Hormone Therapy and Tibolone

“Tibolone (brand name Livial) is a prescription medicine that is similar to taking combined HRT (oestrogen and progestogen). It’s taken as a tablet once a day”.1

Umbrella
What may the Hormone Therapy and Tibolone Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Livial
  • Menopausal Hormone Therapy (MHT)
  • Tibolone
  • Xyvion

Definition

What is Tibolone?

DotS the definition of Tibolone may vary. The Australasian Menopause Society’s (AMS) definition is:

  • “Tibolone acts as a combined oral hormone therapy for treating menopausal symptoms”.2

The (United Kingdom) NHS’s definition is:

“Tibolone (brand name Livial) is a prescription medicine that is similar to taking combined HRT (oestrogen and progestogen). It’s taken as a tablet once a day”.3

The (Australian) Jean Hailes for Women’s Health (JH) note:

“Tibolone is a synthetic hormone and its actions are similar to oestrogen, progesterone and testosterone”.4

Synthetic or Not

Is Tibolone synthetic?

Yes. In Tibolone As Menopausal Hormone Therapy: What Is Tibolone? the AMS elaborate on:

  • “Tibolone is a synthetic steroid molecule which is, in essence, a progestogen”.5

Vasomotor Symptoms

How effective is Tibolone for vasomotor symptoms such as hot flushes and night sweats?

In Tibolone As Menopausal Hormone Therapy: How Effective Is Tibolone? the AMS elaborate on:

“In randomized trials tibolone 2.5mg has been found to be more effective than placebo and less effective than standard dose combined MHT in controlling vasomotor symptoms”.6

Menopause Symptoms

How effective is Tibolone for menopause symptoms?

In Hormone Replacement Therapy (HRT) Alternatives – Tibolone the NHS note:

Hormone Therapy and Tibolone“It can help relieve symptoms such as hot flushes, low mood and reduced sex drive, although some studies have suggested it may not be as effective as combined HRT”.7

In Menopause Management: Hormone Replacement Therapy (HRT) – Tibolone (Livial or Xyvion): Testosterone – Symptoms It Assists In Preventing the JH elaborate on:

“It can help to improve mood and sleep quality, decrease hot flushes and improve general wellbeing. Tibolone may also help sex drive by improving vaginal secretions, increasing free testosterone and elevating mood”.8

In HRT: Which HRT? Tibolone the (British) Women’s Health Concern explain:

“Tibolone relieves menopausal symptoms, prevents bone loss, and may improve interest in sex”.9

Bone Loss

How effective is Tibolone in the prevention of bone loss?

In Tibolone As Menopausal Hormone Therapy: How Effective Is Tibolone? the AMS elaborate on:

  • “Tibolone has been found to be effective in the prevention of bone loss”.10

Breast Cancer Risk

Is there an association between Tibolone and breast cancer risk?

In Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion) the JH explain:

“Tibolone is not associated with an increased risk of breast cancer in women without breast cancer; however, the multinational study of women with menopausal symptoms and breast cancer showed that Tibolone increased the risk of recurrence compared to placebo”.11

Women With Breast Cancer

Is there an association between Tibolone and women with breast cancer?

In Menopause Management: Menopause Hormone Therapy (MHT) – Tibolone (Livial or Xyvion) the JH also note:

“It should also be noted that Tibolone may interfere with the effectiveness of breast cancer therapies, so is therefore not recommended for women with breast cancer”.12

Health Care Provider

What if I choose to use Tibolone?

If you choose to use Tibolone it may be in your best interest to also choose to talk to your health care provider about this.

One of the points of consensus about menopausal hormone therapy (MHT) in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.13

What is VTE?

VTE can be an abbreviation for Venous Thromboembolism.

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy and Tibolone?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

