Hormone Therapy and Dementia

“Hormonal status can affect cognitive function
and over the years there has been conflicting evidence
regarding the risk of dementia and HRT use”.1

Umbrella
What may the Hormone Therapy and Dementia Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone (Replacement) Therapy H(R)T
  • Hormone Medicines
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Hormones
  • Medicines for Hormone Replacement Therapy
  • Menopausal Hormone Therapy (MHT)
  • Menopause Hormone Medicines
  • Menopause Medicines

Date

What can it be important to be clear about with hormone therapy (HT) information?

It can be important to be clear about the date of all information including the date of HT information, because this information may have been updated.

Symptoms or Chronic Conditions

What can it also be important to be clear about with HT information?

It can also be important to be clear about whether HT information is about the use of HT for the management of menopausal symptoms such as hot flushes, night sweats and vaginal dryness or for the prevention of chronic conditions such as dementia, cardiovascular disease, cancer and osteoporosis.

Menopausal Hormone Therapy and Dementia Study, 28 June 2023

What is the Conclusions of the Menopausal Hormone Therapy and Dementia: Nationwide, Nested Case-Control Study, published 28 June 2023?

The Conclusions of the Menopausal Hormone Therapy and Dementia: Nationwide, Nested Case-Control Study is:

“Conclusions Menopausal hormone therapy was positively associated with development of all cause dementia and Alzheimer’s disease, even in women who received treatment at the age of 55 years or younger. The increased rate of dementia was similar between continuous and cyclic treatment. Further studies are warranted to determine whether these findings represent an actual effect of menopausal hormone therapy on dementia risk, or whether they reflect an underlying predisposition in women in need of these treatments”.2

In Menopausal Hormone Therapy and Dementia [Editorials], published 28 June 2023, in response to the above study Menopausal Hormone Therapy and Dementia: Nationwide, Nested Case-Control Study, what do the authors note:

In Menopausal Hormone Therapy and Dementia [Editorials], the authors note:

“Pourhadi and colleagues’ new study reported an association with increased risk of dementia even in women using menopausal hormone therapy before the age of 55 years for less than or equal to five years, which is within the age range recommended by the North American Menopause Society. Their findings contradict those of the WHIMS-Y trial and other trials that reported no effect on cognitive function among women who were randomly assigned to hormone therapy in early menopause. Although, longer follow-up is needed to determine participants’ dementia risk later in life”.3

Where may I find Links related to the Menopausal Hormone Therapy and Dementia: Nationwide, Nested Case-Control Study, published 28 June 2023?

Your Country may have Links similar to:

Links

This Links List to third party websites is neither comprehensive nor exhaustive. Inclusion on this Links List does not imply endorsement or recommendation. Non-inclusion on this Links List does not imply non-endorsement or non-recommendation. Third party websites are not under the control of Meno Martha International Menopause Directory. Third party websites may contain explicit medical images and/or sexual references. Please read Meno Martha International Menopause Directory’s Links Policy before proceeding to a Link. Please contact Webmaster if you experience a problem with a Link.

Dementia Risk Under the Age of 60 Years

Under the age of 60 years, can starting hormone therapy (HT) increase the risk of dementia?

On page two in HRT Benefits and Risks, published November 2020, the (British) Women’s Health Concern note:

“Hormonal status can affect cognitive function and over the years there has been conflicting evidence regarding the risk of dementia and HRT use. Based on the current evidence, women can be reassured that HRT is unlikely to increase the risk of dementia or be detrimental to cognitive function in women initiating HRT under the age of 60 years”.4

Dementia Risk Older than 65 Years

Older than 65 years, can starting HT increase the risk of dementia?

On page one in Deciding About Hormone Therapy Use: Potential Risks, published July 2022, the North American Menopause Society (NAMS) note:

“If started in women aged older than 65 years, HT might increase the risk of dementia”.5

Reducing Dementia Risk With HT

Is HT recommended to reduce the risk of dementia in women experiencing the menopause?

