Hormone Therapy and Osteoporosis

“…HRT has been shown to have an effective role
in the prevention and treatment of osteoporosis.
Bisphosphonates are considered as first-line options…”.1

Umbrella
What may the Hormone Therapy and Osteoporosis Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Osteoporosis
  • Postmenopause Osteoporosis
  • Thin Bones

Bone Loss Prevention

Is hormone therapy (HT) approved for prevention of bone loss?

On page 775 in The 2022 Hormone Therapy Position Statement of The North American Menopause Society: Osteoporosis – Key Points, published July 2022 and “endorsed by more than 20 well-respected international organizations”, the North American Menopause Society (NAMS) note:

  • “Hormone therapy is FDA approved for prevention of bone loss, but not for treatment of osteoporosis. (Level I)”.2

What is FDA?

FDA can be an abbreviation for the (United States) Food and Drug Administration.

What is Level I?

In this context “Level I: Based on good and consistent scientific evidence”.

Early Menopause

What is one of the highlights about early menopause included in the 2022 Hormone Therapy Position Statement of the North American Menopause Society?

On page one in The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement, published 07 July 2022, one of the highlights is:

  • “Women with primary ovarian insufficiency and premature or early menopause have higher risks of bone loss, heart disease, and cognitive or affective disorders associated with estrogen deficiency. It is recommended that hormone therapy can be used until at least the mean age of menopause unless there is a contraindication to its use”.3

Early Menopause and Breast Cancer Risk

What is one of the recommendations included in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause?

On page two in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause, first published online 10 June 2022, one of the recommendations is:

  • “Women with POI and early menopause (40–45 years old) should be advised that HRT is unlikely to increase risk of breast cancer in younger menopausal women under the age of 50”.4

Postmenopausal Bone Loss

Does HT prevent bone loss in healthy postmenopausal women?

On page 775 in The 2022 Hormone Therapy Position Statement of The North American Menopause Society: Osteoporosis – Key Points the NAMS include:

  • “Hormone therapy prevents bone loss in healthy postmenopausal women, with dose-related effects on bone density. (Level I)”.5

Postmenopausal Fracture Risk

Does HT reduce fracture risk in healthy postmenopausal women?

On page 775 in The 2022 Hormone Therapy Position Statement of The North American Menopause Society: Osteoporosis – Key Points the NAMS include:

  • “Hormone therapy reduces fracture risk in healthy postmenopausal women. (Level I)”.6

Postmenopausal Osteoporosis

Can HT be used in the prevention of osteoporosis?

On page two in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause, first published online 10 June 2022, one of the recommendations is:

Hormone Therapy and Osteoporosis

  • “Bisphosphonates are considered as first-line options for most patients with postmenopausal osteoporosis due to their broad spectrum of anti-fracture efficacy”.7

Bisphosphonates

What are bisphosphonates?

DotS the definition of bisphosphonates may vary. In Bisphosphonates: What Are Biphosphenates? Drugs.com elaborate on:

“Bisphosphonates are a group of medicines that slow down or prevent bone loss, strengthening bones. Bisphosphonates inhibit osteoclasts which are responsible for breaking down and reabsorbing minerals such as calcium from bone (the process is known as bone resorption). Bisphosphonates allow osteoblasts (bone building cells) to work more effectively, improving bone mass”.8

Health Care Provider

What if I choose to use HT?

If you choose to use HT it may be in your best interest to also choose to talk to your health care provider about this.

On page two in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause, first published online 10 June 2022, one of the recommendations is:

  • “The decision whether to take HRT, the dose and duration of its use should be made on an individualised basis after discussing the benefits and risks with each patient. This should be considered in the context of the overall benefits obtained from using HRT including symptom control and improving quality of life as well as considering the bone and cardiovascular benefits associated with HRT use”.9

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy and Osteoporosis?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

