“Tibolone (brand name Livial) is a prescription medicine that is similar to taking combined HRT (oestrogen and progestogen). It’s taken as a tablet once a day”.1

Umbrella
What may the Hormone Therapy and Tibolone Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)
  • Tibolone

Definition

What is Tibolone?

DotS the definition of Tibolone may vary. The Australasian Menopause Society’s (AMS) definition is:

  • “Tibolone acts as a combined oral hormone therapy for treating menopausal symptoms”.2

The (United Kingdom) NHS’s (National Health Service) definition is:

“Tibolone (brand name Livial) is a prescription medicine that is similar to taking combined HRT (oestrogen and progestogen). It’s taken as a tablet once a day”.3

The (Australian) Jean Hailes for Women’s Health (JH) note:

“Tibolone is a synthetic hormone and its actions are similar to oestrogen, progesterone and testosterone”.4

Synthetic or Not

Is Tibolone synthetic?

Yes. In Tibolone As Menopausal Hormone Therapy: What Is Tibolone? the AMS elaborate on:

  • “Tibolone is a synthetic steroid molecule which is, in essence, a progestogen”.5

Vasomotor Symptoms

How effective is Tibolone for vasomotor symptoms such as hot flushes and night sweats?

In Tibolone As Menopausal Hormone Therapy: How Effective Is Tibolone? the AMS elaborate on:

“In randomized trials tibolone 2.5mg has been found to be more effective than placebo and less effective than standard dose combined MHT in controlling vasomotor symptoms”.6

Menopause Symptoms

How effective is Tibolone for menopause symptoms?

In Hormone Replacement Therapy (HRT) Alternatives – Tibolone the NHS note:

“It can help relieve symptoms such as hot flushes, low mood and reduced sex drive, although some studies have suggested it may not be as effective as combined HRT”.7

In Menopause Management: Hormone Replacement Therapy (HRT) – Tibolone (Livial or Xyvion) the JH elaborate on:

“It can help to improve mood and sleep quality, decrease hot flushes and improve general wellbeing. Tibolone may also help sex drive by improving vaginal secretions, increasing free testosterone and elevating mood”.8

In HRT: Which HRT? Tibolone the (British) Women’s Health Concern explain:

“Tibolone relieves menopausal symptoms, prevents bone loss, and may improve interest in sex”.9

Bone Loss

How effective is Tibolone in the prevention of bone loss?

In Tibolone As Menopausal Hormone Therapy: How Effective Is Tibolone? the AMS elaborate on:

  • “Tibolone has been found to be effective in the prevention of bone loss”.10

Breast Cancer Risk

Is there an association between Tibolone and breast cancer risk?

In Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion) the JH explain:

“Tibolone is not associated with an increased risk of breast cancer in women without breast cancer; however, the multinational study of women with menopausal symptoms and breast cancer showed that Tibolone increased the risk of recurrence compared to placebo”.11

Women With Breast Cancer

Is there an association between Tibolone and breast cancer therapies?

In Menopause Management: Menopause Hormone Therapy (MHT) – Tibolone (Livial or Xyvion) the JH also note:

“It should also be noted that Tibolone may interfere with the effectiveness of breast cancer therapies, so is therefore not recommended for women with breast cancer”.12

Health Care Provider

What if I choose to use Tibolone?

If you choose to use Tibolone it may be in your best interest to also choose to talk to your health care provider about this.

One of the points of consensus about menopausal hormone therapy (MHT) in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.13

What is VTE?

VTE can be an abbreviation for Venous Thromboembolism.

Health Topics A-Z

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Links

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Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS (National Health Service) https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 01 July 2020
  2. Tibolone As Menopausal Hormone Therapy: Key Points. Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 01 July 2020
  3. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS (National Health Service) https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 01 July 2020
  4. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 07 April 2020 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 01 July 2020
  5. Tibolone As Menopausal Hormone Therapy: What Is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 01 July 2020
  6. Tibolone As Menopausal Hormone Therapy: How Effective is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 01 July 2020
  7. Hormone Replacement Therapy (HRT): Alternatives – Tibolone. Page Last Reviewed: 09 September 2019. NHS (National Health Service) https://www.nhs.uk/conditions/hormone-replacement-therapy-hrt/alternatives/#tibolone Accessed: 01 July 2020
  8. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 07 April 2020 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 01 July 2020
  9. HRT: Which HRT? Tibolone. Reviewed: December 2017. British Women’s Health Concern https://www.womens-health-concern.org/help-and-advice/factsheets/hrt/ Accessed: 01 July 2020
  10. Tibolone As Menopausal Hormone Therapy: How Effective is Tibolone? Content Updated December 2018. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/793-tibolone-for-post-menopausal-women Accessed: 01 July 2020
  11. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 07 April 2020 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 01 July 2020
  12. Menopause Management: Menopausal Hormone Therapy (MHT) – Tibolone (Livial or Xyvion). Last Updated: 07 April 2020 | Last Reviewed: 17 December 2017. Jean Hailes for Women’s Health https://jeanhailes.org.au/health-a-z/menopause/menopause-management Accessed: 01 July 2020
  13. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/manage/images/pdf/ba6379e868044bec13015ac2b84f2753.pdf Accessed: 01 July 2020

Topic Last Updated: 01 July 2020 – Topic Last Reviewed: 01 July 2020
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