menopause Society. July 2022. North American Menopause Society https://journals.lww.com/menopausejournal/Abstract/2022/07000/The_2022_hormone_therapy_position_statement_of_The.4.aspx Accessed: 20 February 2023

Topic Last Updated: 02 March 2023 – Topic Last Reviewed: 20 February 2023
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