Hormone Therapy and Tibolone

“Tibolone (brand name Livial) is a prescription medicine
that is similar to taking combined HRT (oestrogen and
progestogen). It’s taken as a tablet once a day”.1

Umbrella
What may the Hormone Therapy and Tibolone Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Livial
  • Menopausal Hormone Therapy (MHT)
  • Tibolone
  • Xyvion

Definition

What is Tibolone?

DotS the definition of Tibolone may vary. The Australasian Menopause Society’s (AMS) definition is:

  • “Tibolone acts as a combined oral hormone therapy for treating menopausal symptoms”.2

The (United Kingdom) NHS’s definition is:

“Tibolone (brand name Livial) is a prescription medicine that is similar to taking combined HRT (oestrogen and progestogen). It’s taken as a tablet once a day”.3

The (Australian) Jean Hailes for Women’s Health (JH) note:

“Tibolone is a synthetic hormone and its actions are similar to oestrogen, progesterone and testosterone”.4

Continuous

Is Tibolone continuous?

In HRT: Which HRT? Tibolone the (British) Women’s Health Concern (WHC) explain:

“As with other continuous therapies, is normally prescribed at least 12 months after the last menstrual period, so many women switch to these continuous types after taking a sequential HRT”.5

Vasomotor Symptoms

How effective is Tibolone for vasomotor symptoms such as hot flushes and night sweats?

In Tibolone As Menopausal Hormone Therapy: How Effective Is Tibolone? the AMS elaborate on:

“In randomized trials tibolone 2.5mg has been found to be more effective than placebo and less effective than standard dose combined MHT in controlling vasomotor symptoms”.6

Menopause Symptoms

How effective is Tibolone for menopause symptoms?

In Hormone Replacement Therapy (HRT) Alternatives – Tibolone the NHS note:

Hormone Therapy and Tibolone“It can help relieve symptoms such as hot flushes, low mood and reduced sex drive, although some studies have suggested it may not be as effective as combined HRT”.7

In Menopause Management: Hormone Replacement Therapy (HRT) – Tibolone (Livial or Xyvion): Testosterone – Symptoms It Assists In Preventing the JH elaborate on:

“It can help to improve mood and sleep quality, decrease hot flushes and improve general wellbeing”.8

In HRT: Which HRT? Tibolone the (British) Women’s Health Concern (WHC) explain:

“Tibolone has combined oestrogen, progestogen and testosterone effects and relieves menopausal symptoms, prevents bone loss, and may improve interest in sex”.9

Bone Loss

How effective is Tibolone in the prevention of bone loss?

In Tibolone As Menopausal Hormone Therapy: How Effective Is Tibolone? the AMS elaborate on:

  • “Tibolone has been found to be effective in the prevention of bone loss”.10

Sex Drive

How effective is Tibolone in helping sex drive?

The JH note:

“Tibolone may also help sex drive by improving vaginal secretions, increasing free testosterone and elevating mood”.11

Endometriosis and Fibroids

Is Tibolone useful in women known to have endometriosis and fibroids?

The WHC note:

“Tibolone has also been shown to be particularly useful in women who are known to have endometriosis and fibroids as it does not appear to stimulate these conditions”.12

Women With Breast Cancer

Is there an association between Tibolone and women with breast cancer?

In Menopause Management: Menopause Hormone Therapy (MHT) – Tibolone (Livial or Xyvion) the JH also note:

“It should also be noted that Tibolone may interfere with the effectiveness of breast cancer therapies, so is therefore not recommended for women with breast cancer”.13

Health Care Provider

What if I choose to use Tibolone?

If you choose to use Tibolone it may be in your best interest to also choose to talk to your health care provider about this.

One of the points of consensus about menopausal hormone therapy (MHT) in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.14

What is VTE?

VTE can be an abbreviation for Venous Thromboembolism.