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Links

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New or Updated

  1. Ask Early Menopause.org
  2. BMS & WHC’s 2020 Recommendations on Hormone Replacement Therapy In Menopausal Women
  3. Bioidentical Hormones
  4. Bioidentical Hormones Explained – A British Menopause Society Video
  5. Bisphosphonates
  6. Combined Menopausal Hormone Therapy (MHT)
  7. Compounded Bioidentical Hormone Therapy [Video]
  8. Deciding About Hormone Therapy
  9. Deciding About Hormone Therapy Use
  10. Dr Gail Busby – I Forgot To Ask the Doctor – Episode 9 The Menopause
  11. HRT
  12. HRT & Menopause Extra
  13. HRT and Alternatives
  14. HRT – Types, Doses and Regimens
  15. HRT: Benefits and Risks
  16. Health After Menopause
  17. Hormone Replacement Therapy (HRT)
  18. Hormone Replacement Therapy (HRT) Explained – A British Menopause Society Video
  19. Hormone Replacement Therapy (HRT) With Dr Nicky Peel & Prof. David Armstrong
  20. Hormone Replacement Therapy (HRT): Types
  21. Hormone Therapy In Postmenopausal Persons: Primary Prevention of Chronic Conditions
  22. Hormone Therapy: Is It Right for You?
  23. Index To Drug-Specific Information [United States]
  24. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause
  25. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health
  26. Maintaining Health and Preventing Disease After the Menopause
  27. Making Choices At Menopause
  28. Making Sense of Menopausal Hormone Therapy Means Understanding the Benefits As Well As the Risks
  29. Managing Menopause: Don’t Let Symptoms of Menopause Reduce Your Quality of Life
  30. Menopausal Hormone Therapy
  31. Menopausal Hormone Therapy and Breast Cancer Risk
  32. Menopause
  33. Menopause
  34. Menopause
  35. Menopause & Herbs
  36. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  37. Menopause FAQs: Your Health After Menopause
  38. Menopause Management Options: Menopausal Hormone Therapy (MHT)
  39. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
  40. Menopause Patient Information [Videos] 2. Talking To Your GP About Menopause
  41. Menopause Patient Information [Videos] 3. The Risks & Benefits of HRT
  42. Menopause Patient Information [Videos] 4. The Different Types of HRT
  43. Menopause Patient Information [Videos] 5. Lifestyle Advice In Menopause & Perimenopause
  44. Menopause Preparedness Toolkit Video Series: Common Conditions Associated With Menopause and Midlife
  45. Menopause Preparedness Toolkit Video Series: Lifestyle Tips for Menopause
  46. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  47. Menopause Treatments: What Works, What Doesn’t
  48. Menopause: Diagnosis & Treatment
  49. Menopause: Diagnosis and Management – Information for the Public: Benefits and Risks of HRT [NICE Guideline]
  50. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  51. Menopause: Symptoms & Causes
  52. National Center for Complementary and Integrative Health: Menopausal Symptoms: In Depth
  53. National Center for Complementary and Integrative Health: Natural Doesn’t Necessarily Mean Safer, or Better
  54. National Osteoporosis Month [May, United States]
  55. Navigating Menopause: Expert Insights and Solutions | Dr Susan Davis | The Proof Podcast EP 245
  56. Oestrogen Only Menopausal Hormone Therapy
  57. Osteoporosis
  58. Osteoporosis
  59. Osteoporosis
  60. Osteoporosis Explained – A British Menopause Society Video
  61. Osteoporosis Treatment: A-Z of Osteoporosis Treatments
  62. Osteoporosis Treatment: Medications Can Help
  63. Osteoporosis: Bone Health Following Menopause
  64. Postmenopause
  65. Recipes: Bone Healthy Recipes [United States National Osteoporosis Foundation]
  66. Risks and Benefits of MHT
  67. Screening for Osteoporosis
  68. The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement
  69. Tips To Help Manage Menopause Symptoms
  70. Treatment
  71. Treatment
  72. Video Series-2022: Hormone Therapy: Understanding the Risks and Benefits
  73. Video Series-2023
  74. Videos and Podcasts: Videos – Interviews: Bone Health
  75. Videos and Podcasts: Videos – Interviews: Bone Health What Why and How
  76. Videos and Podcasts: Videos – Interviews: Prevention of Chronic Diseases In Women: Where Does MHT Fit In?
  77. Videos and Podcasts: Videos – Interviews: The Women’s Health Initiative – What Can We Believe?
  78. Webinars: Previous – Osteoporosis for Midlife Women and Beyond
  79. Webinars: Previous – Update on Bone Health
  80. What Are the Benefits and Risks of HRT?
  81. Why Didn’t Anyone Tell Me This? Episode 3: Dr Annice Mukherjee: Your Essential Menopause Toolkit
  82. World Menopause Day
    Hormone Therapy and Osteoporosis
  83. World Menopause Day: Patient Information Leaflet – Update on Bone Health [Multiply Languages]
    Hormone Therapy and Osteoporosis
  84. Worldosteoporosisday.org [World Osteoporosis Day]

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 10 June 2022:2. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 27 March 2023
  2. The 2022 Hormone Therapy Position Statement of The North American Menopause Society: Osteoporosis – Key Points. July 2022: 775. North American Menopause Society https://www.menopause.org/docs/default-source/professional/nams-2022-hormone-therapy-position-statement.pdf Accessed: 27 March 2023
  3. The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement. 07 July 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/press-release/ht-position-statement-release.pdf Accessed: 27 March 2023
  4. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 10 June 2022:2. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 27 March 2023
  5. The 2022 Hormone Therapy Position Statement of The North American Menopause Society: Osteoporosis – Key Points. July 2022: 775. North American Menopause Society https://www.menopause.org/docs/default-source/professional/nams-2022-hormone-therapy-position-statement.pdf Accessed: 27 March 2023
  6. The 2022 Hormone Therapy Position Statement of The North American Menopause Society: Osteoporosis – Key Points. July 2022: 775. North American Menopause Society https://www.menopause.org/docs/default-source/professional/nams-2022-hormone-therapy-position-statement.pdf Accessed: 27 March 2023
  7. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 10 June 2022:2. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 27 March 2023
  8. Bisphosphonates: What Are Bisphosphonates? Drugs.com https://www.drugs.com/drug-class/bisphosphonates.html Accessed: 27 March 2023
  9. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayasena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 10 June 2022:2. https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 27 March 2023
Topic Last Updated: 27 March 2023 – Topic Last Reviewed: 27 March 2023

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