No. On page three in the Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause, first published online 10 June 2022, one of the recommendations is:

Hormone Therapy and Dementia

  • “Women should be reassured that HRT is unlikely to increase the risk of dementia or to have a detrimental effect on cognitive function in women initiating HRT before the age of 65. However, HRT should not be initiated for the purpose of reducing the risk of dementia in women experiencing the menopause. National as well as international recommendations do not support the use of HRT for the primary or secondary prevention of dementia”.6

In Hormones and Dementia: Does Hormone Replacement Therapy Reduce Dementia Risk? the (British) Alzheimer’s Society elaborate on:

“The research into whether taking oestrogen (as part of HRT) can reduce women’s risk of dementia has been mixed. Some studies suggest that oestrogen may reduce dementia risk whilst others say it increases it”.7

Documentary: Sex, Mind and the Menopause

What did the Channel 4 documentary Davina McCall: Sex, Mind and the Menopause discuss about HT and dementia?

In Menopause: HRT’s Brain-Protecting Effect May Be Overstated, published 11 May 2022, the authors note:

“The documentary, called Sex, Mind and the Menopause, discussed how the menopause can cause a range of brain-related symptoms, including brain fog, mood changes and memory problems. It also suggested that taking hormone replacement therapy (HRT) some years before the menopause may be the solution to these problems – alongside potentially halving a woman’s risk of developing dementia”.8

In Menopause: HRT’s Brain-Protecting Effect May Be Overstated the authors response to the Documentary also includes:

“Hormone replacement therapy can be effective for many women in alleviating a range of menopausal symptoms, particularly hot flushes. Whether HRT can prevent dementia or alleviate brain-related symptoms due to the menopause is still unclear. But fortunately, any brain changes that happen because of the menopause are usually temporary”.9

Health Care Provider

What if I would like to start HT?

If you would like to start HT, it may be in your best interest to also choose to talk to your health care provider about this.

On page one in Deciding About Hormone Therapy Use the NAMS elaborate on:

“Every woman is different, and you will decide about whether to use HT based on the severity of your symptoms, your personal and family health history, and your own beliefs about menopause treatments. Your healthcare professional will be able to help you with your decision”.10

Health Topics A-Z

Where may I find Health Topics A-Z related to Hormone Therapy and Dementia?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

Where may I find Links related to Hormone Therapy and Dementia?

Your Country may have Links similar to:

Links

This Links List to third party websites is neither comprehensive nor exhaustive. Inclusion on this Links List does not imply endorsement or recommendation. Non-inclusion on this Links List does not imply non-endorsement or non-recommendation. Third party websites are not under the control of Meno Martha International Menopause Directory. Third party websites may contain explicit medical images and/or sexual references. Please read Meno Martha International Menopause Directory’s Links Policy before proceeding to a Link. Please contact Webmaster if you experience a problem with a Link.