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Links

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  1. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT)
  2. Active Ingredient: Tibolone [Tibolone (Sandoz), Xyvion and Livial]
  3. BMS & WHC’s 2020 Recommendations on Hormone Replacement Therapy In Menopausal Women
  4. Bioidentical Hormones Explained – A British Menopause Society Video
  5. Bioidentical Hormones: Are They Safer?
  6. Brand Name Tibolone (Sandoz)
  7. Combined Menopausal Hormone Therapy (MHT)
  8. Complementary Medicine Options for Menopausal Symptoms
  9. Complementary and Alternative Therapies Explained – A British Menopause Society Video
  10. Compounded Bioidentical Hormone Therapy [Video]
  11. Consumer Health: Menopause, Hormone Replacement Therapy and Heart Health
  12. Deciding About Hormone Therapy
  13. Deciding About Hormone Therapy Use
  14. Decidir Sobre La Hormonoterapia
  15. Experiencing Vaginal Dryness? Here’s What You Need To Know
  16. Fast Facts: HRT and Breast Cancer Risk
  17. Find A Menopause Practitioner [United States and Other]
  18. Find An AMS Doctor [Australasian Menopause Society i.e. Australia and New Zealand]
  19. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  20. Global Consensus Position Statement on the Use of Testosterone Therapy for Women
  21. HRT
  22. HRT and Alternatives
  23. HRT and Breast Cancer: Overall Risks and Benefits Explained – A British Menopause Society Video
  24. HRT and the Risk of Breast Cancer Explained – A British Menopause Society Video
  25. HRT: Benefits and Risks
  26. HRT: Types, Doses and Regimens
  27. HRT: Which HRT? Tibolone
  28. Hormone Help Desk: ET, EPT, and More
  29. Hormone Replacement Therapy
  30. Hormone Replacement Therapy (HRT)
  31. Hormone Replacement Therapy (HRT) Explained – A British Menopause Society Video
  32. Hormone Replacement Therapy (HRT): Alternatives – Tibolone
  33. Hormone Replacement Therapy (HRT): Risks
  34. Hormone Replacement Therapy (HRT): Types
  35. Hormone Therapy In Postmenopausal Women: Primary Prevention of Chronic Conditions
  36. Hormone Therapy for Menopause
  37. Hormone Therapy: Is It Right for You?
  38. Hot Flashes: Manage Without Medication?
  39. Hot Flashes: What Can I Do?
  40. Index To Drug-Specific Information [United States]
  41. Lifestyle and Behaviour Changes for Menopausal Symptoms
  42. Lifestyle and Behavioural Modifications for Menopausal Symptoms
  43. Livial Tablets
  44. MHT Still Maligned & Misunderstood: Expert
  45. Making Choices At Menopause
  46. Managing Menopausal Symptoms—Hormone Replacement Therapy Is Not the Only Option!
  47. Mayo Clinic Minute: Help With Hot Flashes Due To Menopause [+ Video]
  48. Mayo Clinic Minute: Lifestyle Changes To Manage Menopause Symptoms [+ Video]
  49. Menopause
  50. Menopause
  51. Menopause
  52. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  53. Menopause Hormone Therapy: Who Shouldn’t Take It?
  54. Menopause Management: Hormone Replacement Therapy (HRT) – Tibolone or Livial
  55. Menopause Treatment
  56. Menopause: Diagnosis & Treatment
  57. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  58. Menopause: Medicines To Help You
  59. Menopause: Menopause – Hormone Treatments
  60. Menopause: Non-Hormonal Treatment & Relief for Hot Flashes
  61. Menopause: Symptoms & Causes
  62. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use
  63. National Center for Complementary and Integrative Health: How Safe Is This Product or Practice?
  64. National Center for Complementary and Integrative Health: Know the Science: How Medications and Supplements Can Interact
  65. National Center for Complementary and Integrative Health: Menopausal Symptoms: In Depth
  66. Natural Remedies To Help Manage Perimenopause Symptoms
  67. Natural Therapies & Supplements
  68. Oestrogen Only Menopausal Hormone Therapy
  69. Osteoporosis Explained – A British Menopause Society Video
  70. Revised Global Consensus Statement on Menopausal Hormone Therapy
  71. Risks and Benefits of MHT
  72. Sex & Sexual Health: Libido
  73. Short-Term and Long-Term Effects of Tibolone In Postmenopausal Women
  74. Supporting Women Through Menopause – Fact Sheet
  75. Testosterone Explained – A British Menopause Society Video
  76. Testosterone Therapy In Women: Does It Boost Sex Drive?
  77. The Menopause: Hormone Replacement Therapy (HRT) [+ Video: Is HRT Bad for You?]
  78. The Menopause: Menopause and Your Mental Wellbeing [+ Video: Menopause Only Affects You Physically!]
  79. The Menopause: Treating Menopause Symptoms [+ Video: Talking Menopause With Your GP]
  80. Tibolone As Adjunctive Treatment In Perimenopausal Depression
  81. Tibolone As Menopausal Hormone Therapy
  82. Urogenital Atrophy Explained – A British Menopause Society Video
  83. Vaginal Dryness
  84. Venous Thrombosis/Thromboembolism Risk and Menopausal Treatments
  85. Video Series-2020: What You Need To Know About Bioidentical Hormone Therapy
  86. Video Series-2021: Common Issues Surrounding Sexuality and Menopause
  87. Video Series-2021: How Menopause Symptoms Can Affect Your Quality of Life
  88. Video Series-2021: Treatment Options for Vaginal Dryness and Urinary Issues
  89. Video Series-2021: What Women Need to Know About Hormone Therapies
  90. Video Series-2022: Perimenopause, Signs, Symptoms, and Solutions
  91. Videos and Podcasts: Interviews and Podcasts – Interviews: Is Testosterone the Answer To Low Libido?
  92. Videos and Podcasts: Interviews and Podcasts – Interviews: The Menopause Blues
  93. Videos and Podcasts: World Menopause Day 2021 – Interviews: Bone Health
  94. Videos and Podcasts: World Menopause Day 2021 – Interviews: Bone Health What Why and How
  95. Vulvovaginal Symptoms After Menopause
  96. Webinars: Previous – Breast Cancer
  97. Webinars: Previous – Lessons From the Global Consensus on Testosterone for Women
  98. Webinars: Previous – Progestogen, Progestin, Progesterone: Why All the Confusion?
  99. Webinars: Previous – Update on Bone Health
  100. Women’s Wellness: Libido Drug To Help Women With Low Sexual Desire

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 04 January 2022
  2. Tibolone As Menopausal Hormone Therapy: Key Points. Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 04 January 2022
  3. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS  https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 04 January 2022
  4. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 13 July 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 04 January 2022
  5. Tibolone As Menopausal Hormone Therapy: What Is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 04 January 2022
  6. Tibolone As Menopausal Hormone Therapy: How Effective is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 04 January 2022
  7. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 04 January 2022
  8. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion): Testosterone – Symptoms It Assists In Preventing. Last Updated: 13 July 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 04 January 2022
  9. HRT: Which HRT? Tibolone. Reviewed: December 2017. British Women’s Health Concern https://www.womens-health-concern.org/help-and-advice/factsheets/hrt/ Accessed: 04 January 2022
  10. Tibolone As Menopausal Hormone Therapy: How Effective is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 04 January 2022
  11. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 13 July 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 04 January 2022
  12. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 13 July 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 04 January 2022
  13. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/wp-content/uploads/2020/08/global-consensus-hrt-2016-06.pdf Accessed: 04 January 2022

Topic Last Updated: 06 January 2022 – Topic Last Reviewed: 04 January 2022
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