Hormone Therapy and Tibolone

“Tibolone (brand name Livial) is a prescription medicine that is similar to taking combined HRT (oestrogen and progestogen). It’s taken as a tablet once a day”.1

Umbrella
What may the Hormone Therapy and Tibolone Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Livial
  • Menopausal Hormone Therapy (MHT)
  • Tibolone
  • Xyvion

Definition

What is Tibolone?

DotS the definition of Tibolone may vary. The Australasian Menopause Society’s (AMS) definition is:

  • “Tibolone acts as a combined oral hormone therapy for treating menopausal symptoms”.2

The (United Kingdom) NHS’s definition is:

“Tibolone (brand name Livial) is a prescription medicine that is similar to taking combined HRT (oestrogen and progestogen). It’s taken as a tablet once a day”.3

The (Australian) Jean Hailes for Women’s Health (JH) note:

“Tibolone is a synthetic hormone and its actions are similar to oestrogen, progesterone and testosterone”.4

Synthetic or Not

Is Tibolone synthetic?

Yes. In Tibolone As Menopausal Hormone Therapy: What Is Tibolone? the AMS elaborate on:

  • “Tibolone is a synthetic steroid molecule which is, in essence, a progestogen”.5

Vasomotor Symptoms

How effective is Tibolone for vasomotor symptoms such as hot flushes and night sweats?

In Tibolone As Menopausal Hormone Therapy: How Effective Is Tibolone? the AMS elaborate on:

“In randomized trials tibolone 2.5mg has been found to be more effective than placebo and less effective than standard dose combined MHT in controlling vasomotor symptoms”.6

Menopause Symptoms

How effective is Tibolone for menopause symptoms?

In Hormone Replacement Therapy (HRT) Alternatives – Tibolone the NHS note:

“It can help relieve symptoms such as hot flushes, low mood and reduced sex drive, although some studies have suggested it may not be as effective as combined HRT”.7

In Menopause Management: Hormone Replacement Therapy (HRT) – Tibolone (Livial or Xyvion): Testosterone – Symptoms It Assists In Preventing the JH elaborate on:

“It can help to improve mood and sleep quality, decrease hot flushes and improve general wellbeing. Tibolone may also help sex drive by improving vaginal secretions, increasing free testosterone and elevating mood”.8

In HRT: Which HRT? Tibolone the (British) Women’s Health Concern explain:

“Tibolone relieves menopausal symptoms, prevents bone loss, and may improve interest in sex”.9

Bone Loss

How effective is Tibolone in the prevention of bone loss?

In Tibolone As Menopausal Hormone Therapy: How Effective Is Tibolone? the AMS elaborate on:

  • “Tibolone has been found to be effective in the prevention of bone loss”.10

Breast Cancer Risk

Is there an association between Tibolone and breast cancer risk?

In Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion) the JH explain:

“Tibolone is not associated with an increased risk of breast cancer in women without breast cancer; however, the multinational study of women with menopausal symptoms and breast cancer showed that Tibolone increased the risk of recurrence compared to placebo”.11

Women With Breast Cancer

Is there an association between Tibolone and breast cancer therapies?

In Menopause Management: Menopause Hormone Therapy (MHT) – Tibolone (Livial or Xyvion) the JH also note:

“It should also be noted that Tibolone may interfere with the effectiveness of breast cancer therapies, so is therefore not recommended for women with breast cancer”.12

Health Care Provider

What if I choose to use Tibolone?

If you choose to use Tibolone it may be in your best interest to also choose to talk to your health care provider about this.

One of the points of consensus about menopausal hormone therapy (MHT) in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.13

What is VTE?

VTE can be an abbreviation for Venous Thromboembolism.

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy and Tibolone?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

