Hormone Therapy and SERMs

Hormone Therapy and SERMs

“SERMs is “shorthand” for a class of drug called
selective oestrogen receptor modulators.
They are a versatile group of drugs that can be used to…”.1

Umbrella

What may the Hormone Therapy and SERMs Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Bazedoxifene (BZA)
  • Evista (chemical name: Raloxifene (RLX))
  • Fareston (chemical name: Toremifene)
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Nolvadex
  • Oestrogen Agonist/Antagonists
  • Ospemifene
  • Selective Estrogen Receptor Modulators (SERMs)
  • Soltamox
  • Tamoxifen (TAM) (brand name: Soltamox)

SERMs

What are SERMs?

In SERMs – Their Role In Menopause Management, content updated May 2023, the Australasian Menopause Society (AMS) explain:

“SERMs is “shorthand” for a class of drug called selective oestrogen receptor modulators”.2

In Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? the (United States) Cleveland Clinic note:

“Selective estrogen receptor modulators (SERMs) are hormone therapies that manage how estrogen works in your body. SERMs such as tamoxifen (Nolvadex®, Soltamox®) and Raloxifene (Evista®) are effective treatments for some types of breast cancer and osteoporosis”.3

Different Kinds of SERMs

What are different kinds of SERMs?

In SERMs – Their Role In Menopause Management: Different Kinds of SERMs the AMS include:

  • “Tamoxifen…
  • Raloxifene…
  • Bazedoxifene…
  • Ospemifene…
  • Lasofoxifene…”.4

Treatment

What can SERMs be used to treat?

In SERMs – Their Role In Menopause Management the AMS elaborate on:

“They are a versatile group of drugs that can be used to treat/ prevent several conditions such as osteoporosis, infertility and hormone responsive cancers. Within the SERM class, different compounds have differing agonist or antagonist effects at the oestrogen receptor in different tissues, therefore they are “selective””.5

In Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? How Do SERMs Work? the Cleveland Clinic note:

“SERMs are medical multitaskers. They block estrogen from connecting with breast cancer cells, keeping the cells from multiplying. At the same time, SERMs act like estrogen, boosting estrogen levels in your bones and preventing osteoporosis”.6

Health Care Provider

What if I choose to use SERMs?

If you choose to use SERMs, it may be in your best interest to also choose to talk to your health care provider about this.

In Selective Estrogen Receptor Modulators (SERMs) the (United States) Breastcancer.org note:

Hormone Therapy and SERMs“If you’re having problematic side effects from taking a SERM, tell your doctor right away. You may be able to take a different dose or try a different hormonal therapy medicine”.7

Health Topics A-Z

Where may I find Health Topics A-Z related to Hormone Therapy and SERMs?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

Where may I find Links related to Hormone Therapy and SERMs?

Your Country may have Links similar to:

Links

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New or Updated

  1. ACOG Explains: Managing Menopause Symptoms [American College of Obstetricians and Gynecologists]
  2. Bioidentical Hormones: Are They Safer?
  3. Bone Health, Hormones and the Real Risk of Osteoporosis
  4. Bonetalk.org [Bone Talk, United States]
    Hormone Therapy and SERMs
  5. Breastcancer.now [United Kingdom]
  6. Breastcancer.org [United States]
  7. Build Better Bones.org [International Osteoporosis Foundation]
    Hormone Therapy and SERMs
  8. Can Selective Estrogen Receptor Modulators (SERMs) Be Used For Osteoporosis?
  9. Consumer Video and Podcast Series: 2023 Consumer Videos and Podcasts – Lifestyle Modification and Prevention of Breast Cancer
  10. Consumer Video and Podcast Series: 2024 Consumer Videos and Podcasts – Preparing for Your Menopause Health Care Visit
  11. Deciding About Hormone Therapy Use
  12. Evista
  13. Fareston
  14. HRT
  15. HRT Questions Answered
  16. HRT – Types, Doses and Regimens
  17. HRT: Benefits and Risks
  18. Hormonal Therapy for Breast Cancer
  19. Hormone Replacement Therapy (HRT)
  20. Hormone Replacement Therapy (HRT): Benefits and Risks of Hormone Replacement Therapy (HRT)
  21. Hormone Therapy: Is It Right for You?
  22. Hormone (Endocrine Therapy)
  23. Hormones & Osteoporosis: The Hidden Risk for Women In Menopause | Dr Louise Newson
  24. Hot Flashes: What Can I Do? [+ Video: What Are the Signs and Symptoms of Menopause?]
  25. How Menopause Impacts Your Health
  26. International Menopause Society (IMS) Recommendations and Key Messages on Women’s Midlife Health and Menopause
  27. Is There Still A Role for SERMs In Menopause Management?
  28. May Is Osteoporosis Awareness and Prevention Month!
    Hormone Therapy and SERMs
  29. Menopause
  30. Menopause
  31. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
  32. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  33. Menopause Treatments: What Works, What Doesn’t
  34. Menopause: Identification and Management [NICE Guideline Published: 12 November 2015 Last Updated: 07 November 2024]
  35. Menopause: Identification and Management: NICE Guideline [NG23] [07 November 2024]
  36. National Center for Complementary and Integrative Health: Know the Science: How Medications and Supplements Can Interact
  37. National Women’s Health Week [11-17 May 2025]: Navigating the Road to Menopause
    Hormone Therapy and SERMS
  38. Nonhormone Treatments for Hot Flashes and Night Sweats
  39. Pathtogoodbonehealth.org [Your Path To Good Bone Health, Bone Health & Osteoporosis Foundation, United States]
    Hormone Therapy and SERMS
  40. Raloxifene (Oral Route)
  41. Risks and Benefits of MHT
  42. SERMS: Menopause and Healthy Aging
  43. SERMs – Their Role In Menopause Management
  44. Selective Estrogen Receptor Modulators (SERMs)
  45. Selective Estrogen Receptor Modulators (SERMs)
  46. Tamoxifen
  47. The Menopause Society Statement on Misinformation Surrounding Hormone Therapy
  48. Treatments for Menopause
  49. Updated 2024 NICE Menopause Guidance Summary
  50. Videos & Podcasts: Videos – Menopause and Hormone Therapy: Current Perspectives and Controversies
  51. Videos & Podcasts: Videos – Preventing Bone Loss At Menopause
  52. Videos and Podcasts: Videos – A Simple Approach To Menopause: The Menopause Quick Six (www.MQ6.ca)
  53. Webinars: Approach To Bone Health In the Perimenopause and Postmenopause?
  54. Webinars: Changing the Paradigm for Earlier Osteoporosis Prevention
  55. What Is Osteoporosis and What Causes It? [+ Video: What Is Osteoporosis]
  56. What Is Osteoporosis?
  57. What Is Raloxifene And What Are Its Benefits As A SERM? – Oncology Support Network
  58. World Menopause Day 2024: Leaflet for Women – Menopause and Menopause Hormone Therapy [Multiply Languages]
  59. World Menopause Day 2024: Poster for Women – The 5 Ws of Menopause Hormone Therapy (MHT)

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. SERMs – Their Role In Menopause Management. Content Updated: 16 May 2023. Australasian Menopause Society https://hub.menopause.org.au/Play?pId=529c7734-ab8c-4b1b-be0d-16d4f26460eb Accessed: 27 January 2026
  2. SERMs – Their Role In Menopause Management. Content Updated: 16 May 2023. Australasian Menopause Society https://hub.menopause.org.au/Play?pId=529c7734-ab8c-4b1b-be0d-16d4f26460eb Accessed: 27 January 2026
  3. Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? Last Reviewed: 03 February 2023. Cleveland Clinic https://my.clevelandclinic.org/health/treatments/24732-selective-estrogen-receptor-modulators-serm Accessed: 27 January 2026
  4. SERMs – Their Role In Menopause Management: Different Kinds of SERMs. Content Updated: 16  May 2023. Australasian Menopause Society https://hub.menopause.org.au/Play?pId=529c7734-ab8c-4b1b-be0d-16d4f26460eb Accessed: 27 January 2026
  5. SERMs – Their Role In Menopause Management. Content Updated: 16 May 2023. Australasian Menopause Society https://hub.menopause.org.au/Play?pId=529c7734-ab8c-4b1b-be0d-16d4f26460eb Accessed: 27 January 2026
  6. Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? How Do SERMs Work? Last Reviewed: 03 February 2023. Cleveland Clinic https://my.clevelandclinic.org/health/treatments/24732-selective-estrogen-receptor-modulators-serm Accessed: 27 January 2026
  7. Selective Estrogen Receptor Modulators (SERMs). Last Updated: 22 February 2023. Breastcancer.org https://www.breastcancer.org/treatment/hormonal-therapy/serms Accessed: 27 January 2026
Topic Last Updated: 27 January 2026 – Topic Last Reviewed: 27 January 2026

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