New or Updated

  1. 20 Years of Data Lead To Changes In Perceptions, Usage of Menopausal HT
  2. About Dementia: What Is Dementia?
  3. Askearlymenopause.org [Ask EM] [+ Video: What Is Early Menopause?]
  4. BMS TV: Bioidentical Hormones
  5. BMS TV: Hormone Replacement Therapy (HRT)
  6. Bioidentical Hormones: Are They Safer?
  7. Can Hormone Replacement Therapy Prevent Menopause Brain Changes?
  8. Deciding About Hormone Therapy
  9. Deciding About Hormone Therapy Use
  10. Dementia
  11. Dementia
  12. Dementia & MHT – Cause or Correlation?
  13. Does HRT Prevent Dementia? Or Cause It? Women’s Health Experts Prof Annice Mukherjee and Prof Joyce Harper Have Studied ALL the Research To Cut Through the Hype and Give the Definitive Answer
  14. Dr Louise Newson: The Truth About the Menopause & HRT
  15. Estrogen & Hormones: Estrogen and the Cardiovascular System
  16. Expert Reaction To Observational Study on HRT and Dementia
  17. Find A Menopause Practitioner [United States and Other]
  18. Find An AMS Doctor [Australasian Menopause Society i.e. Australia and New Zealand]
  19. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  20. HRT
  21. HRT Use By Younger Women Linked To Dementia, Study Says. Experts Disagree [CNN Report]
  22. HRT – Types, Doses and Regimens
  23. HRT: Benefits and Risks
  24. Hormone Replacement Therapy (HRT)
  25. Hormone Replacement Therapy (HRT): Benefits and Risks of Hormone Replacement Therapy (HRT)
  26. Hormone Therapy
  27. Hormone Therapy In Postmenopausal Persons: Primary Prevention of Chronic Conditions
  28. Hormone Therapy for Menopause
  29. Hormone Therapy for Menopause Linked To Increased Risk of Dementia
  30. Hormone Therapy for Menopause Symptoms
  31. Hormone Therapy: Is It Right for You?
  32. Hormone Therapy and Dementia: Novel Insights
  33. Hormones and Dementia
  34. Hot Flashes: What Can I Do? [+ Video: What Are the Signs and Symptoms of Menopause?]
  35. Hot Flashes? Night Sweats? Progesterone Can Help Reduce Symptoms of Menopause
  36. I Forgot To Ask the Doctor – E9: The Menopause: Can Every Woman That Wants It Have HRT?
  37. IMS Past President and Current Treasurer Quoted In CNN Health Article on HRT and Dementia Risk
  38. Is There A Link Between HRT and Cognitive Decline? Research Is Inconclusive
  39. Joint BMS, FSRH, RCGP and RCOG Position Statement on the Supply Shortages of Hormone Replacement Therapy (HRT)
  40. Joint Position Statement by the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause
  41. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – Hormone Replacement Therapy (HRT) [+ Video: Is HRT Bad for You?]
  42. Mayo Clinic Minute: Can the MIND Diet Improve Brain Health? [+ Video Courtesy: Mayo Clinic News Network]
  43. Mayo Clinic Minute: Help With Hot Flashes Due To Menopause [+ Video Courtesy: Mayo Clinic News Network]
  44. Mayo Clinic Q and A: Estrogen Replacement Therapy After Ovary Removal
  45. Menopausal Hormone Therapy
  46. Menopausal Hormone Therapy and Dementia [Editorials]
  47. Menopausal Hormone Therapy and Dementia: Nationwide, Nested Case-Control Study
  48. Menopausal Hormone Therapy and Women’s Health: An Umbrella Review
  49. Menopausal Hormone Therapy and the Mind: The Role of Hormone Replacement In the Prevention and Treatment of Cognitive Decline, Dementia, and Cognitive Dysfunction of Depression
  50. Menopause
  51. Menopause Hormone Therapy Significantly Alters Pathophysiological Biomarkers of Alzheimer’s Disease
  52. Menopause Management Options: Menopausal Hormone Therapy (MHT)
  53. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
    Hormone Therapy
  54. Menopause Patient Information [Videos] 2. Talking To Your GP About Menopause
  55. Menopause Patient Information [Videos] 3. The Risks & Benefits of HRT
  56. Menopause Patient Information [Videos] 4. The Different Types of HRT
  57. Menopause Preparedness Toolkit Video Series: Common Conditions Associated With Menopause and Midlife
  58. Menopause Preparedness Toolkit Video Series: Treating Vasomotor Symptoms of Menopause
  59. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  60. Menopause Treatment
  61. Menopause Treatments: What Works, What Doesn’t
  62. Menopause, Perimenopause, Hormone Therapy and Other Treatments With Madelyn Butler, MD [Podcast]
  63. Menopause: HRT’s Brain-Protecting Effect May Be Overstated
  64. Menopause: Things You Can Do
  65. Mitochondria, Estrogen and Female Brain Aging [2018]
  66. Mymenoplan.org [My Menoplan, United States]
  67. National Center for Complementary and Integrative Health: Dietary Supplements and Cognitive Function, Dementia, and Alzheimer’s Disease: What the Science Says
  68. Navigating Menopause: Expert Insights and Solutions | Dr Susan Davis | The Proof Podcast EP 245
  69. Perimenopause
  70. Perimenopause and Menopause Symptom Checklist
    Perimenopause Symptom Checklist
  71. Probiotics May Help Boost Mood and Cognitive Function
  72. Risks and Benefits of MHT
  73. Starting Oestrogen Hormone Therapy During or Soon After Menopause Could Cut Risk of Alzheimer’s – Study
  74. Staying Healthy During and After Menopause
  75. Study Linking HRT With Dementia Risk ‘Unhelpful’
  76. Systematic Review and Meta-Analysis of the Effects of Menopause Hormone Therapy on Risk of Alzheimer’s Disease and Dementia
  77. The 2022 Hormone Therapy Position Statement of The North American Menopause Society
  78. The Best Foods To Eat for Better Memory and Brain Health
  79. The Effect of Hormone Replacement Therapy on the Survival of UK Women: A Retrospective Cohort Study 1984−2017
  80. The Truth About Menopause Supplements | Dr Sarah Berry
  81. Therapy for the Effects of Menopause
  82. Tips To Help Manage Menopause Symptoms
  83. Top 4 Tips To Prevent Chronic Diseases
  84. Use of Menopausal Hormone Therapy and Risk of Dementia: Nested Case-Control Studies Using QResearch and CPRD Databases
  85. Video Series-2022: Hormone Therapy: Understanding the Risks and Benefits
  86. Video Series-2022: Perimenopause, Signs, Symptoms, and Solutions
  87. Video Series-2023: NAMS 2023 Nonhormone Therapies Position Statement for Bothersome Menopause Symptoms
  88. Video Series-2023: New FDA-Approved Nonhormone Option for the Treatment of Hot Flashes
  89. Video Series-2023: Racial and Ethnic Differences in the Menopause Experience
  90. Videos and Podcasts: Videos – Interviews: A Simple Approach To Menopause: The Menopause Quick Six (www.MQ6.ca)
  91. Videos and Podcasts: Videos – Interviews: How To Protect Your Brain Health At Menopause and Beyond
  92. Videos and Podcasts: Videos – Interviews: Prevention of Chronic Diseases In Women: Where Does MHT Fit In?
  93. Videos and Podcasts: Videos – Interviews: What Women Should Know About Menopause and Brain Fog
  94. Webinars: Previous – Clinical Climacteric Conundrums
  95. What Everyone Should Know About Menopause Symptoms
  96. What Is Dementia? Symptoms, Types, and Diagnosis
  97. Why Didn’t Anyone Tell Me This? Episode 3: Dr Annice Mukherjee: Your Essential Menopause Toolkit
  98. Why Is Dementia Different for Women?
  99. World Menopause Day 2022: Patient Information Leaflet – Brain Fog and Memory Difficulties in Menopause [Multiply Languages]
  100. World Menopause Day 2023Young Onset Dementia: Perimenopause and Menopause

