“1006 healthy women aged 45 to 58 who were recently menopausal were randomly allocated to receive HRT or placebo. Intervention was stopped after 11 years, but…”.1

Umbrella
What may the Hormone Therapy Danish Study Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Danish Study
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Menopausal Hormone Therapy (MHT)

Participants

Hormone Therapy Danish StudyWho are the participants in the Danish study Effect of Hormone Replacement Therapy on Cardiovascular Events In Recently Postmenopausal Women: Randomised Trial?

In HRT and Cardiovascular Prevention the British Menopause Society (BMS) explain:

“1006 healthy women aged 45 to 58 who were recently menopausal were randomly allocated to receive HRT or placebo. Intervention was stopped after 11 years, but follow-up continued for up to 16 years”.2

What is HRT?

HRT can be an abbreviation for Hormone Replacement Therapy.

Cardiovascular Prevention

What do the BMS note about the Danish study?

The BMS note on 10 October 2012:

“A Danish study reported this week in the British Medical Journal has concluded that after 10 years of follow-up, women receiving HRT early after menopause had a significantly reduced risk of mortality, heart failure, or myocardial infarction, with no apparent increase in risk of cancer, stroke, or blood clot”.3

Conclusion

What is the conclusion of the Danish Study?

In International Menopause Society Comments on BMJ Paper on HRT and Menopause the International Menopause Society (IMS) explain:

“The study authors conclude that “After 10-years of randomised treatment and 16 years of total follow-up, women treated with HRT early after menopause had significantly reduced risk of mortality, heart failure, or MI, without any increase of cancer including breast cancer, VTEs or stroke””.4

What is BMJ?

BMJ can be an abbreviation for British Medical Journal.

What is MI?

MI can be an abbreviation for Myocardial Infarction.

What is VTEs?

VTEs can be an abbreviation for Venous Thromboembolisms.

Health Care Provider

What if I would like to find out if the conclusion of the Danish study is applicable to me?

If you would like to find out if the conclusion of the Danish study is applicable to you, it may be in your best interest to choose to talk to your health care provider about this.

One of the points of consensus about menopausal hormone therapy (MHT) in the Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT – endorsed by seven menopause-related organizations – published online 20 June 2016, is:

  • “The option of MHT is an individual decision in terms of quality of life and health priorities as well as personal risk factors such as age, time since menopause and the risk of VTE, stroke, ischemic heart disease and breast cancer. MHT should not be recommended without a clear indication for its use”.5

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Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. HRT and Cardiovascular Prevention. 10 October 2012. British Menopause Society https://thebms.org.uk/2012/10/hrt-and-cardiovascular-prevention/ Accessed: 02 June 2020
  2. HRT and Cardiovascular Prevention. 10 October 2012. British Menopause Society https://thebms.org.uk/2012/10/hrt-and-cardiovascular-prevention/ Accessed: 02 June 2020
  3. HRT and Cardiovascular Prevention. 10 October 2012. British Menopause Society https://thebms.org.uk/2012/10/hrt-and-cardiovascular-prevention/ Accessed: 02 June 2020
  4. International Menopause Society Comments on BMJ Paper on HRT and Menopause. 09 October 2012:1. International Menopause Society https://www.imsociety.org/manage/images/pdf/9a0ec798a970e1174cee8f5f307d493c.pdf Accessed: 02 June 2020
  5. De Villiers, T. J., Hall, J. E., Pinkerton, J. V., Pérez, S. C., Rees, M., Yang, C. and Pierroz, D. D. Revised Global Consensus Statement on Menopausal Hormone Therapy: Section B: General Principles Governing the Use of MHT. Climacteric, 2016;19:4:314 https://www.imsociety.org/manage/images/pdf/ba6379e868044bec13015ac2b84f2753.pdf Accessed: 02 June 2020
Topic Last Updated: 02 June 2020 – Topic Last Reviewed: 02 June 2020
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