Health Topics A-Z

Where may I find Health Topics related to Hormone Therapy and Tibolone?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

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Your Country may have Links similar to:

Links

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  1. Active Ingredient: Tibolone [Tibolone (Sandoz), Xyvion and Livial]
  2. Askearlymenopause.org [Ask EM] [+ Video: What Is Early Menopause?]
  3. BMS & WHC’s 2020 Recommendations on Hormone Replacement Therapy In Menopausal Women
  4. Bioidentical Hormones Explained – A British Menopause Society Video
  5. Bioidentical Hormones: Are They Safer?
  6. Brand Name Tibolone (Sandoz)
  7. Combined Menopausal Hormone Therapy (MHT)
  8. Complementary Medicine Options for Menopausal Symptoms
  9. Complementary and Alternative Therapies Explained – A British Menopause Society Video
  10. Consumer Health: Menopause, Hormone Replacement Therapy and Heart Health
  11. Deciding About Hormone Therapy Use
  12. EMAS Menopause Essentials
  13. EMAS Replay: Risk Assessment for MHT – When, To Whom, Which, and How Long? [Multiply Languages]
  14. EMAS Replay: Role of Progestogens In MHT [ Multiply Languages]
  15. EMAS Replay: The Relevance of Estrogen and Progestogen Choice for Breast Safety During MHT [Multiply Languages]
  16. Fast Facts: HRT and Breast Cancer Risk
  17. Find A Menopause Practitioner [United States and Other]
  18. Find An AMS Doctor [Australasian Menopause Society i.e. Australia and New Zealand]
  19. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  20. Global Consensus Position Statement on the Use of Testosterone Therapy for Women
  21. HRT
  22. HRT and Alternatives
  23. HRT and Breast Cancer: Overall Risks and Benefits Explained – A British Menopause Society Video
  24. HRT and the Risk of Breast Cancer Explained – A British Menopause Society Video
  25. HRT: Benefits and Risks
  26. HRT: Types, Doses and Regimens
  27. HRT: Which HRT? Tibolone
  28. Hormone Help Desk: ET, EPT, and More
  29. Hormone Replacement Therapy
  30. Hormone Replacement Therapy (HRT)
  31. Hormone Replacement Therapy (HRT) Explained – A British Menopause Society Video
  32. Hormone Replacement Therapy (HRT): Alternatives – Tibolone
  33. Hormone Replacement Therapy (HRT): Risks
  34. Hormone Replacement Therapy (HRT): Types
  35. Hormone Therapy In Postmenopausal Women: Primary Prevention of Chronic Conditions
  36. Hormone Therapy for Menopause
  37. Hormone Therapy: Is It Right for You?
  38. Hot Flashes: Manage Without Medication?
  39. Index To Drug-Specific Information [United States]
  40. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause
  41. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – Hormone Replacement Therapy (HRT) [+ Video: Is HRT Bad for You?]
  42. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – Signs and Symptoms [+ Video: Talking Menopause With Your GP]
  43. Lifestyle and Behavioural Modifications for Menopausal Symptoms
  44. Livial Tablets
  45. MHT Still Maligned & Misunderstood: Expert
  46. Managing Menopausal Symptoms—Hormone Replacement Therapy Is Not the Only Option!
  47. Mayo Clinic Minute: Help With Hot Flashes Due To Menopause [+ Video]
  48. Mayo Clinic Minute: How Lifestyle Changes May Help Manage Menopause Symptoms
  49. Menopausal Hormone Therapy
  50. Menopause
  51. Menopause
  52. Menopause
  53. Menopause FAQs: Hormone Therapy for Menopause Symptoms
  54. Menopause Hormone Therapy: Who Shouldn’t Take It?
  55. Menopause Management: Hormone Replacement Therapy (HRT) – Tibolone or Livial
  56. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
    Hormone Therapy and Tibolone
  57. Menopause Preparedness Toolkit: A Woman’s Empowerment Guide
  58. Menopause Treatment
  59. Menopause: Diagnosis & Treatment
  60. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  61. Menopause: Medicines To Help You
  62. Menopause: Menopause – Hormone Treatments
  63. Menopause: Symptoms & Causes
  64. NAMS 2017 Position Statement Updates Guidelines for Hormone Therapy Use
  65. National Center for Complementary and Integrative Health: How Safe Is This Product or Practice?
  66. National Center for Complementary and Integrative Health: Know the Science: How Medications and Supplements Can Interact
  67. National Center for Complementary and Integrative Health: Menopausal Symptoms: In Depth
  68. Natural Remedies To Help Manage Perimenopause Symptoms
  69. Non-Estrogen Treatments for Menopausal Symptoms
  70. Oestrogen Only Menopausal Hormone Therapy
  71. Osteoporosis Explained – A British Menopause Society Video
  72. Revised Global Consensus Statement on Menopausal Hormone Therapy
  73. Risks and Benefits of MHT
  74. Short-Term and Long-Term Effects of Tibolone In Postmenopausal Women
  75. Supporting Women Through Menopause – Fact Sheet
  76. Testosterone Explained – A British Menopause Society Video
  77. Testosterone Therapy In Women: Does It Boost Sex Drive?
  78. Tibolone As Adjunctive Treatment In Perimenopausal Depression
  79. Tibolone As Menopausal Hormone Therapy
  80. Urogenital Atrophy Explained – A British Menopause Society Video
  81. Vaginal Dryness
  82. Venous Thrombosis/Thromboembolism Risk and Menopausal Treatments
  83. Video Series-2020: What You Need To Know About Bioidentical Hormone Therapy
  84. Video Series-2021: Common Issues Surrounding Sexuality and Menopause
  85. Video Series-2021: How Menopause Symptoms Can Affect Your Quality of Life
  86. Video Series-2021: Treatment Options for Vaginal Dryness and Urinary Issues
  87. Video Series-2021: What Women Need To Know About Hormone Therapies
  88. Video Series-2022: Discussing Sexual Health Concerns With Your Health Care Professional
  89. Video Series-2022: Hormone Therapy: Understanding the Risks and Benefits
  90. Video Series-2022: Perimenopause, Signs, Symptoms, and Solutions
  91. Video Series-2022: Understanding Screening Guidelines for Breast Cancer and the Importance of Identifying Risk Factors
  92. Videos and Podcasts: Interviews and Podcasts – Interviews: Is Testosterone the Answer To Low Libido?
  93. Videos and Podcasts: Interviews and Podcasts – Interviews: The Menopause Blues
  94. Videos and Podcasts: World Menopause Day 2021 – Interviews: Bone Health
  95. Videos and Podcasts: World Menopause Day 2021 – Interviews: Bone Health What Why and How
  96. Vulvovaginal Symptoms After Menopause
  97. Webinars: Previous – Lessons From the Global Consensus on Testosterone for Women
  98. Webinars: Previous – Progestogen, Progestin, Progesterone: Why All the Confusion?
  99. Webinars: Previous – Update on Bone Health
  100. What Are the Benefits and Risks of HRT?