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. HRT Benefits and Risks. Updated: November 2020:2. Women’s Health Concern https://www.womens-health-concern.org/help-and-advice/factsheets/hrt-know-benefits-risks/ Accessed: 16 October 2023
  2. Pourhadi, N., Mørch, L. S. Holm, E.A. Torp-Pederson, C., Meaidi, A. Menopausal Hormone Therapy and Dementia: Nationwide, Nested Case-Control Study. 28 June 2023. https://www.bmj.com/content/381/bmj-2022-072770
  3. Kantarci, K., Manson, JA, E. Menopausal Hormone Therapy and Dementia [Editorials]. 28 June 2023:381. https://www.bmj.com/content/381/bmj.p1404 Accessed: 16 October 2023
  4. HRT Benefits and Risks. Updated: November 2020:2. Women’s Health Concern https://www.womens-health-concern.org/help-and-advice/factsheets/hrt-know-benefits-risks/ Accessed: 16 October 2023
  5. Deciding About Hormone Therapy Use: Potential Risks. 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 16 October 2023
  6. Hamoda, H., Mukherjee, A., Morris, E., Baldeweg, S. E., Jayesena, C. N., Briggs, P., Moger, S. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause. First Published Online 12 June 2022 https://journals.sagepub.com/doi/full/10.1177/20533691221104879 Accessed: 16 October 2023
  7. Hormones and Dementia: Does Hormone Replacement Therapy Reduce Dementia Risk? Alzheimer’s Society https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/hormones-and-dementia Accessed: 16 October 2023
  8. Hogervorst, E., D’Donnell, E. and Hardy, R. Menopause: HRT’s Brain-Protecting Effect May Be Overstated. 11 May 2022 https://theconversation.com/menopause-hrts-brain-protecting-effect-may-be-overstated-182449 Accessed: 16 October 2023
  9. Hogervorst, E., D’Donnell, E. and Hardy, R. Menopause: HRT’s Brain-Protecting Effect May Be Overstated. 11 May 2022 https://theconversation.com/menopause-hrts-brain-protecting-effect-may-be-overstated-182449 Accessed: 16 October 2023
  10. Deciding About Hormone Therapy Use. 2022:1. North American Menopause Society https://www.menopause.org/docs/default-source/professional/menonote-deciding-about-ht-2022.pdf Accessed: 16 October 2023
Topic Last Updated: 30 November 2023 – Topic Last Reviewed: 16 October 2023

Print Friendly, PDF & Email
/by