Hormone Therapy and Tibolone

“Tibolone is a type of hormone replacement therapy (HRT)
that contains a synthetic (artificial) hormone. Your body
breaks down tibolone to make substances that work in a…”.1

Umbrella
What may the Hormone Therapy and Tibolone Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Livial
  • Menopausal Hormone Therapy (MHT)
  • Tibolone
  • Xyvion

Definition

What is Tibolone?

DotS the definition of Tibolone may vary. In Tibolone Brand Name: Livial – About Tibolone the (United Kingdom) NHS’s definition is:

“Tibolone is a type of hormone replacement therapy (HRT) that contains a synthetic (artificial) hormone. Your body breaks down tibolone to make substances that work in a similar way to the hormones oestrogen, progesterone and testosterone”.2

In Menopausal Hormone Therapy the European Menopause and Andropause Society’s definition is:

  • “Tibolone is a synthetic steroid with estrogenic, progestogenic and weak androgenic activity used to manage menopausal symptoms and urogenital atrophy in postmenopausal women”.3

Bleed-Free

Is Tibolone bleed-free?

On page two in HRT: Which HRT? Tibolone the (British) Women’s Health Concern’s (WHC) note:

“The first “bleed-free” HRT contains a synthetic hormone known as Tibolone, which is taken orally every day. Tibolone has combined oestrogen, progestogen and testosterone effects and relieves menopausal symptoms, prevents bone loss, and may improve interest in sex. As with other continuous therapies, it is normally prescribed at least 12 months after the last menstrual period, so many women switch to these continuous types after taking a sequential HRT”.4

Menopause Symptoms

What menopause symptoms does Tibolone help to improve?

In Tibolone Brand Name: Livial – About Tibolone the NHS note:

Hormone Therapy and Tibolone“Tibolone helps to improve menopause symptoms, such as hot flushes, low mood and vaginal dryness or irritation”.5

In Tibolone As Menopausal Hormone Therapy: Summary, updated September 2023, the Australasian Menopause Society (AMS) explain:

“Tibolone is indicated for the management of vasomotor symptoms associated with the menopause and for the prevention of bone loss. It can be considered an alternative to conventional MHT where improvement in libido is desired”.6

In The 2023 Practitioner’s Toolkit for Managing Menopause: The 2023 Practitioner’s Toolkit for Managing the Menopause Supporting Notes – Management: MHT Formulations and Options: Tibolone, published online 01 December 2023, the authors also note:

“It may improve sexual interest and responsiveness. Breast tenderness is uncommon and tibolone does not increase mammographic density”.7

Osteoporosis

How useful is Tibolone in women who are known to have endometriosis and fibroids?

The NHS note:

“It can also be prescribed to help stop your bones getting thinner after the menopause (osteoporosis)”.8

Endometriosis and Fibroids

How useful is Tibolone in women who are known to have endometriosis and fibroids?

On page two in HRT: Which HRT? Tibolone the WHC explain:

“Tibolone has also been shown to be particularly useful in women who are known to have endometriosis and fibroids as it does not appear to stimulate these conditions”.9

Health Care Provider

What if I choose to use Tibolone?

If you choose to use Tibolone it may be in your best interest to also choose to talk to your health care provider about this.

In Tibolone As Menopausal Hormone Therapy: Summary the AMS note:

“It is not recommended for use in women with a history of breast cancer and should be used with caution in women over age 60 because of the increased stroke risk”.10

On page two in HRT: Which HRT? Tibolone the WHC elaborate on:

“Irregular bleeding or spotting can occur during the first 4-6 months of taking continuous combined HRT or Tibolone, and is not a cause for alarm. However, you should consult your doctor if you get heavy (rather than light) bleeding, if it lasts for more than six months, or if bleeding starts suddenly after some time without bleeding. Irregular bleeding may sometimes be improved by changing the type or route of HRT”.11

In Tibolone Brand Name: Livial – About Tibolone: Key Facts the NHS elaborate on:

  • “It’s important to see your doctor at least once a year for a check-up and to review whether you need to keep taking tibolone”.12

Health Topics A-Z

Where may I find Health Topics A-Z related to Hormone Therapy and Tibolone?

In Health Topics A-Z you may find:

Health Topics A-Z

Links

Where may I find Links related to Hormone Therapy and Tibolone?