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 06 July 2022
  2. Tibolone As Menopausal Hormone Therapy: Key Points. Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 06 July 2022
  3. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 06 July 2022
  4. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 13 July 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 06 July 2022
  5. HRT: Which HRT? Tibolone. Reviewed: November 2021. British Women’s Health Concern https://www.womens-health-concern.org/help-and-advice/factsheets/hrt/ Accessed: 06 July 2022
  6. Tibolone As Menopausal Hormone Therapy: How Effective is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 06 July 2022
  7. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 06 July 2022
  8. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion): Testosterone – Symptoms It Assists In Preventing. Last Updated: 13 July 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 06 July 2022
  9. HRT: Which HRT? Tibolone. Reviewed: November 2021. British Women’s Health Concern https://www.womens-health-concern.org/help-and-advice/factsheets/hrt/ Accessed: 06 July 2022
  10. Tibolone As Menopausal Hormone Therapy: How Effective is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 06 July 2022
  11. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 13 July 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 06 July 2022
  12. HRT: Which HRT? Tibolone. Reviewed: November 2021. British Women’s Health Concern https://www.womens-health-concern.org/help-and-advice/factsheets/hrt/ Accessed: 06 July 2022
  13. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 13 July 2021 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 06 July 2022
  14. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/wp-content/uploads/2020/08/global-consensus-hrt-2016-06.pdf Accessed: 06 July 2022

Topic Last Updated: 06 July 2022 – Topic Last Reviewed: 06 July 2022
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