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Links

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  1. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 6. Myth – Complementary Medicines and Therapies Are As Effective As MHT and Safer
  2. 9 Myths and Misunderstandings About Menopausal Hormone Therapy (MHT): 7. Myth – Compounded Bioidentical Hormone Therapy Is Safer Than Conventional MHT
  3. Active Ingredient: Tibolone [Tibolone (Sandoz), Xyvion and Livial]
  4. BMS & WHC’s 2020 Recommendations on Hormone Replacement Therapy In Menopausal Women
  5. Bioidentical Hormones Explained – A British Menopause Society Video
  6. Bioidentical Hormones: Are They Safer?
  7. Brand Name Tibolone (Sandoz)
  8. Combined Menopausal Hormone Therapy (MHT)
  9. Complementary Medicine Options for Menopausal Symptoms
  10. Complementary and Alternative Therapies Explained – A British Menopause Society Video
  11. Compounded Bioidentical Hormone Therapy [Video]
  12. Deciding About Hormone Therapy
  13. Deciding About Hormone Therapy Use
  14. Decidir Sobre La Hormonoterapia
  15. Experiencing Vaginal Dryness? Here’s What You Need To Know
  16. Fast Facts: HRT and Breast Cancer Risk
  17. Global Consensus Position Statement on the Use of Testosterone Therapy for Women
  18. HRT
  19. HRT and Alternatives
  20. HRT and Breast Cancer: Overall Risks and Benefits Explained – A British Menopause Society Video
  21. HRT and the Risk of Breast Cancer Explained – A British Menopause Society Video
  22. HRT: Benefits and Risks
  23. HRT: Which HRT? Tibolone
  24. Hormone Help Desk: ET, EPT, and More
  25. Hormone Replacement Therapy
  26. Hormone Replacement Therapy (HRT)
  27. Hormone Replacement Therapy (HRT) Explained – A British Menopause Society Video
  28. Hormone Replacement Therapy (HRT): Alternatives – Tibolone
  29. Hormone Replacement Therapy (HRT): Risks
  30. Hormone Replacement Therapy (HRT): Types
  31. Hormone Replacement Therapy Safe, Despite Rare Blood Clot Risks From Tablets
  32. Hormone Therapy In Postmenopausal Women: Primary Prevention of Chronic Conditions
  33. Hormone Therapy for Menopause
  34. Hormone Therapy: Is It Right for You?
  35. Hot Flashes: Manage Without Medication?
  36. Hot Flashes: What Can I Do?
  37. How do I deal with vaginal atrophy? — Ask Dr Jean
  38. Index To Drug-Specific Information [United States]
  39. Information About Menopause [Multiply Languages] [Videos]
  40. Lifestyle and Behaviour Changes for Menopausal Symptoms
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  43. Managing Menopause: Don’t Let Symptoms of Menopause Reduce Your Quality of Life
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  47. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  48. Menopause Hormone Therapy: Who Shouldn’t Take It?
  49. Menopause Management: Hormone Replacement Therapy (HRT) – Tibolone or Livial
  50. Menopause Matters
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  52. Menopause – Is Menopausal Hormone Therapy (HRT) Safe? [Multiply Languages] [Video]
  53. Menopause – Non-Hormonal Treatment Options [Multiply Languages] [Video]
  54. Menopause – What Is Menopausal Hormone Therapy (HRT)? [Multiply Languages] [Video]
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  56. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  57. Menopause: Hormone Replacement Therapy (HRT) [Video Interview Stories]
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  62. Menopause: Symptoms & Causes
  63. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use
  64. National Center for Complementary and Integrative Health: How Safe Is This Product or Practice?
  65. National Center for Complementary and Integrative Health: Know the Science: How Medications and Supplements Can Interact
  66. National Center for Complementary and Integrative Health: Menopausal Symptoms: In Depth
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  68. Non-Hormonal Treatment Options for Menopausal Symptoms
  69. NonHormonal Treatments for Menopausal Symptoms
  70. Oestrogen Only Menopausal Hormone Therapy
  71. Osteoporosis Explained – A British Menopause Society Video
  72. Revised Global Consensus Statement on Menopausal Hormone Therapy
  73. Risks and Benefits of MHT
  74. Sex & Sexual Health: Libido
  75. Short-Term and Long-Term Effects of Tibolone In Postmenopausal Women
  76. Supporting Women Through Menopause – Fact Sheet
  77. Testosterone Explained – A British Menopause Society Video
  78. Testosterone Therapy In Women: Does It Boost Sex Drive?
  79. Tibolone As Adjunctive Treatment In Perimenopausal Depression
  80. Tibolone As Menopausal Hormone Therapy
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  82. Vaginal Dryness
  83. Vaginal Dryness
  84. Venous Thrombosis/Thromboembolism Risk and Menopausal Treatments
  85. Vulvovaginal Symptoms After Menopause
  86. Video Series-2020 – TSECs—A New Treatment Option for Hot Flashes and Night Sweats
  87. Video Series-2020 – What You Need To Know About Bioidentical Hormone Therapy
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  89. Video Series-2021 – Common Issues Surrounding Sexuality and Menopause
  90. Video Series-2021 – Treatment Options for Vaginal Dryness and Urinary Issues
  91. Video Series-2021 – What Women Need To Know About Hormone Therapies
  92. Vulvovaginal Symptoms After Menopause
  93. Webinars: Other Webinars – Lessons From the Global Consensus on Testosterone for Women
  94. Webinars: Other Webinars – Progestogen, Progestin, Progesterone: Why All the Confusion?
  95. Webinars: Other Webinars – VVA – The Silent Epidemic [Vulvovaginal Atrophy]
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  98. Women’s Wellness: Libido Drug To Help Women With Low Sexual Desire
  99. Women’s Wellness: Treating Hot Flashes and Night Sweats Without Hormones [+ Video]
  100. World Menopause Day: World Menopause Day 2019 – Testosterone for Women At Midlife [Multiply Languages]

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 12 May 2021
  2. Tibolone As Menopausal Hormone Therapy: Key Points. Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 12 May 2021
  3. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS  https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 12 May 2021
  4. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 20 April 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 12 May 2021
  5. Tibolone As Menopausal Hormone Therapy: What Is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 12 May 2021
  6. Tibolone As Menopausal Hormone Therapy: How Effective is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 12 May 2021
  7. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 12 May 2021
  8. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion): Testosterone – Symptoms It Assists In Preventing. Last Updated: 20 April 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 12 May 2021
  9. HRT: Which HRT? Tibolone. Reviewed: December 2017. British Women’s Health Concern https://www.womens-health-concern.org/help-and-advice/factsheets/hrt/ Accessed: 12 May 2021
  10. Tibolone As Menopausal Hormone Therapy: How Effective is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 12 May 2021
  11. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 20 April 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 12 May 2021
  12. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 20 April 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 12 May 2021
  13. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/wp-content/uploads/2020/08/global-consensus-hrt-2016-06.pdf Accessed: 12 May 2021

Topic Last Updated: 12 May 2021 – Topic Last Reviewed: 12 May 2021
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