Hormone Therapy and SERMs

Hormone Therapy and SERMs

“Selective estrogen receptor modulators (SERMs) are
hormone therapies that manage how estrogen works
in your body. SERMs such as tamoxifen (Nolvadex®…”.1

Umbrella

What may the Hormone Therapy and SERMs Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Bazedoxifene (BZA)
  • Evista (chemical name: Raloxifene (RLX))
  • Fareston (chemical name: Toremifene)
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Nolvadex
  • Oestrogen Agonist/Antagonists
  • Ospemifene
  • Selective Estrogen Receptor Modulators (SERMs)
  • Soltamox
  • Tamoxifen (TAM) (brand name: Soltamox)

SERMs

What are SERMs?

In Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? the (United States) Cleveland Clinic note:

“Selective estrogen receptor modulators (SERMs) are hormone therapies that manage how estrogen works in your body. SERMs such as tamoxifen (Nolvadex®, Soltamox®) and Raloxifene (Evista®) are effective treatments for some types of breast cancer and osteoporosis”.2

Treatment

What can SERMs treat?

In Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? How Do SERMs Work? the Cleveland Clinic note:

“SERMs are medical multitaskers. They block estrogen from connecting with breast cancer cells, keeping the cells from multiplying. At the same time, SERMs act like estrogen, boosting estrogen levels in your bones and preventing osteoporosis”.3

Health Care Provider

What if I choose to use SERMs?

The Cleveland Clinic explains:

Hormone Therapy and SERMs“If you’re at risk for breast cancer or you have osteoporosis, ask a healthcare provider to explain SERM benefits and risk factors. They’ll be glad to help you understand how selective estrogen receptor modulators work and if this treatment is appropriate given your situation”.4 

Health Topics A-Z

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In Health Topics A-Z you may find:

Health Topics A-Z

Links

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New or Updated

  1. ACOG Explains: Managing Menopause Symptoms [American College of Obstetricians and Gynecologists]
  2. Bioidentical Hormones: Are They Safer?
  3. Bone Health, Hormones and the Real Risk of Osteoporosis
  4. Bonetalk.org [Bone Talk, United States]
    Hormone Therapy and SERMs
  5. Breastcancer.now [United Kingdom]
  6. Breastcancer.org [United States]
  7. Build Better Bones.org [International Osteoporosis Foundation]
    Hormone Therapy and SERMs
  8. Consumer Video and Podcast Series: 2024 Consumer Videos and Podcasts – Preparing for Your Menopause Health Care Visit
  9. Deciding About Hormone Therapy Use
  10. Evista
  11. Fareston
  12. Finding the Right Hormone Treatments (HRT): Types, Doses and What Works
  13. HRT Questions Answered
  14. HRT – Types, Doses and Regimens
  15. Hormonal Therapy for Breast Cancer
  16. Hormone Replacement Therapy (HRT)
  17. Hormone Replacement Therapy (HRT): A Summary
  18. Hormone Replacement Therapy (HRT): Benefits and Risks
  19. Hormone Therapy: Is It Right for You?
  20. Hormone (Endocrine Therapy)
  21. Hormones & Osteoporosis: The Hidden Risk for Women In Menopause | Dr Louise Newson
  22. International Menopause Society (IMS) Recommendations and Key Messages on Women’s Midlife Health and Menopause
  23. May Is Osteoporosis Awareness and Prevention Month!
    Hormone Therapy and SERMs
  24. Menopausal Symptom Treatments
  25. Menopause
  26. Menopause
  27. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
    Hormone Therapy and SERMs
  28. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  29. Menopause: Identification and Management [NICE Guideline]
  30. Menopause: Identification and Management [NICE Guideline]
  31. National Center for Complementary and Integrative Health: Know the Science: How Medications and Supplements Can Interact
  32. Nonhormone Treatments for Hot Flashes and Night Sweats
  33. Online Events [International Menopause Society]: Past Webinars – 2024: Approach To Bone Health In the Perimenopause and Postmenopause?
  34. Online Events [International Menopause Society]: Past Webinars – 2025: Changing the Paradigm for Earlier Osteoporosis Prevention
  35. Online Events [International Menopause Society]: Past Webinars – 2026: New IMS Recommendations – Midlife Body Changes
  36. Osteoporosis & Oestrogen
  37. Pathtogoodbonehealth.org [Your Path To Good Bone Health, Bone Health & Osteoporosis Foundation, United States]
    Hormone Therapy and SERMs
  38. Raloxifene (Oral Route)
  39. SERMS: Menopause and Healthy Aging
  40. Selective Estrogen Receptor Modulators (SERMs)
  41. Selective Estrogen Receptor Modulators (SERMs)
  42. Tamoxifen
  43. Videos & Podcasts: Videos – Menopause and Hormone Therapy: Current Perspectives and Controversies
  44. Videos & Podcasts: Videos – Preventing Bone Loss At Menopause
  45. What Is Osteoporosis and What Causes It? [+ Video: What Is Osteoporosis?]
  46. What Is Osteoporosis?
  47. World Menopause Day 2024: Leaflet for Women – Menopause and Menopause Hormone Therapy [Multiply Languages] Hormone Therapy and SERMs

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? Last Updated: 03 February 2023. Cleveland Clinic https://my.clevelandclinic.org/health/treatments/24732-selective-estrogen-receptor-modulators-serm Accessed: 15 July 2026
  2. Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? Last Updated: 03 February 2023. Cleveland Clinic https://my.clevelandclinic.org/health/treatments/24732-selective-estrogen-receptor-modulators-serm Accessed: 15 July 2026
  3. Selective Estrogen Receptor Modulators (SERMs): Overview – What Are Selective Estrogen Receptor Modulators (SERMs)? How Do SERMs Work? Last Updated: 03 February 2023. Cleveland Clinic https://my.clevelandclinic.org/health/treatments/24732-selective-estrogen-receptor-modulators-serm Accessed: 15 July 2026
  4. Selective Estrogen Receptor Modulators (SERMs): Additional Details – A Note from Cleveland Clinic. Last Updated: 03 February 2023. Cleveland Clinic https://my.clevelandclinic.org/health/treatments/24732-selective-estrogen-receptor-modulators-serm Accessed: 15 July 2026
Topic Last Updated: 15 July 2026 – Topic Last Reviewed: 15 July 2026

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