Your Country may have Links similar to:

Links

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New or Updated

  1. 8 Myths and Truths About Menopausal Hot Flashes
  2. Active Ingredient: Tibolone [Tibolone (Sandoz), Xyvion and Livial]
  3. Askearlymenopause.org [Ask EM] [+ Video: What Is Early Menopause?]
  4. BMS Statement on Testosterone
  5. BMS TV: HRT and Breast Cancer: Overall Risks and Benefits
  6. Hormone Therapy and TiboloneBMS TV: HRT and the Risk of Breast Cancer
  7. BMS TV: Hormone Replacement Therapy (HRT)
  8. BMS TV: Testosterone Explained
  9. Bioidentical Hormones: Are They Safer?
  10. Brand Name Tibolone (Sandoz)
  11. Build Better Bones.org [International Osteoporosis Foundation]
  12. Deciding About Hormone Therapy Use
  13. Dr Louise Newson: The Truth About the Menopause & HRT
  14. Emotional Wellness In Menopause
  15. Find A Menopause Practitioner [United States and Other]
  16. Find An AMS Doctor [Australasian Menopause Society i.e. Australia and New Zealand]
  17. Find Your Nearest BMS Menopause Specialist [British Menopause Society]
  18. Guidance on Menopausal Hormone Therapy
  19. HRT
  20. HRT & Menopause Extra
  21. HRT – Types, Doses and Regimens
  22. HRT: Benefits and Risks
  23. Hormone Replacement Therapy (HRT)
  24. Hormone Replacement Therapy (HRT): Benefits and Risks of Hormone Replacement Therapy (HRT)
  25. Hormone Replacement Therapy (HRT): Side Effects of Hormone Replacement Therapy (HRT)
  26. Hormone Replacement Therapy (HRT): Types of Hormone Replacement Therapy (HRT)
  27. Hormone Therapy for Menopause
  28. Hormone Therapy: Is It Right for You?
  29. Hot Flashes
  30. Hot Flashes
  31. Hot Flashes: What Can I Do? [+ Video: What Are the Signs and Symptoms of Menopause?]
  32. How Mindfulness Meditation Improves Mental Health
  33. How To Find Relief for Hot Flashes At Night
  34. I Forgot To Ask the Doctor – E9: The Menopause: Can Every Woman That Wants It Have HRT?
  35. Joint Position Statement By the British Menopause Society, Royal College of Obstetricians and Gynaecologists and Society for Endocrinology on Best Practice Recommendations for the Care of Women Experiencing the Menopause
  36. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – After the Menopause
  37. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – Hormone Replacement Therapy (HRT) [+ Video: Is HRT Bad for You?]
  38. Later Years (Around 50 Years and Over): Menopause and Post Menopause Health – Signs and Symptoms of Menopause [+ Video: Talking Menopause With Your GP]
  39. Livial Tablets
  40. Mastering Midlife Mood Changes With Marlene Freeman, MD
  41. Mayo Clinic Minute: Help With Hot Flashes Due To Menopause [+ Video Courtesy: Mayo Clinic News Network]
  42. Menopausal Hormone Therapy
  43. Menopause
  44. Menopause Management Options
  45. Menopause Map: Downloadable Resources – My Personal Path Print Tools: Questions for Your Health Care Provider
    Hormone Therapy and Tibolone
  46. Menopause Map: Downloadable Resources – Stages of Menopause: Postmenopause
    Postmenopause
  47. Menopause Patient Information [Videos] 2. Talking To Your GP About Menopause
  48. Menopause Patient Information [Videos] 3. The Risks & Benefits of HRT
  49. Menopause Patient Information [Videos] 4. The Different Types of HRT
  50. Menopause Preparedness Toolkit Video Series: Common Conditions Associated With Menopause and Midlife
  51. Menopause Preparedness Toolkit Video Series: Treating Vasomotor Symptoms of Menopause
  52. Menopause Preparedness Toolkit: A Woman’s Empowerment Guide
  53. Menopause Symptoms: Mayo Clinic Expert Outlines Hormone and Nonhormonal Therapies
  54. Menopause Treatment
  55. Menopause Treatments: What Works, What Doesn’t
  56. Menopause and HRT
  57. Menopause and Mental Health
  58. Menopause, Perimenopause, Hormone Therapy and Other Treatments With Madelyn Butler, MD [Podcast]
  59. Menopause: Diagnosis & Treatment
  60. Menopause: Diagnosis and Management – Information for the Public: Questions To Ask About Menopause [NICE Guideline]
  61. Menopause: Symptoms & Causes
  62. Menopause: Things You Can Do
  63. Menopause: Understanding the Changes and Finding Relief | Dr Susan Davis | The Proof Podcast EP 256
  64. Mood and the Menopause
  65. Mymenoplan.org [My Menoplan, United States]
  66. National Center for Complementary and Integrative Health: Herbs At A Glance
  67. National Center for Complementary and Integrative Health: How Safe Is This Product or Practice?
  68. Navigating Menopause: Expert Insights and Solutions | Dr Susan Davis | The Proof Podcast EP 245
  69. Non-Estrogen Treatments for Menopausal Symptoms
  70. Nonhormone Treatments for Hot Flashes and Night Sweats
  71. Postmenopause
  72. Short-Term and Long-Term Effects of Tibolone In Postmenopausal Women
  73. Testosterone Therapy In Women: Does It Boost Sex Drive?
  74. The 2023 Practitioner’s Toolkit for Managing Menopause
  75. The North American Menopause Society Releases Its 2022 Hormone Therapy Position Statement
  76. The Truth About Menopause Supplements | Dr Sarah Berry
  77. Therapy for the Effects of Menopause
  78. Tibolone As Menopausal Hormone Therapy
  79. Tibolone Brand Name: Livial
  80. Tibolone Brand Name: Livial – About Tibolone
  81. Tibolone Brand Name: Livial – Common Questions About Tibolone
  82. Tibolone Brand Name: Livial – How and When To Take Tibolone
  83. Tibolone Brand Name: Livial – Side Effects
  84. Tibolone Brand Name: Livial – Taking Tibolone With Other Medicines and Herbal Supplements
  85. Tibolone Brand Name: Livial – Who Can and Cannot Take Tibolone
  86. Tibolone Tablets
  87. Tips To Help Manage Menopause Symptoms
  88. Top Tips To Improve Your Mental Wellbeing
  89. Vaginal Dryness
  90. Vaginal Dryness
  91. Vaginal Oestrogen
  92. Video Series-2022: Hormone Therapy: Understanding the Risks and Benefits
  93. Video Series-2023: NAMS 2023 Nonhormone Therapies Position Statement for Bothersome Menopause Symptoms
  94. Video Series-2023: New FDA-Approved Nonhormone Option for the Treatment of Hot Flashes
  95. Videos and Podcasts: Videos – Interviews: A Simple Approach To Menopause: The Menopause Quick Six (www.MQ6.ca)
  96. Webinars: Previous – Management of Menopause In Patients With Obesity
  97. Webinars: Previous – Osteoporosis for Midlife Women and Beyond
  98. What Doctors Wish Patients Knew About Menopause
  99. What Everyone Should Know About Menopause Symptoms
  100. Why Didn’t Anyone Tell Me This? Episode 3: Dr Annice Mukherjee: Your Essential Menopause Toolkit

Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Tibolone Brand Name: Livial – About Tibolone. Page Last Reviewed: 05 January 2023. NHS https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/tibolone/about-tibolone/ Accessed: 05 December 2023
  2. Tibolone Brand Name: Livial – About Tibolone. Page Last Reviewed: 05 January 2023. NHS https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/tibolone/about-tibolone/ Accessed: 05 December 2023
  3. Menopausal Hormone Therapy. 2022. European Menopause and Andropause Society https://emas-online.org/wp-content/uploads/2022/05/Menopausal-hormone-therapy.pdf Accessed: 05 December 2023
  4. HRT: Which HRT? Tibolone. Reviewed November 2021. Publication Date 2021:2. Women’s Health Concern https://www.womens-health-concern.org/wp-content/uploads/2022/12/09-WHC-FACTSHEET-HRT-NOV2022-B.pdf Accessed: 05 December 2023
  5. Tibolone Brand Name: Livial – About Tibolone. Page Last Reviewed: 05 January 2023. NHS https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/tibolone/about-tibolone/ Accessed: 05 December 2023
  6. Tibolone As Menopausal Hormone Therapy: Summary. Content Updated September 2023. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/tibolone-as-menopausal-hormone-therapy Accessed: 05 December 2023
  7. Davis, S. R., Taylor, S., Hemachandra, C., Magraith, K., Ebeling, P. R., Jane, F., and Islam, R. M. The 2023 Practitioner’s Toolkit for Managing Menopause: The 2023 Practitioner’s Toolkit for Managing the Menopause Supporting Notes – Management: MHT Formulations and Options: Tibolone. Published Online: 01 December 2023 https://www.tandfonline.com/doi/full/10.1080/13697137.2023.2258783 Accessed: 05 December 2023
  8. Tibolone Brand Name: Livial: About Tibolone. Page Last Reviewed: 05 January 2023. NHS https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/tibolone/about-tibolone/ Accessed: 05 December 2023
  9. HRT: Which HRT? Tibolone. Reviewed November 2021. Publication Date 2021:2. Women’s Health Concern https://www.womens-health-concern.org/wp-content/uploads/2022/12/09-WHC-FACTSHEET-HRT-NOV2022-B.pdf Accessed: 05 December 2023
  10. Tibolone As Menopausal Hormone Therapy: Summary. Content Updated September 2023. Australasian Menopause Society https://www.menopause.org.au/hp/information-sheets/tibolone-as-menopausal-hormone-therapy Accessed: 05 December 2023
  11. HRT: Which HRT? Tibolone. Reviewed November 2021. Publication Date 2021:2. Women’s Health Concern https://www.womens-health-concern.org/wp-content/uploads/2022/12/09-WHC-FACTSHEET-HRT-NOV2022-B.pdf Accessed: 05 December 2023
  12. Tibolone Brand Name: Livial – About Tibolone: Key Facts. Page Last Reviewed: 05 January 2023. NHS https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/tibolone/about-tibolone/ Accessed: 05 December 2023
Topic Last Updated: 05 December 2023 – Topic Last Reviewed: 05 December 2023

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